Tumor Microenvironment

1. Front Matter

   Pages i-x

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2. IL-1 Signaling in Tumor Microenvironment

   • Weizhou Zhang, Nicholas Borcherding, Ryan Kolb

   Pages 1-23

3. Interleukin-8 in the Tumor Immune Niche: Lessons from Comparative Oncology

   • Jong-Hyuk Kim

   Pages 25-33

4. IL-9 and Th9 Cells in Tumor Immunity

   • Ying He, Lin Dong, Yejin Cao, Yujing Bi, Guangwei Liu

   Pages 35-46

5. IL-17 Signaling in the Tumor Microenvironment

   • R. M. Gorczynski

   Pages 47-58

6. Emerging Roles for Interleukin-18 in the Gastrointestinal Tumor Microenvironment

   • Ka Yee Fung, Paul M. Nguyen, Tracy L. Putoczki

   Pages 59-72

7. IL-21 Signaling in the Tumor Microenvironment

   • Ghita Chabab, Nathalie Bonnefoy, Virginie Lafont

   Pages 73-82

8. ST2 Signaling in the Tumor Microenvironment

   • Chih-Peng Chang, Meng-Hsuan Hu, Yu-Peng Hsiao, Yi-Ching Wang

   Pages 83-93

9. IL-36 Signaling in the Tumor Microenvironment

   • Manoj Chelvanambi, Aliyah M. Weinstein, Walter J. Storkus

   Pages 95-110

10. Back Matter

    Pages 111-115

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Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of interleukins in the tumor microenvironment. Each chapter focuses on the various ways to target the tumor microenvironment by intervention in the interleukin biology, including IL-1, IL-8, IL-21, IL-36 signaling, and more.

Taken alongside its companion volumes, Tumor Microenvironment: The Role of Interleukins – Part A updates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

• Interleukins tumor microenvironment
• IL-12 signaling in the tumor microenvironment
• IL-6 signaling in the tumor microenvironment
• IL-15 signaling in the tumor microenvironment
• IL-24 signaling in the tumor microenvironment
• Signaling tumor microenvironment
• Cell signaling tumor microenvironment
• Interleukins signaling tumor microenvironment

• Department of Radiology, Columbia University Medical Center, New York, NY, USA, Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil

  Alexander Birbrair

​Alexander Birbrair received his Bachelor’s Biomedical degree from Santa Cruz State University in Brazil. He moved to North Carolina, where he finished his PhD in Neuroscience under the mentorship of Osvaldo Delbono. Then, he joined as a posdoc in Stem Cell Biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA).

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