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Mechanisms of Gene Regulation: How Science Works

  • Textbook
  • © 2020

Overview

Authors:
  1. Carsten Carlberg

    1. Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland

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  2. Ferdinand Molnár

    1. Department of Biology, Rm 7e.519, Nazarbayev University, Nur-Sultan, Kazakhstan

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    You can also search for this author in PubMed   Google Scholar

  • Includes a high figure to text ratio to improve learning

  • Based of 18 years teaching experience on the topic

  • Provides in a condensed form an overview on the present understanding of the mechanisms of gene regulation

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Genes and Chromatin

    • Carsten Carlberg, Ferdinand Molnár
    Pages 1-17

  3. Basal Transcriptional Machinery

    • Carsten Carlberg, Ferdinand Molnár
    Pages 19-33

  4. Transcription Factors and Signal Transduction

    • Carsten Carlberg, Ferdinand Molnár
    Pages 35-57

  5. A Key Transcription Factor Family: Nuclear Receptors

    • Carsten Carlberg, Ferdinand Molnár
    Pages 59-70

  6. Genome-Wide Principles of Gene Regulation

    • Carsten Carlberg, Ferdinand Molnár
    Pages 71-82

  7. Chromatin Modifiers

    • Carsten Carlberg, Ferdinand Molnár
    Pages 83-98

  8. Epigenetics

    • Carsten Carlberg, Ferdinand Molnár
    Pages 99-113

  9. Chromatin Remodeling and Organization

    • Carsten Carlberg, Ferdinand Molnár
    Pages 115-128

  10. Regulatory Impact of Non-coding RNA

    • Carsten Carlberg, Ferdinand Molnár
    Pages 129-142

  11. Back Matter

    Pages 143-149
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Keywords

About this book

This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.

Authors and Affiliations

  • Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland

    Carsten Carlberg

  • Department of Biology, Rm 7e.519, Nazarbayev University, Nur-Sultan, Kazakhstan

    Ferdinand Molnár

About the authors

Carsten Carlberg graduated 1989 with a PhD in biochemistry at the Free University Berlin (Germany). After positions as postdoc at Roche (Basel, Switzerland), group leader at the University of Geneva (Switzerland) and docent at the University of Düsseldorf (Germany) he is since 2000 full professor of biochemistry at the University of Eastern Finland in Kuopio (Finland). His work focuses on mechanisms of gene regulation by nuclear hormones, in particular on vitamin D. At present Prof. Carlberg focuses projects on epigenome-wide effects of vitamin D on the human immune system.

 

Ferdinand Molnár received his PhD in biochemistry from the University of Kuopio (Kuopio, Finland) in 2006. He did his postdoctoral training in Structural Biology at the IGBMC (Illkirch, France). In 2008 he joined the School of Pharmacy at the University of Eastern Finland (Kuopio, Finland) studying nuclear receptor-ligand, - protein and -DNA interactions. In 2018 he moved to the Nazarbayev University (Nur-Sultan, Kazakhstan) where he holds an Associate Professor position at the Department of Biology. Prof. Molnár interests are integrative structural biology and bioinformatics, eukaryotic transcriptional regulation in health and disease and recombinant protein production.

Bibliographic Information

  • Book Title: Mechanisms of Gene Regulation: How Science Works

  • Authors: Carsten Carlberg, Ferdinand Molnár

  • DOI: https://doi.org/10.1007/978-3-030-52321-3

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Softcover ISBN: 978-3-030-52320-6Published: 30 October 2020

  • eBook ISBN: 978-3-030-52321-3Published: 29 October 2020

  • Edition Number: 1

  • Number of Pages: XVI, 149

  • Number of Illustrations: 1 b/w illustrations, 70 illustrations in colour

  • Topics: Biomedicine, general, Biochemistry, general, Genetics and Genomics

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