Direct Oral Anticoagulants

1. Front Matter

   Pages i-vi

   PDF

2. The Coagulative Cascade

   • Marina Camera

   Pages 1-8

3. Clinical Indications for Direct Acting Oral Anticoagulants

   • Ahmed AlTurki, Riccardo Proietti

   Pages 9-25

4. Pharmacokinetics and Pharmacodynamics of DOAC

   • Nicola Ferri

   Pages 27-40

5. Drug–Drug Interaction with DOACs

   • Alberto Corsini, Nicola Ferri

   Pages 41-69

6. Direct Oral Anticoagulant Reversal for Management of Bleeding and Emergent Surgery

   • Sanela Music, John Eikelboom, Thao Huynh

   Pages 71-91

7. Risk Stratification For and Use of DOAC Therapies for Stroke Prevention in Patient with Atrial Fibrillation

   • Alfredo Caturano, Raffaele Galiero, Serenella Spiezia, Pia Clara Pafundi

   Pages 93-119

8. Use of DOAC in Patients with Kidney Disease

   • Riccardo Vio, Riccardo Proietti, Lorenzo Calo’

   Pages 121-130

9. Anticoagulation in Elderly Patients with Atrial Fibrillation Authors

   • Andreina Carbone, Roberta Bottino, Antonello D’Andrea, Paolo Golino, Gerardo Nigro, Vincenzo Russo

   Pages 131-147

10. The “Obesity Paradox” and the Use of NOAC

    • Roberta Bottino, Andreina Carbone, Biagio Liccardo, Paolo Golino, Gerardo Nigro, Vincenzo Russo

    Pages 149-178

11. Direct Oral Anticoagulation in Cancer Patients

    • Roberta Bottino, Andreina Carbone, Biagio Liccardo, Antonello D’Andrea, Paolo Golino, Gerardo Nigro et al.

    Pages 179-198

12. DOACs and Dementia in Patients with Atrial Fibrillation

    • Ahmed AlTurki, Hasan AlTurki, Riccardo Proietti, T. Jared Bunch

    Pages 199-209

13. Non-vitamin K Antagonists and Cardiac Implantable Electronic Devices

    • Ahmed AlTurki, Riccardo Proietti, Vidal Essebag

    Pages 211-223

14. Direct Oral Anticoagulants and Atrial Fibrillation Ablation

    • Ahmed AlTurki, Riccardo Proietti, Vidal Essebag

    Pages 225-234

15. DOAC Therapy in Patients Post Left Atrial Appendage Occlusion or Isolation

    • T. Jared Bunch

    Pages 235-245

16. Use of Direct Oral Anticoagulants After Transcatheter Aortic Valve Replacement

    • Andrea Scotti, Mauro Massussi, Antonio Landi, George Besis

    Pages 247-254

17. Use of Direct Oral Anticoagulants After Percutaneous Coronary Intervention

    • Antonio Landi, Mauro Massussi, Andrea Scotti, George Besis

    Pages 255-270

18. Direct Oral Anticoagulants and Left Ventricular Thrombosis: The Evidence for a Good Therapeutic Approach

    • Mauro Massussi, Andrea Scotti, Antonio Landi, George Besis

    Pages 271-280

19. Back Matter

    Pages 281-285

    PDF

This book concisely covers the latest developments in the application of direct oral anticoagulants (DOACs) within cardiovascular medicine. It details the pharmacodynamics and pharmacokinetic mechanisms of DOACs and their application in treating patients with conditions ranging from coronary heart disease through kidney disease and cancer, including their perioperative management. 

Direct Oral Anticoagulants: From Pharmacology to Clinical Practice systematically describes the underlying mechanisms associated with DOACs and their use to treat a range of conditions and is an indispensable resource for all trainee and practicing physicians in a range of disciplines seeking a concise up-to-date resource on the topic.  

• Apixaban
• Dabigatran
• Edoxaban
• Rivaroxaban
• Atrial fibrillation
• Stroke prevention
• DOAC
• Direct Oral Anticoagulants
• Non-Vitamin K Antagonists

• Cardiac Rehabilitation Unit Ospedale, Sacra Famiglia Fatebenefratelli, Erba, Italy

  Riccardo Proietti

• McGill University, Montreal, Canada

  Ahmed AlTurki

• Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padova, Italy

  Nicola Ferri

• Department of Medical Translational Sciences, University of Campania “Luigi Vanvitelli” - Monaldi Hospital, Naples, Italy

  Vincenzo Russo

• Division of Cardiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, USA

  T. Jared Bunch

Dr. Riccardo Proietti MD, PhD, graduated at the Catholic University of Rome in 1997. He then specialized in cardiology at the University of Perugia and achieved a PhD degree in Cardiovascular Science at the University of Padua. He accomplished a fellowship in clinical electrophysiology at McGill University Canada. Since 2010, he is Consultant Cardiologist at Luigi Sacco Hospital of Milan with main activity in cardiac pacing and electrophysiology. He is certified in cardiac pacing by the European Heart Rhythm society and in Clinical Electrophysiology by the Heart Rhythm Society. He is author of articles in national and international peer-reviewed journals and a number of book chapters.


Ahmed AlTurki completed internal medicine residency and a fellowship in cardiology at McGill University in Montreal, Canada and is currently undertaking a fellowship in cardiac electrophysiology at the same institution. His main scientific interests include oral anticoagulation for atrial fibrillation, cardiac implantable electronic devices and catheter ablation of atrial fibrillation. He has authored over peer-reviewed journal articles and several book chapters.



Nicola Ferri is Associate Professor in Pharmacology at the University of Padua. His main scientific interest is focused on drugs affecting lipid metabolism and atherosclerosis. He received several honours, among all the award “Giovani Ricercatori” by Italian Society for the study of atherosclerosis (SISA). He is elected in the organizing committee of the European Lipoprotein Club meeting (from 2017 until 2011) and of SISA Veneto section (from 2018-2022). He is authors of more than 100 peer-review manuscripts.

Vincenzo Russo undertook specialist training in Cardiology at Monaldi Hospital. He earned PhD degree in Pathophysiology of the Cardio-Respiratory System from Second University of Naples in 2013. Since 2010, Dr. Russo serves as Consultant Cardiologist at Monaldi Hospital in Naples and as Honorary Fellow in Cardiovascular Diseases at School of Medicine - University of Campania “Luigi Vanvitelli”. He has published over 100 peer-reviewed manuscripts and is an editor for Cardiology Research and Practice.


T. Jared Bunch completed internal medicine residency and fellowships in cardiovascular diseases and electrophysiology at the Mayo Clinic in Rochester Minnesota. He received the Mayo Brothers Distinguished Fellowship Award for clinical care of patients and the Donald C. Balfour Award for meritorious research. He served as an Assistant Professor of Medicine at the Mayo Clinic from 2003-2007, before joining his current partners at Intermountain Heart Rhythm Specialists. He currently directs heart rhythm research at Intermountain Medical Center and is the medical director for heart rhythm services of Intermountain Healthcare. He is involved in multiple national and international trials involving cardiac rhythm management. He has published over 100 manuscripts and 10 book chapters. He is the Editor-in-Chief of Heart Rhythm Case Reports and a section editor for Heart Rhythm. 

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