Antimicrobials in Livestock 1: Regulation, Science, Practice

1. Front Matter

   Pages i-xxix

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2. Introduction

   • Lucie Pokludová

   Pages 1-4

3. Status Quo in International Context

   • Gérard Moulin, Lucie Pokludová

   Pages 5-18

4. EU Policies and Regulatory Surroundings

   • Lucie Pokludová, Jiří Bureš

   Pages 19-41

5. Use of Antimicrobials in Practice (Targeted on Cattle, Pigs, Poultry, Horses)

   • Nancy De Briyne, Despoina Iatridou, Wannes Vanderhaeghen, Kristine Ignate

   Pages 43-79

6. Considerations Reflecting Possible Risks from Use of Antimicrobials

   • Lucie Pokludová, Leona Nepejchalová

   Pages 81-124

7. Prevention Is Better Than Cure

   • Lucie Pokludová

   Pages 125-165

8. Mass Medications: Prophylaxis and Metaphylaxis, Cascade and Off-label Use, Treatment Guidelines and Antimicrobial Stewardship

   • Keith Edward Baptiste, Lucie Pokludová

   Pages 167-193

9. Laboratory Investigations and Result Interpretation

   • Kateřina Nedbalcová, Lucie Pokludová

   Pages 195-232

10. Wider Context of Antimicrobial Resistance, Including Molecular Biology Perspective and Implications for Clinical Practice

    • Lucie Pokludová, Hana Prátová

    Pages 233-279

11. Molecular Biology Perspective of Susceptibility and Resistance in Main Target Pathogens in the Respective Species and Antimicrobials of Concern

    • Lucie Pokludová

    Pages 281-359

12. Back Matter

    Pages 361-374

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This first volume in a two-volume work enhances readers’ understanding of antimicrobial resistance mechanisms in selected bacterial species that cause diseases in major food producing animals. It provides an overview of the current legislation and policies seeking to regulate the authorisation, manufacturing, distribution and use of veterinary antimicrobials in practice in a way that helps to contain the spread of antimicrobial resistance. The focus is put on Europe, without neglecting the global context. Moreover, attention is paid to various uses of antimicrobials in livestock, considering both their risks and benefits, from the distant past to the present. 


Growth promotion, prophylaxis, metaphylaxis, diagnostics and treatment are discussed not only with regard to food production and animal health, but also considering the One Health concept, which combines public and animal health with environmental aspects. A summary of various systems for monitoring the use of antimicrobials is provided, as well as an overview of the diseases that European veterinarians most often treat with antimicrobials. In closing, the book addresses the complexity of recent measures that are of key importance for antimicrobial stewardship, e.g. biosecurity, vaccination and other preventive tools including the newest technologies like smart farming. 


The complete two-volume work provides an extensive review of various aspects related to the use of antimicrobials in veterinary medicine, especially considering major food producing species, their most common infectious diseases and causative pathogens, and mainly focusing on the situation in Europe, without ignoring the global context. While Volume I discusses more general aspects of antibiotic use such as regulatory, laboratory and practical issues from different perspectives, Volume II more specifically discusses medical aspects and the use of antimicrobials in cattle, pigs, poultry and horses, as well as pharmacokinetics and pharmacodynamics, two of the most important factors determining the success of treatment. In both volumes, each chapter confronts the reader with open questions to stimulate further discussions and future research on the topics covered.

• Antibiotics
• Farm Animals
• Livestock Production
• Prophylaxis
• Resistance Mechanism

• Institute for State Control of Veterinary Biologicals and Medicines, Brno, Czech Republic

  Lucie Pokludová

Lucie Pokludová had graduated as microbiologist at the Faculty of Science at Masaryk University in Brno, Czech Republic and finished PhD studies in analytical microbiology and computer image analysis. She worked as microbiologist, then residue assessor and current experience is as assessor of efficacy of antimicrobials and AMR at Institute for State Control of Veterinary  Biologicals and Medicines. She represents the Czech Republic on different global and European fora, as e.g. EMA - ESVAC, EU JAMRAI project EARS-vet, AACTING and VETCAST and for more than 10 years has participated the One Health Czech National Action Plan on AMR. As part time job she teaches at Masaryk University in Brno, but also performs regular lectures in European AMR BTSF programme as well as invited lectures on different occasions, enjoying teaching as well as communication and sharing the views with students, veterinarians and further audience bringing her different experiences from practice. She loves her jobs but also her family, being married and having 2 children.

Policies and ethics