Molecular Biology of Long Non-coding RNAs

1. Front Matter

   Pages i-vii

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2. Complex Regulation of X-Chromosome Inactivation in Mammals by Long Non-coding RNAs

   • J. Mauro Calabrese

   Pages 1-33

3. Chemical Modifications and Their Role in Long Non-coding RNAs

   • Sindy Zander, Roland Jacob, Tony Gutschner

   Pages 35-63

4. Long Non-coding RNAs and Nuclear Body Formation and Function

   • Alina Naveed, Ellen Fortini, Ruohan Li, Archa H. Fox

   Pages 65-84

5. New Insights into the Molecular Mechanisms of Long Non-coding RNAs in Cancer Biology

   • Ligia I. Torsin, Mihnea P. Dragomir, George A. Calin

   Pages 85-113

6. The Role of Long Non-coding RNAs in Melanoma Genesis and Progression

   • Piyush Joshi, Ranjan J. Perera

   Pages 115-126

7. Long Non-coding RNAs in the Development and Maintenance of Lymphoid Malignancies

   • Melanie Winkle, Agnieszka Dzikiewicz-Krawczyk, Joost Kluiver, Anke van den Berg

   Pages 127-149

8. Long Non-coding RNAs in Vascular Health and Disease

   • Viorel Simion, Stefan Haemmig, Mark W. Feinberg

   Pages 151-179

9. Back Matter

   Pages 181-187

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This second edition shows how long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Advances in the field also include better characterization of human long non-coding RNAs, novel insights into their roles in human development and disease, their diverse mechanisms of action and novel technologies to study them.

• dysregulation
• gene regulation
• lncRNAs
• long non-coding RNAs
• protein-coding
• epigenetic
• OMICs
• Systems Biology

• Case Western Reserve University School of Medicine, Cleveland, USA

  Ahmad M. Khalil

Ahmad Khalil earned his PhD at the University of Florida School of Medicine where he discovered key epigenetic mechanisms that regulate gene expression during mammalian meiosis. Subsequently, he joined the Scripps Research Institute as a postdoctoral fellow (2006-2008) and studied the role of long non-coding RNAs in neurological disorders. In 2008, Dr Khalil moved to Harvard Medical School and the Broad Institute where he played a key role in discovering long intergenic non-coding (linc)RNAs in human cells, and demonstrated that lincRNAs play critical roles in epigenetic regulation of gene expression. In 2010, Dr Khalil joined the faculty at CWRU and his lab continues to study the role of lincRNAs in human health and disease.

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