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Supramolecules in Drug Discovery and Drug Delivery

Methods and Protocols

  • Book
  • © 2021

Overview

Editors:
  1. Thomas Mavromoustakos

    1. Department of Chemistry, National and Kapodistrian University of Athens, Zografou, Greece

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  2. Andreas G. Tzakos

    1. Department of Chemistry Section of Organic Chemistry and Biochemistry, University of Ioannina, Ioannina, Greece

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    You can also search for this editor in PubMed   Google Scholar

  3. Serdar Durdagi

    1. Computational Biology and Molecular Simulations Laboratory Department of Biophysics, School of Medicine, Bahcesehir University, Istanbul, Turkey

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    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge techniques
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2207)

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Table of contents (23 protocols)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Application of Neutralization and Freeze-Drying Technique for the Preparation of the Beneficial in Drug Delivery 2-Hydroxypropyl-β-Cyclodextrin Complexes with Bioactive Molecules

    • Eirini Christodoulou, Dimitrios Ntountaniotis, Georgios Leonis, Thomas Mavromoustakos, Georgia Valsami
    Pages 1-11

  3. Functionalized Carbon Nanohorns as Drug Delivery Platforms

    • Anastasios Stergiou, Nikos Tagmatarchis
    Pages 13-24

  4. Ultrasonics-Assisted Effective Isolation and Characterization of Exosomes from Whole Organs

    • Burak Derkus, Emel Emregul
    Pages 25-34

  5. Aggregate Determination by Permeation Technique

    • Phennapha Saokham, Thorsteinn Loftsson
    Pages 35-43

  6. Study of Candesartan Cilexetil: 2-Hydroxypropyl-β-Cyclodextrin Interactions : A Computational Approach Using Steered Molecular Dynamics Simulations

    • Sofia Kiriakidi, Thomas Mavromoustakos
    Pages 45-70

  7. Drug Delivery : Hydrophobic Drug  Encapsulation into Amphiphilic Block Copolymer  Micelles

    • Angeliki Chroni, Varvara Chrysostomou, Athanasios Skandalis, Stergios Pispas
    Pages 71-83

  8. Multisensitive Polymeric Nanocontainers as Drug Delivery Systems: Biological Evaluation

    • Maria Theodosiou, Theodora Koutsikou, Eleni K. Efthimiadou
    Pages 85-97

  9. Drug Incorporation in the Drug Delivery System of Micelles

    • Evangelia Soumelidou, Simona Golič Grdadolnik, Thomas Mavromoustakos
    Pages 99-108

  10. Molecular Dynamics Protocols for the Study of Cyclodextrin Drug Delivery Systems

    • Georgios Leonis, Dimitrios Ntountaniotis, Eirini Christodoulou, Thomas Mavromoustakos
    Pages 109-125

  11. Drug Delivery Through Multifunctional Polypeptidic Hydrogels

    • Hermis Iatrou, Panagiota G. Fragouli, Dimitra Stavroulaki, Barbara Athanasiou
    Pages 127-137

  12. Polymersomes from Hybrids -Polypeptides for Drug Delivery Applications

    • Hermis Iatrou, Panagiota G. Fragouli, Dimitris Skourtis, Ioanna Stavropoulou
    Pages 139-150

  13. Drug Delivery Systems Based on Modified Polysaccharides: Synthesis and Characterization

    • Aikaterini-Foteini Metaxa, Eleni Vrontaki, Eleni K. Efthimiadou, Thomas Mavromoustakos
    Pages 151-161

  14. Differential Scanning Calorimetry (DSC) on Sartan/Cyclodextrin Delivery Formulations

    • Nikolaos Naziris, Maria Chountoulesi, Dimitrios Ntountaniotis, Thomas Mavromoustakos, Costas Demetzos
    Pages 163-174

  15. Encapsulation of Small Drugs in a Supramolecule Enhances Solubility , Stability, and Therapeutic Efficacy Against Glioblastoma Multiforme

    • Antonis D. Tsiailanis, Alexander Renziehausen, Serdar Karakurt, Tim Crook, Nelofer Syed, Andreas G. Tzakos
    Pages 175-186

  16. Unveiling the Thermodynamic Aspects of Drug-Cyclodextrin Interactions Through Isothermal Titration Calorimetry

    • Maria V. Chatziathanasiadou, Thomas Mavromoustakos, Andreas G. Tzakos
    Pages 187-198

  17. Antitumor Efficacy of Ceranib-2 with Nano-Formulation of PEG and Rosin Esters

    • Ali Ben Taleb, Selcan Karakuş, Ezgi Tan, Merve Ilgar, Özlem Kutlu, Devrim Gözüaçık et al.
    Pages 199-220

  18. Association of the Thermodynamics with the Functionality of Thermoresponsive Chimeric Nanosystems

    • Nikolaos Naziris, Athanasios Skandalis, Thomas Mavromoustakos, Stergios Pispas, Costas Demetzos
    Pages 221-233

  19. 2D DOSY NMR: A Valuable Tool to Confirm the Complexation in Drug Delivery Systems

    • Christos M. Chatzigiannis, Sofia Kiriakidi, Andreas G. Tzakos, Thomas Mavromoustakos
    Pages 235-246

  20. Drug-Encapsulated Cyclodextrin Nanosponges

    • Maria Tannous, Fabrizio Caldera, Gjylije Hoti, Umberto Dianzani, Roberta Cavalli, Francesco Trotta
    Pages 247-283
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Keywords

About this book

This detailed book aims to provide readers with critical information to accomplish the synthesis of nanosystems for the purpose of supramolecular entities complexing with drugs, targeted drug delivery system characterization, as well as the study of the physical-chemical interactions that govern the stability and properties of these systems. Beginning with a collection of chapters on drug delivery platforms such as cyclodextrins, micelles, liposomes, polymeric, nanotubes, and more, the volume continues with coverage of the study of nanotechnology systems using different biophysical techniques such as DSC, ITC, solid and liquid NMR spectroscopy, and electrochemistry. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and practical, Supramolecules in Drug Discovery and Drug Delivery: Methods and Protocols serves as an ideal guide for researchers working toward drug delivery mechanisms that can tailor their physical chemical properties and enhance their efficacy, while retaining their structures intact.

Editors and Affiliations

  • Department of Chemistry, National and Kapodistrian University of Athens, Zografou, Greece

    Thomas Mavromoustakos

  • Department of Chemistry Section of Organic Chemistry and Biochemistry, University of Ioannina, Ioannina, Greece

    Andreas G. Tzakos

  • Computational Biology and Molecular Simulations Laboratory Department of Biophysics, School of Medicine, Bahcesehir University, Istanbul, Turkey

    Serdar Durdagi

Bibliographic Information

  • Book Title: Supramolecules in Drug Discovery and Drug Delivery

  • Book Subtitle: Methods and Protocols

  • Editors: Thomas Mavromoustakos, Andreas G. Tzakos, Serdar Durdagi

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-0920-0

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2021

  • Hardcover ISBN: 978-1-0716-0919-4Published: 29 October 2020

  • Softcover ISBN: 978-1-0716-0922-4Published: 29 October 2021

  • eBook ISBN: 978-1-0716-0920-0Published: 28 October 2020

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XI, 344

  • Number of Illustrations: 35 b/w illustrations, 85 illustrations in colour

  • Topics: Biotechnology, Pharmacology/Toxicology, Materials Science, general

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