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Exploration of Host Genetic Factors associated with Malaria

  • Book
  • © 2021

Overview

Authors:
  1. Tabish Qidwai

    1. Faculty of Biotechnology, Institute of Biosciences and Technology, Shri Ramswaroop Memorial University, Barabanki, India

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  • Summarizes host genetic polymorphisms that are associated with malaria susceptibility/resistance

  • Reviews molecular epidemiology and natural selection of alleles in genes associated with malaria

  • Examines the malarial parasite-imposed selective pressure on the human genome

  • Covers the genetic control mechanisms in the human genome against malaria in endemic regions

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xi
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  2. Human Genetics and Infectious Disease

    • Tabish Qidwai
    Pages 1-14

  3. RBC Disorders

    1. Front Matter

      Pages 15-15
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    2. Sickle Cell Gene

      • Tabish Qidwai
      Pages 17-27

    3. Alpha-Thalassemia

      • Tabish Qidwai
      Pages 29-42

    4. Beta-Thalassemia

      • Tabish Qidwai
      Pages 43-53

    5. Duffy Blood Group Locus

      • Tabish Qidwai
      Pages 55-65

  4. Metabolic Enzymes

    1. Front Matter

      Pages 67-67
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    2. Pyruvate Kinase Deficiency

      • Tabish Qidwai
      Pages 69-78

    3. Glucose 6-Phosphate Dehydrogenase Deficiency

      • Tabish Qidwai
      Pages 79-88

  5. Host Immune Response

    1. Front Matter

      Pages 89-89
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    2. TNF Genetic Polymorphisms

      • Tabish Qidwai
      Pages 91-100

    3. iNOS Genetic Polymorphisms

      • Tabish Qidwai
      Pages 101-112

    4. Human Complement Receptor 1 Polymorphisms

      • Tabish Qidwai
      Pages 113-122

    5. Interferon-Alpha Receptor-1 (IFNAR1) Polymorphisms

      • Tabish Qidwai
      Pages 123-132

  6. Cytoadherence

    1. Front Matter

      Pages 133-133
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    2. Intercellular Adhesion Molecule-1 Polymorphisms

      • Tabish Qidwai
      Pages 135-145

    3. Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) Polymorphisms

      • Tabish Qidwai
      Pages 147-157

    4. Vascular Cell Adhesion Molecule-1 (VCAM-1) Polymorphisms

      • Tabish Qidwai
      Pages 159-172
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Keywords

About this book

This book is aimed to cover the role of genetic polymorphisms in human genes related to RBC disorders, metabolic enzymes, immune response, and cytoadherence in the susceptibility/resistance to malaria caused by Plasmodium falciparum. The chapters provide current information on the balancing trait and the significance of such traits in the malaria resistance. The book covers polymorphisms in the genes of the red blood cells-sickle cell anaemia; glucose-6-phosphate dehydrogenase deficiency and thalassemia that confer protection against malaria. In addition, the book explores selection of genetic variations in the human genome as genetic control mechanism against malaria in endemic regions. It also provides a comprehensive overview of the molecular epidemiology and natural selection of alleles in the genes which are associated with malaria, and presents description of the role of human genetic polymorphisms in malaria disease risk and disease outcome.

Authors and Affiliations

  • Faculty of Biotechnology, Institute of Biosciences and Technology, Shri Ramswaroop Memorial University, Barabanki, India

    Tabish Qidwai

About the author

Dr. M. Tabish Qidwai is an Assistant Professor at SRM University, Uttar Pradesh. India. He previously served as an Assistant Professor (contract) in the Department of Biotechnology at Babasaheb Bhimrao Ambedkar University, Lucknow (A Central University)  from 2015-2018; Assistant Professor in the Department of Biotechnology at Raja Balwant Singh College Agra, UP. His research interests are focused on the functional genomics and immunology especially polymorphisms, immunogenetics, and computational biology. He has received with various prestigious awards including the Rashtriya Gaurav Award for remarkable contributions to Science and Technology, Chancellor Gold Medal for first rank in University. He has more than 8 years of teaching experience in genomics, immunology and computational biology. He has published more than 30 research and review articles in peer-reviewed international journals and authored numerous book chapters. He is a member of several national and international scientific societies and organizations including the Indian Science Congress Association, Indian Biophysical Society, Society of Biological Chemists India, Member of International Association of Engineers (IAENG), China, and European Federation of Biotechnology.

Bibliographic Information

  • Book Title: Exploration of Host Genetic Factors associated with Malaria

  • Authors: Tabish Qidwai

  • DOI: https://doi.org/10.1007/978-981-33-4761-8

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2021

  • Hardcover ISBN: 978-981-33-4760-1Published: 09 March 2021

  • Softcover ISBN: 978-981-33-4763-2Published: 10 March 2022

  • eBook ISBN: 978-981-33-4761-8Published: 08 March 2021

  • Edition Number: 1

  • Number of Pages: XI, 172

  • Number of Illustrations: 31 b/w illustrations, 48 illustrations in colour

  • Topics: Human Genetics, Infectious Diseases, Parasitology, Immunology

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