Inflammation, Infection, and Microbiome in Cancers

1. Front Matter

   Pages i-xii

   PDF

2. Microbiome and the Hallmarks of Cancer

   • Rachel M. Bleich, Janelle C. Arthur

   Pages 1-26

3. Microbiome in Human Gastrointestinal Cancers

   • Olabisi Oluwabukola Coker, Jun Yu

   Pages 27-61

4. The Gut Microbiome and Colorectal Cancer

   • Amy I. Yu, Grace Y. Chen

   Pages 63-96

5. The Impacts of Salmonella Infection on Human Cancer

   • Ikuko Kato, Jun Sun

   Pages 97-109

6. Biomarkers of Esophageal Cancers and Precancerous Lesions

   • Manisha Bajpai, Zhongren (David) Zhou

   Pages 111-153

7. Epithelial and Immune Cell Responses to Helicobacter pylori That Shape the Gastric Tumor Microenvironment

   • Meaghan Torvund, Jayati Chakrabarti, Yana Zavros

   Pages 155-197

8. Gut Microbiome and Liver Cancer

   • John C. McVey, Qianfei Zhang, Tim F. Greten, Chi Ma

   Pages 199-255

9. The Microbiome and Urologic Cancers

   • Mithunah Krishnamoorthy, Saman Maleki Vareki, Jeremy P. Burton

   Pages 257-270

10. Role of Infections and Tissue Inflammation in the Pathology of the Fallopian Tube and High-Grade Serous Ovarian Cancer

    • Mirjana Kessler

    Pages 271-312

11. Commensal Microbes and Their Metabolites: Influence on Host Pathways in Health and Cancer

    • Roberto Mendez, Sulagna Banerjee, Santanu Banerjee

    Pages 313-327

12. Diet, Microbiome, Inflammation, and Cancer

    • Xiaotao Zhang, Carrie R. Daniel

    Pages 329-348

13. Autophagy and Cancer: Current Biology and Drug Development

    • Arianne L. Theiss

    Pages 349-376

14. Mitochondrial Regulation of Inflammation in Cancer

    • Joseph Inigo, Jordan Woytash, Rahul Kumar, Dhyan Chandra

    Pages 377-393

15. Modern Germ-Free Study Designs and Emerging Static Housing Technology in a Growing “Human Microbiome” Research Market

    • Alex Rodriguez-Palacios

    Pages 395-429

16. Machine Learning in Identification of Disease-Associated Microbiota

    • Derek Reiman, Ulises Sosa, Yang Dai

    Pages 431-456

17. Mediation Analysis of Microbiome Data and Detection of Causality in Microbiome Studies

    • Yinglin Xia

    Pages 457-509

This book offers a summary and discussion of the advances of inflammation and infection in various cancers. The authors cover the classically known virus infections in cancer, novel roles of other pathogens (e.g. bacteria and fungi), as well as biomarkers for diagnosis and therapy. Further, the chapters highlight the progress of immune therapy, stem cells and the role of the microbiome in the pathophysiology of cancers.

Readers will gain insights into complex microbial communities, that inhabit most external human surfaces and play a key role in health and disease. Perturbations of host-microbe interactions often lead to altered host responses that can promote cancer development. Thus, this book highlights emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy. The focus is on mechanistic concepts that underlie the complex relationships between host and microbes. Approaches that can inhibit infection, suppress chronic inflammation and reverse the dysbiosis are discussed, as a means for restoring the balance between host and microbes.

This comprehensive work will be beneficial to researchers and students interested in infectious diseases, microbiome, and cancer as well as clinicians and general physiologists.

• Cancer pathogens
• Microbiome
• microbe Infection
• Inflammation
• cancer biomarkers

• Jesse Brown VA Medical Center Chicago (537), Chicago, USA

  Jun Sun

Dr. Jun Sun is a tenured Professor of Medicine at the University of Illinois at Chicago (UIC), U.S.A.. She is an elected fellow of American Gastroenterological Association (AGA) and American Physiological Society (APS). She chairs the AGA microbiome section. Her research interests are host-microbiome interactions in inflammation and cancer. Her key achievements include 1) characterization of vitamin D receptor regulation of intestinal barrier and microbiome in inflammation and cancer, 2) identification of dysbiosis and intestinal dysfunction in amyotrophic lateral sclerosis (ALS), 3) characterization of bacteria in regulating intestinal stem cells and leading to cancer, and 4) identification and characterization of the Salmonella protein AvrA in host-bacterial interactions. Dr. Sun has published over 190 scientific articles in peer-reviewed journals, including Gut, Gastroenterolog, Cell Stem Cells, Nature Genetics, JBC, Autophagy, AmericanJournal of Pathology, & American Journal of Physiology-GI.  She is the leading editor of 4 books on microbiome, including a Nature/Spring book entitled “Mechanisms underlying host-microbiome interactions in pathophysiology of human diseases.”  This book has shown a novel theme and multiple disciplinary topics of microbiome research for a broad audience. She is the author of Nature/Spring book “Statistical Analysis of Microbiome Data with R. This timely book addresses the statistical modelling and analysis of microbiome data using cutting-edge R software. She serves on the editorial board of more than 10 peer-reviewed international scientific journals. She services study sections for the NIH, American Cancer Society, and other national and international research foundations. She has been invited to chair meetings on microbiome, be a keynote speaker, and to write reviews, editorials, and comments on microbiome in human diseases published forpeer-reviewed journals. She is actively involved in advocating microbiome research at the international, national, and institutional levels. Her research is supported by the NIH, DOD, VA, and other research awards.

Dr. Sun is a believer of scientific art and artistic science. She enjoys writing her science papers in English and poems in Chinese. She teaches her medical fellows biomedical knowledge and also the way to translate the Chinese poems. In addition to her research papers and books, her poetry collection《让时间停留在这一刻 》“Let time stay still at this moment”, is published in 2018 by the Chinese Literature and History Press (中国文史出版社).

 

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