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Histone Mutations and Cancer

  • Book
  • © 2021

Overview

Editors:
  1. Dong Fang

    1. Institute of Life Sciences, Zhejiang University, Hangzhou, China

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    You can also search for this editor in PubMed   Google Scholar

  2. Junhong Han

    1. State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides an overall picture of histone H3 mutations in various tumors
  • Offers a state-of-the-art summary of advances made over the past 10 years in the emerging area of histone mutation
  • Sheds new light on accurate diagnosis and treatment

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1283)

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-vii
    Download chapter PDF

  2. Overview of Histone Modification

    • Yanjun Zhang, Zhongxing Sun, Junqi Jia, Tianjiao Du, Nachuan Zhang, Yin Tang et al.
    Pages 1-16

  3. The Histone H3 Family and Its Deposition Pathways

    • Dominique Ray-Gallet, Geneviève Almouzni
    Pages 17-42

  4. Histone H3K27M Mutation in Brain Tumors

    • Ahmed H. K. El-Hashash
    Pages 43-52

  5. Histone Mutations and Bone Cancers

    • Earnest L. Taylor, Jennifer J. Westendorf
    Pages 53-62

  6. Histone H3G34 Mutation in Brain and Bone Tumors

    • Lei Qiu, Junhong Han
    Pages 63-71

  7. Epigenetic-Targeted Treatments for H3K27M-Mutant Midline Gliomas

    • Victor M. Lu, David J. Daniels
    Pages 73-84

  8. Histone Lysine-to-Methionine Mutation as Anticancer Drug Target

    • Jianhong Yang, Qiang Qiu, Lijuan Chen
    Pages 85-96
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Keywords

About this book

This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant cell tumors of bone. Given the high incidence and tumorigenesis effects of histone H3 mutations, they are also referred to as oncohistones.


This book highlights the advances made in the area over the past 10 years, and offers a state-of-the-art summary of epigenetic alternation, gene expression, protein structure, drug discovery, immunotherapy, and mouse modeling of histone H3 mutations in various tumors. Chiefly intended to provide researchers and graduate students with an overall picture of these mutations, it will also be of interest to researchers in basic oncology, clinical oncology, and epigenetics, as well as academics and clinical oncology practitioners.

Editors and Affiliations

  • Institute of Life Sciences, Zhejiang University, Hangzhou, China

    Dong Fang

  • State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China

    Junhong Han

About the editors

Dr. Dong Fang received his Ph.D. from Tsinghua University, China in 2012. After that, he worked for four years at the Mayo Clinic, USA, where he focused on understanding the role of epigenetic regulation of gene expression and on how oncohistones reprogram the epigenetic landscape and gene expression to drive tumorigenesis. In 2016, he joined the Institute for Cancer Genetics, Columbia University Medical Center, New York, USA as an Associate Research Scientist, and continued his research on oncohistones. He joined Zhejiang University in 2018, and has since established his own laboratory at its Life Sciences Institute, focusing on histone mutations and epigenetic inheritance.


Junhong Han, Ph.D. is a Primary Investigator at the State Key Laboratory of Biotherapy, Sichuan University. He is also a Professor at the West China School of Medicine and a member of the Cancer Center at West China Hospital, Sichuan University. His main research interests are in the areas of DNA replication, epigenetic modifications in genome stability, and cancer epigenetics. Currently, Dr. Han is also working to identify and analyze the genes, pathways, and networks involved in cancer chemoresistance, and to understand the transcriptional heterogeneity for pancreatic ductal adenocarcinoma primary tumor with metastasis. Dr. Han received his Ph.D. in Cell Biology from Tokyo Institute of Technology, Japan and completed his post-doctoral training at the Mayo Clinic in Rochester, Minnesota, USA.

Bibliographic Information

  • Book Title: Histone Mutations and Cancer

  • Editors: Dong Fang, Junhong Han

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-981-15-8104-5

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2021

  • Hardcover ISBN: 978-981-15-8103-8Published: 07 November 2020

  • Softcover ISBN: 978-981-15-8106-9Published: 07 November 2021

  • eBook ISBN: 978-981-15-8104-5Published: 06 November 2020

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VII, 96

  • Number of Illustrations: 2 b/w illustrations, 15 illustrations in colour

  • Topics: Cancer Research, Gene Expression, Protein Science

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