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Protein Kinase-mediated Decisions Between Life and Death

  • Discusses the hot topic subjects related to protein phosphorylation and protein kinases that are not covered in the existing books
  • Uniquely concentrated on the issues related to human living and the critical features that should be considered during clinical translation and application
  • Presents the recent findings about the dual effects of the protein kinases in critical subjects

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1275)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-viii
  2. Aging and Protein Kinases

    • Ayse Basak Engin, Atilla Engin
    Pages 35-69
  3. The Connection Between Cell Fate and Telomere

    • Ayse Basak Engin, Atilla Engin
    Pages 71-100
  4. Dark-Side of Exosomes

    • Atilla Engin
    Pages 101-131
  5. Signal Transduction in Immune Cells and Protein Kinases

    • Monica Neagu, Carolina Constantin
    Pages 133-149Open Access
  6. Role of Protein Kinase C in Immune Cell Activation and Its Implication Chemical-Induced Immunotoxicity

    • Emanuela Corsini, Erica Buoso, Valentina Galbiati, Marco Racchi
    Pages 151-163
  7. Bile Acid Toxicity and Protein Kinases

    • Atilla Engin
    Pages 229-258
  8. Alzheimer’s Disease and Protein Kinases

    • Ayse Basak Engin, Atilla Engin
    Pages 285-321
  9. Bacterial Protein Kinases

    • Evren Doruk Engin
    Pages 323-338
  10. Protein Kinases in Hematological Disorders

    • Mufide Okay, Ibrahim C. Haznedaroglu
    Pages 383-393
  11. Metabolic Stress and Immunity: Nutrient-Sensing Kinases and Tryptophan Metabolism

    • Johanna M. Gostner, Dietmar Fuchs, Katharina Kurz
    Pages 395-405
  12. Correction to: Signal Transduction in Immune Cells and Protein Kinases

    • Monica Neagu, Carolina Constantin
    Pages C1-C1
  13. Back Matter

    Pages 407-415

About this book

Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context.  Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information.

Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Editors and Affiliations

  • Department of Toxicology, Faculty of Pharmacy, Gazi University, Ankara, Turkey

    Ayse Basak Engin

  • Department of General Surgery, Faculty of Medicine, Gazi University, Ankara, Turkey

    Atilla Engin

About the editors

Ayse Basak ENGIN, M.Sc., Ph.D., Ph.D., E.R.T., ATS received her undergraduate degree in Pharmacy and MSc. degree in Toxicology from Hacettepe University. She completed her PhD studies in Toxicology and Immunology at Gazi University. She is currently working at the same University, Faculty of Pharmacy, Department of Toxicology as a full professor. Dr. Engin authored/co-authored several publications, book chapters and edited 4 books. She has been awarded Blair-Curtius-Pfleiderer-Wachter Award for Pteridine Research and Turkish Pharmaceutical Science Academy Young Scientist Award. Her work is mainly focused on pteridines and tryptophan metabolism-neurotoxicology, immunotoxicology and nanosafety-nanomedicine.

Atilla ENGIN M.D., Ph.D. was formerly Professor of General Surgery at Gazi University. He is currently professor emeritus. He earned Ph.D. in Biochemistry from Hacettepe University. His doctoral research led to discovery of the relationship betweenthe cancer growth-rate and tissue glutathione concentrations, and these works have been cited for several times and won the “Science Award in Surgery”. He is a pioneer scientist in experimental surgery. His nationally and internationally funded research projects’ findings, book chapters and edited 7 books have been cited in numerous international publications. While some of these outcomes received national and international awards, some of them were included into scientific databases. His work is mainly focused on oxidative stress, endocrine and metabolic pathways.

Bibliographic Information

  • Book Title: Protein Kinase-mediated Decisions Between Life and Death

  • Editors: Ayse Basak Engin, Atilla Engin

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-030-49844-3

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-49843-6Published: 05 February 2021

  • Softcover ISBN: 978-3-030-49846-7Published: 05 February 2022

  • eBook ISBN: 978-3-030-49844-3Published: 04 February 2021

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VIII, 415

  • Number of Illustrations: 7 b/w illustrations, 23 illustrations in colour

  • Topics: Pharmacology/Toxicology

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access