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Geriatric Oncology

  • Reference work
  • © 2020

Overview

Editors:
  1. Martine Extermann

    1. Senior Adult Oncology Program, Moffitt Cancer Center, University of South Florida, Tampa, USA

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  • Offers a complete source for clinicians and researchers

  • Includes coverage of research methods and in-patient care

  • Examines geriatric assessment and management

  • Includes supplementary material: sn.pub/extras

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Table of contents (69 entries)

  1. Front Matter

    Pages i-xxxv
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  2. Epidemiology and Public Health

    1. Front Matter

      Pages 1-1
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    2. Population Trends in Aging and Cancer

      • Lars Lund
      Pages 3-10

    3. Integrating Geriatric Oncology in Public Health Planning

      • Jeanne-Marie Bréchot, Philippe-Jean Bousquet, Claudia Ferrari, Jérôme Viguier, Norbert Ifrah
      Pages 11-21

    4. Healthcare Informatics and Technology in Managing the Older Cancer Patient

      • John Shen, Zhuoer Xie, Arash Naeim
      Pages 23-34

  3. Biology of Aging and Cancer

    1. Front Matter

      Pages 35-35
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    2. Role of Cell Cycle Control, Checkpoints, and DNA Repair Mechanisms in Stem Cells and Changes with Aging and Cancerogenesis

      • Andreas Brown, Hartmut Geiger
      Pages 37-53

    3. Cellular Senescence and Tumor Promotion

      • Marco Demaria
      Pages 55-69

    4. Immunosenescence and Cancer Immunotherapy at Old Age: Basics

      • Tamas Fulop, Jacek M. Witkowski, K. Hirokawa, A. Larbi, G. Pawelec
      Pages 71-90

    5. Aging and Cancer Biology

      • Vladimir N. Anisimov
      Pages 91-109

    6. Chronic Mechanistic Target of Rapamycin Inhibition: Preventing Cancer to Delay Aging or Vice Versa?

      • Heather G. Hambright, Vincent Hurez, Tyler J. Curiel
      Pages 111-128

    7. Calpain-Calpastatin System in Lymphoid Neoplasm of the Aged

      • Jacek M. Witkowski, Anna Mikosik, Ewa Bryl, Tamas Fulop
      Pages 129-140

    8. The Biologic Interconnections Between Aging and Lymphoma

      • Claire Falandry, Clémentine Sarkozy, Gilles Salles
      Pages 141-152

    9. Aging of Natural Killer Cells in Acute Myeloid Leukemia

      • Beatriz Sanchez-Correa, Rafael Solana, Raquel Tarazona
      Pages 153-168

    10. Hematopoietic Stem Cell Aging and Malignant Hemopathies

      • Michele Goodhardt, David Garrick, Luan Dang, Adriano Salaroli, Dominique Bron
      Pages 169-181

    11. Mitochondria, Oxidative Stress, Cancer, and Aging

      • Simone Pecorini, Lara Gibellini, Sara De Biasi, Elena Bianchini, Milena Nasi, Andrea Cossarizza et al.
      Pages 183-204

  4. (Patho)physiology of Aging and Cancer

    1. Front Matter

      Pages 205-205
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    2. Normal and Abnormal Aging (General Perspective for the Oncologist)

      • George E. Taffet
      Pages 207-213

    3. Respiratory Organ Aging and Cancer

      • Leah J. Witt, Carolyn J. Presley
      Pages 215-244

    4. Digestive Organ Aging and Cancer

      • Stéphane Gerard, Zara Steinmeyer, Stéphanie Lozano, Marie Garric, Philippe Girard, Loic Mourey et al.
      Pages 245-267
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Keywords

About this book

This book is intended as a comprehensive resource for clinicians and researchers seeking in-depth information on geriatric oncology. The coverage encompasses epidemiology, the biology and (patho)physiology of aging and cancer, geriatric assessment and management, hematologic malignancies, solid tumors, issues in patient care, and research methods.  

Since cancer is a disease of aging and people are living longer, most cancer patients are now aged 70 and older. Yet the more we age, the more diverse we become in terms of our health, biologic fitness, and cancer behavior. Typically, however, general oncology clinical trials address only a selected healthier and younger population of patients. Geriatric oncology is the area of oncology that addresses these issues but while a wealth of knowledge has been accumulated, information is often difficult to retrieve or insufficiently detailed. The SpringerReference program, in which this book is published, offers an ideal format for overcoming these limitations since it combines thorough coverage with access to living editions constantly updated chapter by chapter via a dynamic peer-review process, ensuring that information remains current and pertinent.

Editors and Affiliations

  • Senior Adult Oncology Program, Moffitt Cancer Center, University of South Florida, Tampa, USA

    Martine Extermann

About the editor

Dr. Martine Extermann is Professor of Oncology and Medicine at the University of South Florida. She is the Program Leader of the Senior Adult Oncology Program at the Moffitt Cancer Center. She earned her medical diploma and her medical Ph.D. at the University of Geneva, Switzerland. She has a Swiss Board Certification in Internal Medicine, specialty Oncology-Hematology. She also holds ABIM certifications in Internal Medicine and Medical Oncology. She has worked at Moffitt since 1994 and has been a Faculty Member since 1997. Her research focuses on cancer in the elderly. Her main areas of investigation are comorbidity, comprehensive assessment, and prediction/prevention of treatment toxicity in older cancer patients.


She is Past President of the International Society of Geriatric Oncology (SIOG), of which she is also a founding board member. She served or is serving on several ASCO committees and on the Editorial Board of the Journal of Clinical Oncology. Dr. Extermann was presented at ASCO 2009 with the B.J. Kennedy Award for Scientific Excellence in Geriatric Oncology. In October 2014, the International Society of Geriatric Oncology (SIOG) presented Dr. Extermann with the Paul Calabresi Award. On October 10, 2015, Dr. Extermann was presented with a Lifetime Achievement Award in Geriatric Oncology by the German Society of Geriatrics and German Society of Hematology/Oncology in Basel, Switzerland.

Bibliographic Information

  • Book Title: Geriatric Oncology

  • Editors: Martine Extermann

  • DOI: https://doi.org/10.1007/978-3-319-57415-8

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Reference Module Medicine

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-319-57414-1Published: 30 January 2020

  • eBook ISBN: 978-3-319-57415-8Published: 29 January 2020

  • Edition Number: 1

  • Number of Pages: XXXV, 1150

  • Number of Illustrations: 26 b/w illustrations, 50 illustrations in colour

  • Topics: Oncology, Geriatrics/Gerontology

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