Skip to main content
  • Book
  • © 2020

OCT and Imaging in Central Nervous System Diseases

The Eye as a Window to the Brain

  • Broadens understanding of OCT imaging and interpretation in clinical practice
  • Discusses the role of OCT in evaluating disease progression in neurodegenerative disorders
  • Presents translational aspects from animal models to the clinical approach

Buy it now

Buying options

eBook USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

This is a preview of subscription content, log in via an institution to check for access.

Table of contents (25 chapters)

  1. Front Matter

    Pages i-x
  2. Introduction: Retina Imaging—Past and Present

    • Andrzej Grzybowski, Piero Barboni
    Pages 1-5
  3. OCT Technique: Past, Present and Future

    • Tigran Kostanyan, Maria de los Angeles Ramos-Cadena, Gadi Wollstein, Joel S. Schuman
    Pages 7-31
  4. The APOSTEL Recommendations

    • Aykut Aytulun, AndrĂ©s Cruz-Herranz, Lisanne Balk, Alexander U. Brandt, Philipp Albrecht
    Pages 33-39
  5. OCT Angiography: Guidelines for Analysis and Interpretation

    • Enrico Borrelli, Srinivas R. Sadda, Akihito Uji, Giuseppe Querques
    Pages 41-54
  6. Seeing the Brain Through the Eye: What Is Next for Neuroimaging and Neurology Applications

    • Delia Cabrera DeBuc, Gábor Márk Somfai, Gabriella Szatmáry, Edmund Arthur, Jorge A. Jimenez, Carlos Mendoza-Santiesteban et al.
    Pages 55-82
  7. Advances in Retinal Imaging: Retinal Amyloid Imaging

    • Maya Koronyo-Hamaoui, Jonah Doustar, Mia Oviatt, Keith L. Black, Yosef Koronyo
    Pages 83-122
  8. Advances in Retinal Imaging: Real-Time Imaging of Single Neuronal Cell Apoptosis (DARC)

    • Timothy E. Yap, Maja Szymanska, M. Francesca Cordeiro
    Pages 123-138
  9. Retinal Oximetry in Central Nervous System Diseases

    • Anna Bryndis Einarsdottir, Olof Birna Olafsdottir, Sveinn Hakon Hardarson
    Pages 139-145
  10. Optical Coherence Tomography and Optic Nerve Edema

    • Laurel N. Vuong, Thomas R. Hedges III
    Pages 147-167
  11. OCT and Compressive Optic Neuropathy

    • Mário Luiz Ribeiro Monteiro
    Pages 169-194
  12. OCT and Multiple Sclerosis

    • James V. M. Hanson, Carla A. Wicki, Praveena Manogaran, Axel Petzold, Sven Schippling
    Pages 195-233
  13. OCT in Parkinson’s Disease and Related Disorders

    • Ivan Bodis-Wollner, Shahnaz Miri, Sofya Glazman, Eric M. Shrier, Reem Deeb
    Pages 235-262
  14. Optical Coherence Tomography in Alzheimer’s Disease

    • Gianluca Coppola, Vincenzo Parisi, Gianluca Manni, Francesco Pierelli, Alfredo A. Sadun
    Pages 263-288
  15. Other Neurological Disorders: Migraine, Neurosarcoidosis, Schizophrenia, Obstructive Sleep Apnea-Hypopnea Syndrome and Bipolar Disorder

    • Francisco J. Ascaso, Javier Mateo, Laura CabezĂłn, Paula Casas, Andrzej Grzybowski
    Pages 317-342
  16. Hereditary Optic Neuropathies

    • Piero Barboni, Nicole Balducci, Alfredo A. Sadun
    Pages 343-364
  17. Trans Neuronal Retrograde Degeneration to OCT in Central Nervous System Diseases

    • Bernardo F. Sánchez-Dalmau, Anna CamĂłs-Carreras, Ruben Torres-Torres, Johannes Keller, Laura Sanchez-Vela, Elena H. MartĂ­nez-Lapiscina et al.
    Pages 365-374
  18. OCT in Toxic and Nutritional Optic Neuropathies

    • Andrzej Grzybowski, Iwona Obuchowska, Carl Arndt
    Pages 375-400
  19. Animal Models in Neuro Ophthalmology

    • Eduardo M. Normando, M. Francesca Cordeiro
    Pages 401-426

About this book

The second edition of OCT and Imaging in Central Nervous System Diseases offers updated state-of-the-art advances using optical coherence tomography (OCT) regrading neuronal loss within the retina. Detailed information on the OCT imaging and interpretation is provided for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. Covering disorders like multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, intracranial hypertension, Friedreich’s ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia, readers will given insights into effects on the retina and the and optic nerve. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment, and the use of OCT in animal models.

Similar to the first edition, this book is an excellent and richly illustrated reference for diagnosis of many retinaldiseases and monitoring of surgical and medical treatment. OCT allows to study vision from of the retina to the optic tracts. Retinal axons in the retinal nerve fiber layer (RNFL) are non-myelinated until they penetrate the lamina cribrosa. Hence, the RNFL is an ideal structure for visualization of any process of neurodegeneration, neuroprotection, or regeneration. By documenting the ability of OCT to provide key information on CNS diseases, this book illustrates convincingly that the eye is indeed the “window to the brain”.

Editors and Affiliations

  • University of Warmia and Mazury, Olsztyn, Poland

    Andrzej Grzybowski

  • Studio Oculistico d’Azeglio, Bologna, Italy

    Piero Barboni

About the editors

Andrzej Grzybowski, M.D., Ph.D., MBA, is a Professor of Ophthalmology and Chair of Department of Ophthalmology, University of Warmia and Mazury, Olsztyn, Poland; Head of Institute for Research in Ophthalmology, Foundation for Ophthalmology Development, Poznan, Poland.

He is active in international scientific societies including Euretina (Co-opted Board member 2016-2018), Retina Society, AAO (International Fellow; member of the Global ONE Advisory Board and Museum of Vision’s Program Committee), EVER (Board member and chair of cataract section), ESCRS (curator of ESCRS Archive), and ISRS (member of the ISRS International Council), ISBCS, International Council of Ophthalmology (programme coordinator for WCO in 2011-2018), and Cogan Society. He became lifelong member (chair LIV) of the European Academy of Ophthalmology and its Treasurer. He has been active contributor to major ophthalmic conferences worldwide, including AAO (Achievement Award 2017, International Scholar Award 2018), APAO (International Coordinator 2017, Achievement Award 2018), WCO (Programme Coordinator 2010-2018), Euretina, ESCRS, EVER, ISOPT, etc.

He has been active editor, editor in chief and author of more than 450 peer-reviewed international publications (total IF higher than 1000), and over 50 book’s chapters; reviewer for more than 20 journals. He is a member of editorial boards of American Journal of Ophthalmology (IF 4.795), Acta Ophthalmologica (IF 3.157), PLOS One (IF 2.806), Graefe’s Archive for Clinical and Experimental Ophthalmology (IF 2,349), Translational Vision Science & Technology (TVST), (IF 2.221), BMC Ophthalmology (IF 1.586), Clinics in Dermatology (IF 2.253), Journal of Clinical Medicine (IF 5.8); Frontiers in Neurology (IF 3.5), Neuro-Ophthalmology (IF 0.2), Saudi Journal of Ophthalmology, Asia Pacific Academy of Ophthalmology Journal, and editor in chief of Archives of History and Philosophy of Medicine and Historia Ophthalmologica Internationalis.

Piero Barboni, MD, graduated in Medicine and Surgery from the University of Bologna, Italy, in 1986 and went on to complete his Specialization in Ophthalmology at the same university in 1990. After spending almost two decades in private practice, he was appointed Professor of Neuro-ophthalmology in the Department of Neurological Science, Bologna University. Since 2012 Dr. Barboni has been a Consultant Ophthalmologist at the Scientific Institute San Raffaele, University of Milan. His memberships include the Association for Research in Vision and Ophthalmology (ARVO) and the North American Neuro-Ophthalmology Society (NANOS). Dr. Barboni has been sub-investigator in many clinical trials on good clinical practice in multiple sclerosis and is a participant in an international research project on Leber’s hereditary optic neuropathy. He is the author of more than 70 articles in peer-reviewed journals.   


Bibliographic Information

  • Book Title: OCT and Imaging in Central Nervous System Diseases

  • Book Subtitle: The Eye as a Window to the Brain

  • Editors: Andrzej Grzybowski, Piero Barboni

  • DOI: https://doi.org/10.1007/978-3-030-26269-3

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-26268-6Published: 02 January 2020

  • Softcover ISBN: 978-3-030-26271-6Published: 12 March 2021

  • eBook ISBN: 978-3-030-26269-3Published: 01 January 2020

  • Edition Number: 2

  • Number of Pages: X, 561

  • Number of Illustrations: 18 b/w illustrations, 141 illustrations in colour

  • Topics: Ophthalmology, Neurology, Imaging / Radiology

Buy it now

Buying options

eBook USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access