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Progress in Inflammation Research

Nrf2 and its Modulation in Inflammation

Editors: Deng, Huai (Ed.)

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  • Provides a comprehensive and up-to-date account of Nrf2 research
  • Brings together mechanistic understanding and phenotypical/clinical knowledge about Nrf2
  • Covers role of Nrf2 in the immune response during inflammation, inflammation-triggered carcinogenesis, neuroinflammation, atherosclerosis, metabolic diseases, and others
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eBook 117,69 €
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  • ISBN 978-3-030-44599-7
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Hardcover 147,69 €
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About this book

Nrf2, a transcription factor that mediates transcriptional responses to oxidative and xenobiotic stresses, plays a central role in cellular protection against internal or external toxins. Defects in Nrf2 and the relevant regulatory pathways are associated with a number of pathologies including inflammation, respiratory diseases, cardiovascular dysfunctions, metabolic syndrome and diabetes, neurodegeneration, and cancer. This book comprehensively reviews the up-to-date discoveries for the roles of Nrf2 in several human diseases in the context of inflammation. In particular, the molecular mechanisms that mediate the functions of Nrf2 and its interacting network in inflammation and pathogenesis are explicated. In addition, the research and therapeutic applications of Nrf2-targeting compounds in different diseases were summarized. This book is expected to be a valuable reference for worldwide researchers conducting both mechanistic and therapeutic studies of Nrf2 and relevant factors.

   

About the authors

Dr. Deng is an assistant professor in the department of biology at the University of Minnesota Duluth. He obtained a bachelor's degree at Wuhan University and a master's degree at the University of Chinese Academy of Sciences. He got a PhD degree at Iowa State University and completed postdoctoral training at the University of Michigan and Howard Hughes Medical Institute.

Table of contents (8 chapters)

Table of contents (8 chapters)
  • Molecular Mechanisms of Nrf2 in Inflammation: Interactions Between Nrf2 and Inflammatory Mediators

    Pages 1-21

    Wang, Rong (et al.)

  • Nrf2 in Immune Responses During Inflammation

    Pages 23-49

    Hohmann, Miriam S. (et al.)

  • Nrf2 and the Nrf2-Interacting Network in Respiratory Inflammation and Diseases

    Pages 51-76

    Carlson, Jennifer (et al.)

  • Nrf2 in the Regulation of Endothelial Cell Homeostasis During Inflammation

    Pages 77-96

    Yamazaki, Hiromi (et al.)

  • The Role of Nrf2 in the Cardiovascular System and Atherosclerosis

    Pages 97-127

    Mathis, Bryan J. (et al.)

Buy this book

eBook 117,69 €
price for France (gross)
  • ISBN 978-3-030-44599-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 147,69 €
price for France (gross)
  • ISBN 978-3-030-44597-3
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Nrf2 and its Modulation in Inflammation
Editors
  • Huai Deng
Series Title
Progress in Inflammation Research
Series Volume
85
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-44599-7
DOI
10.1007/978-3-030-44599-7
Hardcover ISBN
978-3-030-44597-3
Series ISSN
0379-0363
Edition Number
1
Number of Pages
IX, 205
Number of Illustrations
39 b/w illustrations, 12 illustrations in colour
Topics

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