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Metabotropic Glutamate Receptor Technologies

  • Book
  • © 2021

Overview

Editors:
  1. M Foster Olive

    1. Psychology Department, Arizona State University, Tempe, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Brian T. Burrows

    1. Phoenix Children’s Hospital, Barrow Neurological Institute, Phoenix, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Jonna M. Leyrer-Jackson

    1. Psychology Department, Arizona State University, Tempe, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Neuromethods (NM, volume 164)

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Table of contents (14 protocols)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Technologies for Screening of mGlu Receptor Allosteric Modulators

    • Alice L. Rodriguez, Colleen M. Niswender
    Pages 1-22

  3. Positron Emission Tomography (PET) Imaging of Metabotropic Glutamate Receptor Subtype 2 (mGlu2) Based on a Negative Allosteric Modulator Radioligand

    • Xiaofei Zhang, Zhiwei Xiao, Katsushi Kumata, Tomoteru Yamasaki, Lee Josephson, Ming-Rong Zhang et al.
    Pages 23-37

  4. PET Imaging of Type 5 Metabotropic Glutamate Receptors

    • Stephanie G. Scala, Kelly Smart, Sylvia M. L. Cox, Chawki Benkelfat, Marco Leyton
    Pages 39-56

  5. Electrophysiological and Calcium Imaging Approaches to Study Metabotropic Glutamate Receptors

    • Philippe Coulon
    Pages 57-79

  6. Role of Metabotropic Glutamate Receptors (mGluRs) in the Regulation of Cellular Calcium Signaling: Theory, Protocols, and Data Analysis

    • Vaibhav Dhyani, Sarpras Swain, Rishikesh Kumar Gupta, Abha Saxena, Ranjana Singh, Lopamudra Giri
    Pages 81-115

  7. Optical Approaches for Modulating mGlu Receptor Activity

    • Lauren E. Hood, Jonna M. Leyrer-Jackson, M. Foster Olive
    Pages 117-133

  8. Classic and Modern Approaches to Investigating Interactions Between Dopamine Systems and Metabotropic Glutamate Receptors

    • Kari A. Johnson
    Pages 135-171

  9. Using Western Blotting for the Evaluation of Metabotropic Glutamate Receptors Within the Nervous System: Procedures and Technical Considerations

    • Jonna M. Leyrer-Jackson, Mark D. Namba, Lauren E. Hood, M. Foster Olive
    Pages 173-197

  10. Investigation of mGlu Receptor Cell Surface Trafficking in Acute Brain Slices Using Biotinylation

    • Marek Schwendt
    Pages 199-210

  11. Co-labeling of Neuronal Cells Using DiI Neuronal Filling and Immunohistochemistry to Explore Metabotropic Glutamate Receptor Expression

    • Jonna M. Leyrer-Jackson, Sade Spencer, Cassandra D. Gipson
    Pages 211-225

  12. Fluorescence Immunohistochemistry Techniques for Labeling Metabotropic Glutamate Receptors in the Central Nervous System

    • Ryan S. Pevey, Jonna M. Leyrer-Jackson, Erin Nagy, M. Foster Olive
    Pages 227-242

  13. Multiplex Arrays for Quantifying Relative Levels of Cytokines in Brain Tissue Lysates: Implications for mGlu Receptor-Mediated Alterations

    • Lauren E. Hood, Jonna M. Leyrer-Jackson, Erin K. Nagy, M. Foster Olive
    Pages 243-257

  14. mGlu Receptor Modulation in Murine Models of Stress and Affective Disorders

    • James Maksymetz, Max E. Joffe
    Pages 259-296

  15. Role of Metabotropic Glutamate Receptors in Alcohol-Drinking Behaviors

    • Fawaz Alasmari, Musaad A. Alshammari, Youssef Sari
    Pages 297-311

  16. Back Matter

    Pages 313-314
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Keywords

About this book

This volume highlights various techniques used to study multiple aspects of mGlu receptor function. Chapters in this book cover topics such as modern approaches for the development and screening of allosteric modulators; fluctuations in intracellular calcium induced by mGlu receptor activation; dopamine-glutamate interactions in the central nervous system; methods for assessing mGlu receptor localization; and common techniques for evaluating mGlu modulation in behavior in rodents, including stress and alcohol drinking. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.


Cutting-edge and practical, Metabotropic Glutamate Receptor Technologies provides researchers with a starting point to address important questions regarding mGlu and its importance. Researchers working in the fields of neuroscience and physiology of multiple peripheral systems will find this volume most useful. 


Editors and Affiliations

  • Psychology Department, Arizona State University, Tempe, USA

    M Foster Olive, Jonna M. Leyrer-Jackson

  • Phoenix Children’s Hospital, Barrow Neurological Institute, Phoenix, USA

    Brian T. Burrows

Bibliographic Information

  • Book Title: Metabotropic Glutamate Receptor Technologies

  • Editors: M Foster Olive, Brian T. Burrows, Jonna M. Leyrer-Jackson

  • Series Title: Neuromethods

  • DOI: https://doi.org/10.1007/978-1-0716-1107-4

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2021

  • Hardcover ISBN: 978-1-0716-1106-7Published: 12 February 2021

  • Softcover ISBN: 978-1-0716-1109-8Published: 12 February 2022

  • eBook ISBN: 978-1-0716-1107-4Published: 11 February 2021

  • Series ISSN: 0893-2336

  • Series E-ISSN: 1940-6045

  • Edition Number: 1

  • Number of Pages: XII, 314

  • Number of Illustrations: 11 b/w illustrations, 60 illustrations in colour

  • Topics: Neurosciences

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