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  • © 2021

Models and Techniques in Stroke Biology

  • Presents animal models mimicking human stroke to provide insights into the underlying pathophysiology

  • Discusses various rodent stroke models, including their strengths and limitations

  • Summarizes the challenges and advances in the treatment and prevention of ischemic stroke

  • Reviews neuroprotective agents to treat and prevent ischemic stroke

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-vii
  2. Rodent Stroke Model Guidelines: An Update

    • Amit Kumar Tripathi, Ravi Shankar Singh, Awakash Soni, Rajavashisth Tripathi, Ranjana Patnaik
    Pages 1-39
  3. Bilateral Common Carotid Artery Occlusion: Stroke Model

    • Chandra Kant Singh Tekam, Saksha Shinde, Ranjana Patnaik, Sanjeev Kumar Mahto
    Pages 41-56
  4. A Non-human Primate Model for Cerebral Stroke

    • Jovel Varghese Jose
    Pages 65-73
  5. Laser Doppler Flowmetry Recording for Rodent Stroke Model Confirmation

    • Sandeep Singh, Geetika Garg, Avnish Kumar Verma, Abhishek Kumar Singh
    Pages 75-83
  6. Laser Speckle Imaging for Cerebral Ischemia and Reperfusion Injury

    • Vijay Kumar, Himanshu Bansal, Rachna Mehta
    Pages 85-95
  7. Cerebrovascular Imaging in a Rodent Stroke Model

    • Saroj Kumar Amar, Uttpal Anand, Ankit Verma
    Pages 97-105
  8. Photothrombotic Stroke Model

    • Ankit Verma, Naveen Kumar Singhal, Uttpal Anand
    Pages 107-115

About this book

This book summarizes various tools and techniques used to provide insights into the cellular and molecular pathophysiology of stroke. It also presents rodent animal models to help shed light on the pathophysiology of ischemic stroke.

Presenting the latest information on the different types of stroke, including embolic, filament, photothrombotic, and bilateral common carotid artery, the book also describes techniques that are used for confirmation of stroke surgery, such as laser speckle imaging (LSI) and laser Doppler flowmetry (LDF), and discusses the non-human primates that are used in stroke surgery, cerebral venous sinuous thrombosis, and neurobehavioral assessment. Lastly, it analyzes various neuroprotective agents to treat and prevent ischemic stroke, and examines the challenges and advances in treating and preventing acute ischemic stroke.


Editors and Affiliations

  • School of Biomedical Engineering, Indian Institute of Technology BHU, Varanasi, India

    Amit Kumar Tripathi

  • Amity Institute of Neuropsychology and Neurosciences, Amity University, Noida, India

    Abhishek Kumar Singh

About the editors

Dr. Amit Kumar Tripathi is a post-doctoral scientist at the School of Biomedical Engineering, Indian Institute of Technology (Banaras Hindu University). He completed his PhD in Endocrinology from CSIR-Central Drug Research Institute, Lucknow, and the Department of Biochemistry, Jamia Hamdard, New Delhi. His doctoral research focused on mechanistic studies to understand neuroprotection and therapeutic targets. He has ten years of research experience in the field of rodent models of various neurosurgical techniques, such as for transient middle cerebral artery occlusion (tMCAO) and cerebral venous sinuses thrombosis (CVS). He has published his research in several peer-reviewed international journals, including the Journal of Biomedical Science and Circulation Research. He is a member of several international scientific societies, including the International Society for Neurochemistry and Society of Toxicology India.

Dr. Abhishek Kumar Singh is an Assistant Professor at Amity Institute of Neuropsychology and Neurosciences, Amity University, Noida, where he has established the state-of-the-art Laboratory for Stem Cell Biology and Neuroscience. He has received his PhD from the CSIR-Indian Institute of Toxicology Research, Lucknow and Department of Biotechnology, Jamia Hamdard, New Delhi, in 2013.

Dr. Singh has published several research articles in respected international journals and book chapters. He is a member of various international scientific societies, including the Indian Academy of Neuroscience and Society of Toxicology India.

Bibliographic Information

  • Book Title: Models and Techniques in Stroke Biology

  • Editors: Amit Kumar Tripathi, Abhishek Kumar Singh

  • DOI: https://doi.org/10.1007/978-981-33-6679-4

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2021

  • Hardcover ISBN: 978-981-33-6678-7Published: 31 March 2021

  • Softcover ISBN: 978-981-33-6681-7Published: 01 April 2022

  • eBook ISBN: 978-981-33-6679-4Published: 30 March 2021

  • Edition Number: 1

  • Number of Pages: VII, 115

  • Number of Illustrations: 2 b/w illustrations, 9 illustrations in colour

  • Topics: Neurosciences, Developmental Biology, Biological Techniques

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access