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Fate and Effects of Anticancer Drugs in the Environment

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  • © 2020

Overview

Editors:
  1. Ester Heath

    1. Department of Environmental Sciences, Jožef Stefan Institute, Ljubljana, Slovenia

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  2. Marina Isidori

    1. Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania “L.Vanvitelli”, Caserta, Italy

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  3. Tina Kosjek

    1. Department of Environmental Sciences, Jožef Stefan Institute, Ljubljana, Slovenia

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  4. Metka Filipič

    1. Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, Slovenia

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  • Provides reader insights into the presence of anticancer drug residues in wastewaters and natural aquatic systems
  • Broadens the understanding of effects of anticancer drug residues in the aquatic environment
  • Summarizes the latest studies on presence and effects of these compounds in the environment

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Prioritisation and Predicted Environmental Concentrations

    1. Front Matter

      Pages 1-1
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    2. Approaches for Hazard Assessment Screening, Ranking, and Prioritization of Cytostatic Compounds

      • Adrián Olalla, Jose Luis Rodriguez-Gil, Yolanda Valcárcel
      Pages 3-26

    3. Predicted Environmental Concentrations: A Useful Tool to Evaluate the Presence of Cytostatics in Surface Waters

      • Cristian Gómez-Canela, Mónica S. F. Santos, Helena Franquet-Griell, Arminda Alves, Francesc Ventura, Silvia Lacorte
      Pages 27-54

  3. Environment/Wastewater Treatment

    1. Front Matter

      Pages 55-55
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    2. Hospitals and Pharmacies as Sources of Contamination by Cytostatic Pharmaceuticals: Long-Term Monitoring in the Czech Republic

      • Lucie Blahova, Lenka Dolezalova, Jan Kuta, Sarka Kozakova, Ludek Blaha
      Pages 57-70

    3. Tamoxifen: Occurrence, Fate, Transformation Products, and Non-Conventional Treatment Technologies

      • Carlos Escudero-Oñate, Sara Rodríguez-Mozaz, Laura Ferrando-Climent
      Pages 71-86

    4. Chlorination By-Products of Anticancer Drugs

      • Juan Carlos Guillen, Božo Žonja, Miren López de Alda
      Pages 87-102

    5. Cytostatic Drug Residues in Wastewater Treatment Plants: Sources, Removal Efficiencies and Current Challenges

      • Lida Ioannou-Ttofa, Despo Fatta-Kassinos
      Pages 103-138

    6. Degradation and Elimination of Anticancer Drugs by Water and Wastewater Treatment – Toxicity and Biodegradability Before and After the Treatment

      • Carlos Alexandre Lutterbeck, Ênio Leandro Machado, Klaus Kümmerer
      Pages 139-168

    7. Analytical Methodologies for the Determination of Cytostatic Compounds in Environmental Matrices

      • Sergio Santana-Viera, Sarah Montesdeoca-Esponda, Zoraida Sosa-Ferrera, José Juan Santana-Rodríguez
      Pages 169-195

    8. Removal of Cytostatic Drugs from Water and Wastewater: Progress in the Development of Advanced Treatment Methods

      • Ewa Maria Siedlecka
      Pages 197-219

    9. Occurrence of Cytostatics in Different Water Compartments

      • Paola Verlicchi, Aina Campos Garrigós, Mustafa Al Aukidy
      Pages 221-244

    10. Photodegradation of Cytostatic Drugs in Low-Pressure UV Photoreactor Through Direct and Indirect Pathways

      • Yiqing Zhang, Teik-Thye Lim
      Pages 245-257

    11. Analysis, Occurrence, and Fate of Cyclophosphamide and Ifosfamide in Aqueous Environment

      • Marjeta Česen, Tina Kosjek, Ester Heath
      Pages 259-291

  4. Environment/Wastewater Treatment + Effects

    1. Front Matter

      Pages 293-293
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    2. Fate and Effects of Cytostatic Pharmaceuticals in the Marine Environment

      • Maria João Bebianno, Tainá Garcia da Fonseca
      Pages 295-330

    3. 5-Fluorouracil and Its Prodrug Capecitabine: Occurrence, Fate and Effects in the Environment

      • Milka Ljoncheva, Tina Kosjek, Marina Isidori, Ester Heath
      Pages 331-375

  5. Toxicity (Effects)

    1. Front Matter

      Pages 377-377
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    2. Toxicity of Anticancer Drug Residues in Organisms of the Freshwater Aquatic Chain

      • Chiara Russo, Margherita Lavorgna, Concetta Piscitelli, Marina Isidori
      Pages 379-401
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Keywords

About this book

The book provides current knowledge and research on the presence and effects of anticancer drug residues in the aqueous environment and covers all relevant aspects of the presence of these residues in wastewaters and natural aquatic systems, where numerous analogies between their pharmacokinetics and pharmacodynamics in humans and their effects in the environment can be drawn. This book comprises of 18 chapters and represents the combined work of leading scientists from different research institutions from across the globe. We present the state of the art in the field of anticancer drug residues in the aquatic environment while being cognizant of the many challenges that remain.

Editors and Affiliations

  • Department of Environmental Sciences, Jožef Stefan Institute, Ljubljana, Slovenia

    Ester Heath, Tina Kosjek

  • Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania “L.Vanvitelli”, Caserta, Italy

    Marina Isidori

  • Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, Slovenia

    Metka Filipič

About the editors

Ester Heath, Jožef Stefan Institute, Ljubljana, Slovenia

Bibliographic Information

  • Book Title: Fate and Effects of Anticancer Drugs in the Environment

  • Editors: Ester Heath, Marina Isidori, Tina Kosjek, Metka Filipič

  • DOI: https://doi.org/10.1007/978-3-030-21048-9

  • Publisher: Springer Cham

  • eBook Packages: Earth and Environmental Science, Earth and Environmental Science (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-21047-2Published: 02 January 2020

  • Softcover ISBN: 978-3-030-21050-2Published: 26 August 2021

  • eBook ISBN: 978-3-030-21048-9Published: 01 January 2020

  • Edition Number: 1

  • Number of Pages: XVI, 469

  • Number of Illustrations: 85 b/w illustrations, 33 illustrations in colour

  • Topics: Ecotoxicology, Environmental Health, Environmental Chemistry

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