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5-HT2B Receptors

From Molecular Biology to Clinical Applications

  • Book
  • © 2021

Overview

Editors:
  1. Luc Maroteaux

    1. Inserm, U1270, Institut du Fer a Moulin, Paris, France

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  2. Laurent Monassier

    1. Pharmacology, Strasbourg Medical school, Strasbourg, France

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • An overview of the role that the 5-HT2B receptor plays in human physiology
  • Covers molecular and physiological aspects
  • Serves as a good reference for biological scientists and medical doctors

Part of the book series: The Receptors (REC, volume 35)

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-viii
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  2. Gene Structure, Expression, and 5-HT2B Receptor Signaling

    • Luc Maroteaux
    Pages 1-32

  3. Development and Growth

    1. Front Matter

      Pages 33-33
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    2. Serotonin Function During Embryonic Development: The 5-HT2B Receptor Contribution

      • Michela Ori, Irma Nardi
      Pages 35-51

    3. Stem Cells to Decipher the Physiological Roles of 5-HT2B Receptor Signaling

      • Anne Baudry, Odile Kellermann, Jean-Marie Launay, Mathéa Piétri, Benoit Schneider
      Pages 53-70

    4. The Serotonergic System in Hematopoiesis and Hematopoietic Disorders

      • Francine Côté, Tereza Coman
      Pages 71-85

    5. The 5-HT2B Receptor, the Immune System and Neuroinflammation

      • Anne Roumier, Catherine Béchade
      Pages 87-97

    6. 5-HT2B Receptor on Macrophages: What for?

      • Concha Nieto, Ignacio Rayo, Angel L. Corbí
      Pages 99-130

  4. Peripheral Actions

    1. Front Matter

      Pages 131-131
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    2. Bone and Serotonin Receptor Type 2B

      • Corinne Collet, Amélie E. Coudert
      Pages 133-142

    3. Roles of 5-HT2B Receptor in Pain

      • Wei-Hsin Sun, Yeu-Shiuan Su
      Pages 143-152

    4. 5-HT2B Receptor, the Heart and Blood Vessels

      • Laurent Monassier
      Pages 153-163

    5. 5-HT2B Receptor in Cardiopulmonary Disease

      • J. Caleb Snider, W. David Merryman
      Pages 165-187

    6. Serotonin and Cardiac Valves Degeneration in Dog

      • Jérôme Guyonnet
      Pages 189-211

    7. The Discovery of 5-HT2B Receptor Pharmacology Through the Understanding of Drug-Induced Valvulopathy

      • Alizée Arnoux, Estelle Ayme-Dietrich
      Pages 213-229

    8. Serotonin and Fibrosis

      • Oliver Distler, Michel Neidhart, PrzemysÅ‚aw BÅ‚yszczuk
      Pages 231-246

    9. 5-HT2B Receptors in Liver

      • Lucy Gee, Fiona Oakley
      Pages 247-264

    10. Metabolic Regulation: Insulin Secretion and Action

      • Wonsuk Choi, Joon Ho Moon, Hail Kim
      Pages 265-274

  5. Brain Actions

    1. Front Matter

      Pages 275-275
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    2. Drugs of Abuse Affecting 5-HT2B Receptors

      • Dino Luethi, Matthias E. Liechti
      Pages 277-289
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Keywords

About this book

This contributed volume provides a comprehensive assessment of the roles played by 5-HT2B receptors in humans. These receptors have been shown to play an important role is the cardiac, intestinal, and central nervous systems as well as in bone marrow formation and growth. In this book, expert researchers present their findings on molecular and physiological/pathological aspects of 5-HT2B receptors. The molecular section includes a discussion of the genetics of 5-HT2B receptors and impulse control. The physiological section covers their role in many biological systems including the nervous system, the heart, and the lungs.​

Editors and Affiliations

  • Inserm, U1270, Institut du Fer a Moulin, Paris, France

    Luc Maroteaux

  • Pharmacology, Strasbourg Medical school, Strasbourg, France

    Laurent Monassier

About the editors

Laurent Monassier is Professor of Pharmacology at the Strasbourg's University, Strasbourg, France, where he leads the Laboratory of NeuroCardiovascular Pharmacology and Toxicology (UR 7296). His research group is interested in the pharmacological modulation of the autonomic nervous system in cardiovascular diseases. In particular, he is interested in developing 5-HT2 receptor antagonists to protect cardiac valves lesions and other 5-HT ligands in various diseases affecting the lung, the heart and the central nervous system. He is also developing new compounds dedicated to various metabolic disorders associated with the metabolic syndrome.

 

 

Luc Maroteaux is Research Director at INSERM U1270, Institut du Fer à Moulin, Sorbonne University, Paris, France, and is leading the "Serotonin, microglia, plasticity and pathologies" team. His research is focusing into the control of neuronal plasticity in the central nervous system and its pathological and pharmacological alterations. In particular, the team discovered that the serotonin 5-HT2B receptor acts in the brain by increasing extracellular serotonin concentrations by a neuron control mechanism that produces serotonin, and that this receptor is involved in impulsive and depressive behaviors. They are currently working on an original concept focusing on the inflammatory origin of certain psychiatric illnesses, always focusing on serotonin.

​

Bibliographic Information

  • Book Title: 5-HT2B Receptors

  • Book Subtitle: From Molecular Biology to Clinical Applications

  • Editors: Luc Maroteaux, Laurent Monassier

  • Series Title: The Receptors

  • DOI: https://doi.org/10.1007/978-3-030-55920-5

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-55919-9Published: 13 March 2021

  • Softcover ISBN: 978-3-030-55922-9Published: 14 March 2022

  • eBook ISBN: 978-3-030-55920-5Published: 12 March 2021

  • Series ISSN: 1048-6909

  • Series E-ISSN: 2524-6488

  • Edition Number: 1

  • Number of Pages: VIII, 401

  • Number of Illustrations: 44 b/w illustrations

  • Topics: Neurosciences, Human Physiology

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