Advances in Experimental Medicine and Biology

Necrotizing Soft Tissue Infections

Clinical and Pathogenic Aspects

Editors: Norrby-Teglund, Anna, Svensson, Mattias, Skrede, Steinar (Eds.)

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  • Provides a comprehensive overview on pathogenic mechanisms, diagnostic aspects and treatment of necrotizing soft tissue infections
  • Illustrated by various case reports
  • Discusses the application of systems medicine in necrotizing soft tissue infections
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eBook £95.50
price for United Kingdom (gross)
  • ISBN 978-3-030-57616-5
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  • ebooks can be used on all reading devices
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Hardcover £119.99
price for United Kingdom (gross)
About this book

This volume aims to enhance the current understanding of clinical features, treatment and pathogenic aspects in necrotizing soft tissue infections. Various representative case studies are discussed to enhance the readers’ understanding of these complex diseases. Necrotizing soft tissue infections are rapidly spreading infections that may cause extensive soft tissue or limb loss, multiorgan failure and are associated with a considerable fatality rate. It is undisputed that rapid diagnosis and prompt intervention is directly related to survival. The initial presentation may be limited to unspecific symptoms such as tenderness, swelling, erythema and pain. Thus, diagnosis and management are challenging due to heterogeneity in clinical presentation, in co-morbidities, in microbiological aetiology, as well as in the pathogenic mechanisms. An international and multidisciplinary consortium, INFECT, has for the last 6 years been pursuing research aimed to advance the understanding of the clinical and pathogenic aspects of these infections. A central part has been to create a comprehensive clinical registry and associated biobank which have also formed the basis for the experimental studies. Using the INFECT patient cohort, as well as an integrated systems biology approach in patients and clinically relevant experimental models,  an advanced insight of diagnostic features, causative microbial agents, treatment strategies, and pathogenic mechanisms (host and bacterial disease traits and their underlying interaction network) has been obtained.

Table of contents (12 chapters)

Table of contents (12 chapters)
  • The INFECT-Project: An International and Multidisciplinary Project on Necrotizing Soft Tissue Infections

    Pages 1-6

    Svensson, Mattias (et al.)

  • Necrotizing Soft Tissue Infections: Case Reports from the Patients Prospective

    Pages 7-20

    Cartledge, Doreen (et al.)

  • Necrotizing Soft Tissue Infections: Case Reports, from the Clinician’s Perspectives

    Pages 21-37

    Nedrebø, Torbjørn (et al.)

  • Necrotizing Soft-Tissue Infections: Clinical Features and Diagnostic Aspects

    Pages 39-52

    Madsen, Martin Bruun (et al.)

  • Microbiological Etiology of Necrotizing Soft Tissue Infections

    Pages 53-71

    Skrede, Steinar (et al.)

Buy this book

eBook £95.50
price for United Kingdom (gross)
  • ISBN 978-3-030-57616-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase Institutional customers should get in touch with their account manager
Hardcover £119.99
price for United Kingdom (gross)
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Bibliographic Information

Bibliographic Information
Book Title
Necrotizing Soft Tissue Infections
Book Subtitle
Clinical and Pathogenic Aspects
Editors
  • Anna Norrby-Teglund
  • Mattias Svensson
  • Steinar Skrede
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1294
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-57616-5
DOI
10.1007/978-3-030-57616-5
Hardcover ISBN
978-3-030-57615-8
Series ISSN
0065-2598
Edition Number
1
Number of Pages
VIII, 207
Number of Illustrations
13 b/w illustrations, 47 illustrations in colour
Topics