Toxicological Risk Assessment for Beginners

1. Front Matter

   Pages i-xxv

   PDF

2. Introduction

   • José A. Torres, Sol Bobst

   Pages 1-18

3. Hazard Identification

   • Tiffany Bredfeldt, Daniel E. Arrieta

   Pages 19-41

4. Dose-Response Assessment

   • Thomas A. Lewandowski, John Norman

   Pages 43-66

5. Exposure Assessment

   • Thomas Grumbles

   Pages 67-89

6. Risk Characterization for Human Health Risk Assessments

   • Rhian B. Cope

   Pages 91-110

7. Risk Assessment Strategies and Techniques for Combined Exposures

   • Cynthia V. Rider, Jane Ellen Simmons

   Pages 111-134

8. Use of Epidemiology in Risk Assessment

   • Martin D. Barrie, Gregory Nichols

   Pages 135-159

9. Emerging Issues in Risk Assessment

   • Sol Bobst

   Pages 161-169

10. Risk Assessment in the European Union (EU)

    • Robert Roy

    Pages 171-186

11. Brief Survey of Global Approaches for Risk Assessment

    • Silvia Berlanga de Moraes Barros, Sol Bobst

    Pages 187-195

12. Skills Development and Resources for Risk Assessment

    • José A. Torres, Nilsa Rivera-Del Valle

    Pages 197-209

13. Case Studies Chapter

    • Sol Bobst, José A. Torres, Rhian B. Cope

    Pages 211-242

14. Back Matter

    Pages 243-250

    PDF

This book serves as a comprehensive introductory guide to the practical aspects of risk assessment. Chapters include clearly defined objectives and summaries. The book includes: hazard identification, dose-response, exposure assessment, risk characterization, chemical mixtures, epidemiology, emerging issues and global perspectives with accessible language. The book concludes with a set of hypothetical case studies.

Toxicological Risk Assessment for Beginners aims not to create an expert, but rather to provide readers with their first understanding of the risk assessment topic. This book was designed with the student in mind. We simplify a complex process for beginners and balance theory with practical aspects, but remain fluid enough to increase difficulty with case studies. By incorporating an action based, step by step approach to learning the risk assessment process, this book provides its readers with an elementary understanding of how the risk assessment process is initiated, developed and finished, making it a valuable guide for graduate students, post-doctoral fellows and early career scientists in industry.

• Chemical Mixtures
• Cumulative Exposure
• Dose-response
• Exposure Assessment
• Hazard Identification
• Risk Assessment

• Independent Toxicology Consultant, Denton, USA

  José A. Torres

• Nexeo Solutions, Houston, USA

  Sol Bobst

José A. Torres, M.S., Ph.D. Dr. Torres has experience in risk assessment, project management, quality control, quality auditing, and quality assurance as applied to consulting, pharmaceuticals and the medical device industry. His interest in risk assessment drove him to pursue advanced courses and workshops at Harvard School of Public Health for Analyzing Risk, TERA Dose-Response Boot Camp, and PBPK basic modeling. He completed a Bachelor in Biology (Magna Cum Laude) with specialty in Biomedical Sciences from Inter American University of Puerto Rico; a Masters in Environmental Science & Management from Turabo University at Puerto Rico; and a Doctoral degree in Environmental Toxicology, sponsored by NASA, from Texas Southern University, Houston Texas. Sol Bobst, Ph.D., DABT Dr. Bobst has participated in several risk assessment reviews, including a publication in the Regulatory Toxicology and Pharmacology journal. He is a ten year member of the Society of Toxicology, and the past president of the Ethical, Legal, and Social Issues specialty section. He graduated Magna Cum Laude, University Honors with a Bachelor’s Degree in Chemistry from Drake University in Des Moines, IA. His Doctoral degree is from the University of Texas Health Science Center at Houston, Texas, and he holds a board certification from the American Board of Toxicology. He continues to live and work in Houston, Texas.

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