Overview
Covers all key areas of research into gangliosides
Presents significant recent findings in the field
Examines the role of tumor-associated gangliosides in detail
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Table of contents (11 chapters)
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Front Matter
Keywords
About this book
This book presents the latest knowledge and the most recent research results in the field of ganglioside biochemistry. The early chapters cover all relevant background on sialic acids and their biosynthesis, on N-glycolylneuraminic acid (Neu5Gc), which cannot be synthesized by humans, and on general aspects of ganglioside research. Ganglioside adsorption, disorders of ganglioside degradation, and the regulation of gangliosides are thoroughly discussed. A major focus of the book is the role of gangliosides in cancer. Here, the discussion encompasses, for example, the biological importance, antigenicity, and immunological actions of tumor-associated gangliosides (TAGs), the significance of different glycolipids and gangliosides as TAGs, and emerging anti-cancer vaccine strategies. The ability of sialic acids and TAGs of tumor cells to escape immunosurveillance and immunoediting also receives detailed attention. The significance of sialic acids in regulation of the complement system is explained, and the closing chapter focuses especially on the role of sialyl T antigen in cancer. The book will be of value for all who are interested in functional glycobiology and glycomic studies.
Authors and Affiliations
About the author
Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, Sungkyunkwan University
Bibliographic Information
Book Title: Ganglioside Biochemistry
Authors: Cheorl-Ho Kim
DOI: https://doi.org/10.1007/978-981-15-5815-3
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2020
Hardcover ISBN: 978-981-15-5814-6Published: 04 July 2020
Softcover ISBN: 978-981-15-5817-7Published: 05 July 2021
eBook ISBN: 978-981-15-5815-3Published: 03 July 2020
Edition Number: 1
Number of Pages: XVI, 214
Number of Illustrations: 9 b/w illustrations, 48 illustrations in colour
Topics: Gene Expression, Cancer Research, Genetics and Genomics, Biochemistry, general, Membrane Biology