Overview
- Broadens readers’ understanding of the clinical importance of the choroid plexus as the main source of cerebrospinal fluid
- Shares insights into drug development strategies targeting the blood / cerebrospinal fluid barrier using choroid plexus epithelial cells
- Emphasizes the correlation between the production and composition of CSF and the maintenance of normal brain function
Part of the book series: Physiology in Health and Disease (PIHD)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (12 chapters)
-
Front Matter
Keywords
About this book
This book highlights the importance of the choroid plexus, which forms the blood-cerebrospinal fluid barrier and is the site of the major production of the cerebrospinal fluid (CSF). The authors show that this barrier is crucial for maintaining important compositional differences between the blood plasma and the CSF. The choroid plexus epithelial cells also prevent the spread of infectious agents and other blood-borne entities to the brain tissue.
Chapter topics range from the production of CSF by electrolyte regulation in the choroid plexus, to details on the selectively transporting nature of this barrier. Further, the authors elaborate on the important roles of CSF in sustaining brain health by providing hydration, solutes, and nutrients to the brain tissue. Readers will also learn how CSF circulates signaling molecules within the compartments of the brain and removes waste products from the brain tissue. Elucidating the regulation of these processes in thechoroid plexus is not only important for the readers’ understanding of normal brain development and function, but is also crucial for resolving a variety of cerebral challenges that lead to brain edema, as well as developing treatments for diseases. The book discusses disease models like hydrocephalus, sleep disorders, and age-related dementia.
Its comprehensive coverage makes this volume a valuable resource for researchers in cell and neurophysiology, as well as graduate students of the neurosciences.
Editors and Affiliations
About the editors
Jeppe Praetorius
Department of Biomedicine
Aarhus University
Aarhus
Denmark
Department of Biology
Indiana University – Purdue University Indianapolis
IndianapolisIndiana
USA
Helle Damkier
Department of Biomedicine
Aarhus University
Aarhus
Denmark
Bibliographic Information
Book Title: Role of the Choroid Plexus in Health and Disease
Editors: Jeppe Praetorius, Bonnie Blazer-Yost, Helle Damkier
Series Title: Physiology in Health and Disease
DOI: https://doi.org/10.1007/978-1-0716-0536-3
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The American Physiological Society 2020
Hardcover ISBN: 978-1-0716-0535-6Published: 18 April 2020
Softcover ISBN: 978-1-0716-0538-7Published: 18 April 2021
eBook ISBN: 978-1-0716-0536-3Published: 17 April 2020
Series ISSN: 2625-252X
Series E-ISSN: 2625-2538
Edition Number: 1
Number of Pages: VI, 287
Number of Illustrations: 19 b/w illustrations, 46 illustrations in colour
Topics: Human Physiology, Neurosciences, Neurobiology, Pharmacology/Toxicology, Hematology, Neurology