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Tumor Microenvironment

Molecular Players – Part B

  • Provides a comprehensive overview of the state-of-the-art research on various molecular players in the tumor microenvironment, including MicroRNAs, estrogen, Caveolin-1, Nitric Oxide, RANK/RANKL signaling, , COX-2 Signaling, Renin–angiotensin system, and more
  • Illustrates in detail how cancer cells are affected by different molecules, such as exosomes, stem cell secreted factors, and therapeutic monoclonal antibodies
  • Describes how molecular components of the tumor microenvironment and cancer progression are intimately linked

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1277)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xiv
  2. MicroRNAs in the Tumor Microenvironment

    • Nitin Patil, Heike Allgayer, Jörg H. Leupold
    Pages 1-31
  3. The Impact of Estrogen in the Tumor Microenvironment

    • Ashwin Somasundaram, Natalie J. Rothenberger, Laura P. Stabile
    Pages 33-52
  4. The Non-Bone-Related Role of RANK/RANKL Signaling in Cancer

    • Peter A. van Dam, Yannick Verhoeven, Xuan B. Trinh
    Pages 53-62
  5. Exosomes: Novel Players of Therapy Resistance in Neuroblastoma

    • Heather Richard, Arya Pokhrel, Srinivas Chava, Anup Pathania, Santharam S. Katta, Kishore B. Challagundla
    Pages 75-85
  6. COX-2 Signaling in the Tumor Microenvironment

    • Yuan Zhang, Sean Tighe, Ying-Ting Zhu
    Pages 87-104
  7. Renin–Angiotensin System in the Tumor Microenvironment

    • Kenta Nakamura, Ryuhei Okuyama, Yutaka Kawakami
    Pages 105-114
  8. Stem Cell-Secreted Factors in the Tumor Microenvironment

    • Gema Jiménez, Julia López de Andrés, Juan Antonio Marchal
    Pages 115-126
  9. Tumor Microenvironment and Nitric Oxide: Concepts and Mechanisms

    • Anastasia Vedenko, Kush Panara, Gabriella Goldstein, Ranjith Ramasamy, Himanshu Arora
    Pages 143-158
  10. Back Matter

    Pages 159-162

About this book

This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including MicroRNAs, estrogen, Caveolin-1, Nitric Oxide, RANK/RANKL signaling, , COX-2 Signaling, Renin–angiotensin system, and more. 

Taken alongside its companion volumes, Tumor Microenvironment: Molecular Players – Part B updates us on what we know about the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Editors and Affiliations

  • Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil

    Alexander Birbrair

About the editor

Alexander Birbrair received his Bachelor’s Biomedical degree from Santa Cruz State University in Brazil. He moved to North Carolina, where he finished his PhD in Neuroscience under the mentorship of Osvaldo Delbono. Then, he joined as a posdoc in Stem Cell Biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA). He is the Editor-in-Chief of Current Tissue Microenvironment Reports, and associate editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.

Bibliographic Information

  • Book Title: Tumor Microenvironment

  • Book Subtitle: Molecular Players – Part B

  • Editors: Alexander Birbrair

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-030-50224-9

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-50223-2Published: 30 October 2020

  • Softcover ISBN: 978-3-030-50226-3Published: 30 October 2021

  • eBook ISBN: 978-3-030-50224-9Published: 29 October 2020

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIV, 162

  • Number of Illustrations: 1 b/w illustrations, 21 illustrations in colour

  • Topics: Cancer Research, Cell Biology, Internal Medicine

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access