Myosins

1. Front Matter

   Pages i-xi

   PDF

2. Introduction

   • Lynne M. Coluccio

   Pages 1-6

3. Myosin Structures

   • H. Lee Sweeney, Anne Houdusse, Julien Robert-Paganin

   Pages 7-19

4. Cargo Binding by Unconventional Myosins

   • Jianchao Li, Mingjie Zhang

   Pages 21-40

5. The Structure of Acto-Myosin

   • Rasmus R. Schröder

   Pages 41-59

6. Small Molecule Effectors of Myosin Function

   • Dietmar J. Manstein, Matthias Preller

   Pages 61-84

7. Single-Molecule Biophysical Techniques to Study Actomyosin Force Transduction

   • Yasuharu Takagi, Nikolas Hundt, Adam Fineberg

   Pages 85-126

8. High-Speed Atomic Force Microscopy to Study Myosin Motility

   • Noriyuki Kodera, Toshio Ando

   Pages 127-152

9. How Myosin 5 Walks Deduced from Single-Molecule Biophysical Approaches

   • James R. Sellers, Yasuharu Takagi

   Pages 153-181

10. How Actin Tracks Affect Myosin Motors

    • Alicja Santos, Yauhen Shauchuk, Urszula Cichoń, Kevin C. Vavra, Ronald S. Rock

    Pages 183-197

11. Myosins in the Nucleus

    • Ivan V. Maly, Wilma A. Hofmann

    Pages 199-231

12. Myosins in Cytokinesis

    • Thomas D. Pollard

    Pages 233-244

13. Myosins and Disease

    • Lynne M. Coluccio

    Pages 245-316

14. Myosins and Hearing

    • Thomas B. Friedman, Inna A. Belyantseva, Gregory I. Frolenkov

    Pages 317-330

15. The Actomyosin Systems in Apicomplexa

    • Karine Frénal, Aarti Krishnan, Dominique Soldati-Favre

    Pages 331-354

16. Approaches to Identify and Characterise MYO6-Cargo Interactions

    • Thomas O’Loughlin, John Kendrick-Jones, Folma Buss

    Pages 355-380

17. Class IX Myosins: Motorized RhoGAP Signaling Molecules

    • Peter J. Hanley, Veith Vollmer, Martin Bähler

    Pages 381-389

18. Myosin X

    • Hiroshi Tokuo

    Pages 391-403

19. Myosin XVI

    • Beáta Bugyi, András Kengyel

    Pages 405-419

20. Myosin XVIII

    • Manuel H. Taft, Sharissa L. Latham

    Pages 421-438

Myosins are molecular motors that use the energy from ATP hydrolysis to move and exert tension on actin filaments. Although the best-known myosin is myosin II, which powers skeletal muscle contraction, there are at least two dozen classes of myosins, and cells generally express multiple isoforms. Myosins are involved in multiple cellular activities including cell structure, cell migration, intracellular trafficking, and cell-cell contact.
Importantly, loss of function and mutation are associated with diseases including myopathies, hearing impairment, glomerulosclerosis, and cancer. Written by international experts in myosin motors and the approaches used to study them, this book is expected to provide a comprehensive assessment of the current status of our understanding of the structure and molecular mechanism of myosins and their cellular roles.

• migration
• molecular mechanisms
• Molecular Motors
• Actin Filaments
• Cytoskeleton
• ATPases
• Intracellular Transport
• Protein Structure

• Department of Physiology & Biophysics, Boston University School of Medicine, Boston, USA

  Lynne M. Coluccio

Lynne Coluccio, PhD, began her career at Boston University as a Principal Scientist at the Boston Biomedical Research Institute (BBRI) in 1996. After the institute was closed in 2013, she became a Research Associate in the Department of Physiology & Biophysics at the Boston University School of Medicine and has remained since then. While at the BBRI, she played a variety of roles on the committee including as a chair of the Faculty Search Committee and as a member of the Public Relations Committee. Throughout her she career she has mentored dozens of students who have gone into academia, medicine, teaching, and music.

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