Glial-Neuronal Signaling in Neuroendocrine Systems

1. Front Matter

   Pages i-xii

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2. Glial–Neuronal Interactions in the Control of Hypothalamic Development

   1. Front Matter

      Pages 1-1

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   2. The Role of Microglia in the Developing Hypothalamus

      • Jessica M. Rosin, Deborah M. Kurrasch

      Pages 3-28

3. Glial–Neuronal Interactions in the Control of the Magnocellular Neuroendocrine System

   1. Front Matter

      Pages 29-29

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   2. Functional Consequences of Morphological Plasticity in the Adult Hypothalamo-Neurohypophysial System

      • Daniel L. Voisin, Aude Panatier, Stéphane H. R. Oliet

      Pages 31-61

   3. Fenestrated Capillary and Dynamic Neuro-Glial-Vascular Reorganization of the Adult Neurohypophysis

      • Seiji Miyata

      Pages 63-79

   4. Astrocyte–Magnocellular Neuron Interactions in Hypothalamic Memory

      • Grant R. Gordon, Christopher V. Dayas, Jaideep S. Bains

      Pages 81-103

   5. The Multifaceted Roles of Hypothalamic Astrocytes and Microglial Cells in Neuroendocrine and Autonomic Regulation in Health and Disease

      • Ferdinand Althammer, Javier E. Stern

      Pages 105-123

4. Glial–Neuronal Interactions in the Control of Metabolic Function

   1. Front Matter

      Pages 125-125

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   2. Control of Systemic Metabolism by Astrocytes in the Brain

      • Ophélia Le Thuc, Tim Gruber, Matthias H. Tschöp, Cristina García-Cáceres

      Pages 127-154Open Access

   3. Glia-Neuron Communication: Not a One-Way Street

      • Andy Tran, Jim T. C. Chen, Denise D. Belsham

      Pages 155-180

5. Glial–Neuronal Interactions in the Control of the Stress Response

   1. Front Matter

      Pages 181-181

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   2. Retrograde Signaling Via Dendritic Activation of Glial-Neuronal Circuits

      • Juhee Haam, Zhiying Jiang, Jeffrey G. Tasker

      Pages 183-203

6. Glial–Neuronal Interactions in the Control of Reproductive Function

   1. Front Matter

      Pages 205-205

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   2. Microglia, Hormones, and Behavior

      • Jaclyn M. Schwarz, Margaret M. McCarthy

      Pages 207-228

   3. Hypothalamic Astrocytes and the Role of Neuroprogesterone in Estrogen Positive Feedback

      • Paul Micevych, Margaret Mohr

      Pages 229-251

7. Glial–Neuronal Interactions that Link Brain and Periphery

   1. Front Matter

      Pages 253-253

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   2. Unveiling the Importance of Tanycytes in the Control of the Dialogue Between the Brain and the Periphery

      • Sreekala Nampoothiri, Manon Duquenne, Vincent Prevot

      Pages 255-284

   3. Tanycyte Regulation of Hypophysiotropic TRH Neurons

      • Ronald M. Lechan, Csaba Fekete

      Pages 285-307

8. Correction to: Control of Systemic Metabolism by Astrocytes in the Brain

   • Ophélia Le Thuc, Tim Gruber, Matthias H. Tschöp, Cristina García-Cáceres

   Pages C1-C2Open Access

This volume discusses current research on glial-neuronal interactions in several neuroendocrine systems. Glial-neuronal bidirectional transmission represents one of the fastest-growing areas of investigation in neuroscience today.

Unraveling the interactions and signaling synergy between glial cells and neurons is critical to advancing our understanding of brain function. Consequently, this book summarizes the latest findings on the roles of astrocytes, microglia and tanycytes in the control of synaptic transmission, synaptic plasticity, blood-brain signaling, neuroinflammation and immune signaling. In addition, leading experts in the field discuss how reproductive function, the stress response and energy homeostasis are regulated by glial-neuronal communication.

Given its scope, the book is essential reading for undergraduate and graduate students in the neurosciences, as well as postdoctoral fellows and established researchers who are looking for a comprehensive overview of glial-neuronal crosstalk in neuroendocrine systems.

This is the eleventh volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley), which aims to illustrate the highest standards and highlight the latest technologies in basic and clinical research, and aspires to provide inspiration for further exploration into the exciting field of neuroendocrinology.

Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

• Astrocytes
• Blood-Brain Barrier
• Glia-Neuron Communication
• Hypothalamic Neurons
• Microglia
• Neuroinflammation
• Neuroendocrine System
• Synaptic Plasticity

• Cell and Molecular Biology Department and Tulane Brain Institute, Tulane University, New Orleans, USA

  Jeffrey G. Tasker

• Hotchkiss Brain Institute, University of Calgary, Calgary, Canada

  Jaideep S. Bains

• Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, CIBERobn, Spain

  Julie A. Chowen

Jeffrey Tasker received his B.A. from the University of Colorado in 1981 and his M.S. equivalent and Ph.D. from the University of Bordeaux II in 1986, working with Drs. Dominique Poulain and Dionysia Theodosis. He then joined Dr. F. Edward Dudek’s lab for his postdoctoral research at the UCLA Neuropsychiatric Institute. He joined the faculty of Tulane University in 1991, where he currently holds the positions of Professor of Cell and Molecular Biology and Endowed Chair in Neuroscience. His research focuses on the neural circuit, electrical and molecular mechanisms of neuronal, astroglial, and neuroendocrine control of physiological homeostasis, the stress response, and stress disorders.

Dr. Jaideep Bains is a Professor of Physiology and Pharmacology and a member of the Hotchkiss Brain Institute at the University of Calgary, Canada. He received his Ph.D. from Queen’s University (Canada) in 1997. He established his lab at the University of Calgary in 2001. His researchuses electrophysiology, optogenetics, imaging and behavior to understanding how neurons, astrocytes, and brain circuits are modified by stress.

Julie A. Chowen received her B.S. from Lake Superior State University in 1982 and her Ph.D. in Physiology from the University of Washington in 1990. She joined Dr. Luis Miguel García-Segura’s laboratory at the Cajal Institute for Neuroscience in Madrid for her postdoctoral research. In 1999 she established her laboratory in the Department of Endocrinology at the Hospital Infantil Niño Jesús in Madrid. Her research focuses on the neuroendocrine control of metabolism, early nutritional and hormonal influences on long-term metabolism and the role of astrocytes in mediating metabolic signals.

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