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  • © 2019

Immunoepidemiology

  • First-of-its-kind textbook addressing the emerging field of immunoepidemiology
  • Emphasizes infectious diseases, autoimmunity, and cancer, while providing principles applicable to myriad chronic diseases
  • Includes sections on basic immunologic principles and their application to diseases in human populations
  • Collates clinical and public health perspectives, by experts from Yale University
  • Unprecedented resource for MPH students, epidemiology and immunology PhD students, medical students, and more

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xxvii
  2. INTRODUCTION

    1. Front Matter

      Pages 1-1
    2. Introduction to Immunology, Epidemiology, and Immunoepidemiology

      • Linda M. Niccolai, Nancy H. Ruddle, Peter J. Krause
      Pages 3-17
  3. IMMUNOLOGY BASICS

    1. Front Matter

      Pages 19-19
    2. Organization and Cells of the Immune System

      • Paula B. Kavathas, Peter J. Krause, Nancy H. Ruddle
      Pages 21-38
    3. Innate Immunity: Recognition and Effector Functions

      • Paula B. Kavathas, Peter J. Krause, Nancy H. Ruddle
      Pages 39-53
    4. Adaptive Immunity: Antigen Recognition by T and B Lymphocytes

      • Paula B. Kavathas, Peter J. Krause, Nancy H. Ruddle
      Pages 55-74
    5. Adaptive Immunity: Effector Functions, Regulation, and Vaccination

      • Paula B. Kavathas, Peter J. Krause, Nancy H. Ruddle
      Pages 75-95
    6. Disorders of the Immune System

      • Paula B. Kavathas, Peter J. Krause, Nancy H. Ruddle
      Pages 97-107
  4. IMMUNOEPIDEMIOLOGY BASICS: IMMUNOLOGY OF POPULATIONS

    1. Front Matter

      Pages 109-109
    2. Immunoepidemiology of Immune Dysfunction

      • Eric Meffre, Peter J. Krause, Nancy H. Ruddle
      Pages 127-148
  5. IMMUNOEPIDEMIOLOGY OF INFECTIOUS DISEASES AND CANCER

    1. Front Matter

      Pages 149-149
    2. Immunoepidemiology of Mycobacterium tuberculosis

      • Camila D. Odio, Richard J. Bucala
      Pages 151-163
    3. Immunoepidemiology of Human Immunodeficiency

      • Elijah Paintsil
      Pages 165-178
    4. Fungal Immunoepidemiology

      • Marwan M. Azar
      Pages 179-191
    5. Immunoepidemiology of Plasmodium falciparum malaria

      • Amy K. Bei, Sunil Parikh
      Pages 193-213
    6. Immunoepidemiology of Cancer

      • Xiaomei Ma, Rong Wang
      Pages 215-224
  6. IMMUNOEPIDEMIOLOGIC INVESTIGATIVE, THERAPEUTIC, AND PREVENTATIVE TOOLS

    1. Front Matter

      Pages 225-225
    2. Modeling Approaches Toward Understanding Infectious Disease Transmission

      • Laura A. Skrip, Jeffrey P. Townsend
      Pages 227-243

About this book

This textbook focuses on the nascent field of Immunoepidemiology that addresses how differences in immune responses among individuals affect the epidemiology of infectious diseases, cancer, hypersensitivity, and autoimmunity. The idea for the book originated from a course entitled “Immunology for Epidemiologists“ at the Yale School of Public Health. While many fine textbooks are available that address the immunological responses of individuals to pathogens, these provided very little information regarding how immunological variation among populations affects the epidemiology of disease. And yet, it has long been recognized that there is great immunologic diversity among people, which can have a profound effect on the epidemiology of disease. Careful review of the immunologic and epidemiologic literature revealed that there have been relatively few publications concerning immunoepidemiology and that no textbook is available on the subject. This textbook therefore aims to fill this void by providing a much-needed tool to comprehensively and efficiently teach immunoepidemiology. The book includes a section on the basic principles of immunology, and then applies them to particular examples of disease in human populations. The target audience for this text book are Masters of Public Health students.  Others who should also find it of interest include PhD students in epidemiology, immunology, medical students, generalists, and specialists in immunology, infectious diseases, cancer, and rheumatology.

Editors and Affiliations

  • Department of Epidemiology of Microbial Diseases, Yale School of Public Health and Departments of Medicine and Pediatrics, Yale School of Medicine, New Haven, USA

    Peter J. Krause

  • Departments of Laboratory Medicine and Immunobiology, Yale School of Medicine, New Haven, USA

    Paula B. Kavathas

  • Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, USA

    Nancy H. Ruddle

About the editors

Peter J. Krause, M.D. is a physician-scientist whose research focuses on tick-borne infections, especially human babesiosis, Borrelia miyamotoi infection, and Lyme disease. He received his MD at Tufts University School of Medicine, completed post-medical school training at Yale, Stanford, and UCLA, was a Professor of Pediatrics at the University of Connecticut School of Medicine, and is currently a Senior Research Scientist at the Yale School of Public Health and Yale School of Medicine where he teaches “Immunology for Epidemiologists”.



Paula B. Kavathas, Ph.D. is an immunologist whose research focuses on CD8 T cell immunity and immunotherapy.  She received her Ph.D. in Genetics from the University of Wisconsin, was a postdoctoral fellow at Stanford University and is currently Professor of Laboratory Medicine and Immunobiology at Yale University School of Medicine where she teaches a popular Yale College undergraduate course “Immunity and Contagion”. 


Nancy H. Ruddle, Ph.D. is an immunologist with a particular interest in cytokines and inflammation as they relate to autoimmunity and lymphoid organ development. She received her Ph.D. and did postdoctoral training at Yale University where she is a Professor at Yale School of Public Health.  She developed the first Yale course , “Immunology for Epidemiologists” and taught it for more than 35 years. 

Bibliographic Information

  • Book Title: Immunoepidemiology

  • Editors: Peter J. Krause, Paula B. Kavathas, Nancy H. Ruddle

  • DOI: https://doi.org/10.1007/978-3-030-25553-4

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2019

  • Hardcover ISBN: 978-3-030-25552-7Published: 06 November 2019

  • Softcover ISBN: 978-3-030-25555-8Published: 06 November 2020

  • eBook ISBN: 978-3-030-25553-4Published: 24 October 2019

  • Edition Number: 1

  • Number of Pages: XXVII, 297

  • Number of Illustrations: 7 b/w illustrations, 74 illustrations in colour

  • Topics: Immunology, Epidemiology, Medical Microbiology, Public Health

Buy it now

Buying options

eBook USD 69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 89.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 119.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access