Current Topics in Microbiology and Immunology

Vaccination Strategies Against Highly Variable Pathogens

Editors: Hangartner, Lars, Burton, Dennis R. (Eds.)

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  • Discusses modern vaccine approaches aiming to cope with highly variable pathogens
    Provides the reader with a better understanding of antigen design, immunodominance, analysis of antibody responses and vaccine formulations
    An invaluable source of information for the fight against emerging viruses

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  • ISBN 978-3-030-58004-9
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About this book

Vaccines against antigenically stable pathogens, or pathogens that only exist in a limited number of serotypes, have been very successful in the past and have drastically decreased the incidence and lethality of many diseases. However, when it comes to highly variable pathogens or viruses that exist in multiple serotypes, the traditional methods for vaccine development have reached their limits.
This volume highlights the development of vaccines against such challenging pathogens. Novel approaches for immunogen design, including structure-guided vaccine development and vaccines targeting glycans, as well as adjuvants and animal models used for testing possible vaccine candidates are outlined and discussed in detail. Given its scope, the book will appeal to scientists in the fields of infectious diseases, microbiology and medicine. 

About the authors

​Lars Hangartner, Ph.D.
Lars Hangartner is a molecular biologist and immunologist whose research focuses on the humoral response against variable pathogens, such as influenza A virus and HIV. Moreover, he has performed basic studies on measles virus and lymphocytic choriomeningitis virus. He is currently an associate professor at the Scripps Research Institute in La Jolla, California, and his present research investigates Fc/FcγR interactions as well as epitope mapping of polyclonal antibody response in the context of HIV vaccine development. 
Dennis R. Burton, Ph.D.
Dennis Burton is the Chair and Professor in the Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA and James and Jessie Minor Chair in Immunology. He is the Scientific Director of the IAVI Neutralizing Antibody Center, Director of The Consortium for HIV/AIDS Vaccine Development (CHAVD) at Scripps, and a member of the Ragon Institute of MGH, MIT and Harvard, Boston, USA. His research is focused on infectious disease, in particular the interplay of antibodies and highly mutable viruses, notably HIV. He is interested in the potential of broadly neutralizing antibodies to inform vaccine design.

Table of contents (6 chapters)

Table of contents (6 chapters)

Buy this book

eBook £87.50
price for United Kingdom (gross)
  • ISBN 978-3-030-58004-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase Institutional customers should get in touch with their account manager
Hardcover £109.99
price for United Kingdom (gross)
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Bibliographic Information

Bibliographic Information
Book Title
Vaccination Strategies Against Highly Variable Pathogens
Editors
  • Lars Hangartner
  • Dennis R. Burton
Series Title
Current Topics in Microbiology and Immunology
Series Volume
428
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-58004-9
DOI
10.1007/978-3-030-58004-9
Hardcover ISBN
978-3-030-58003-2
Series ISSN
0070-217X
Edition Number
1
Number of Pages
VII, 180
Number of Illustrations
1 b/w illustrations, 15 illustrations in colour
Topics