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Neuroimmune Diseases

From Cells to the Living Brain

  • Innovative approach builds from basic pathogenic behavior to nerve cell dysfuction to potential diagnoses
  • Provides translational overview of the pathological mechanisms behind neuroimmune disease
  • Emphasizes the interactions between immune and nerve cells

Part of the book series: Contemporary Clinical Neuroscience (CCNE)

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Softcover Book USD 299.99
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Table of contents (27 chapters)

  1. Front Matter

    Pages i-xi
  2. Fundamental Mechanisms and General Principles

    1. Front Matter

      Pages 1-1
    2. Overview of Mechanisms Underlying Neuroimmune Diseases

      • Sandip Ashok Sonar, Girdhari Lal
      Pages 3-62
    3. Roles of Effector T Cells in Neurological Autoimmunity

      • Yuki Fujita, Toshihide Yamashita
      Pages 63-81
    4. The Role of Th17 Cells in Immunopathogenesis of Neuroinflammatory Disorders

      • Arash Pourgholaminejad, Foozhan Tahmasebinia
      Pages 83-107
    5. Significance of Autoantibodies

      • Christiane S. Hampe
      Pages 109-142
    6. Immune Tolerance in Autoimmune Central Nervous System Disorders

      • Sundararajan Jayaraman, Bellur S. Prabhakar
      Pages 143-166
    7. The Roles of Regulatory T Cells in Central Nervous System Autoimmunity

      • Brooke A. Keating, Justin G. Lees, Gila Moalem-Taylor
      Pages 167-193
    8. Multi-actions of Microglia

      • Célestine Brunois, Laurence Ris
      Pages 303-328
    9. Autoimmune Astrocytopathy

      • Jorge Correale, María I. Gaitán
      Pages 329-355
    10. Genetic Factors in Neuroimmune Diseases

      • Alessandro Didonna, Ester Cantó
      Pages 357-386
    11. General Principles of Immunotherapy in Neurological Diseases

      • Paulus S. Rommer, Michael Hecker, Tobias Zrzavy, Nina Boxberger, Uwe K. Zettl
      Pages 387-421
  3. Disorders: Diagnosis and Therapies

    1. Front Matter

      Pages 423-423
    2. Postinfectious Immune-Mediated Neurological Diseases

      • Marios Hadjivassiliou, Panagiotis Zis
      Pages 425-437
    3. Paraneoplastic Neurological Syndromes

      • Sergio Muñiz-Castrillo, Jérôme Honnorat
      Pages 439-485
    4. Multiple Sclerosis

      • Jun-ichi Kira, Noriko Isobe
      Pages 487-521
    5. Neuromyelitis Optica Spectrum Disorder

      • Samira Saadoun, Vincent T. W. Chang, Marios C. Papadopoulos
      Pages 523-541

About this book

A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases



Editors and Affiliations

  • Medical Education Promotion Center, Tokyo Medical University, Tokyo, Japan

    Hiroshi Mitoma

  • Department of Neurology, CHU-Charleroi, Charleroi, Belgium, Department of Neurosciences, University of Mons, Mons, Belgium

    Mario Manto

About the editors

Hiroshi Mitoma is Neurologist and Neurophysiologist , Professor and Chairman, Medical Education Promotion Center and Department Medical Education at Tokyo Medical University. 

Mario Manto is Neurologist, Head of the Department of Neurology at the CHU-Charleroi, Professor of Neuroanatomy and Neurological Semiology at the University of Mons. He is also teaching Pathophysiology of the Nervous System. He is the Founding Editor of The Cerebellum, Cerebellum and Ataxias and has written or edited 10 books.

Bibliographic Information

  • Book Title: Neuroimmune Diseases

  • Book Subtitle: From Cells to the Living Brain

  • Editors: Hiroshi Mitoma, Mario Manto

  • Series Title: Contemporary Clinical Neuroscience

  • DOI: https://doi.org/10.1007/978-3-030-19515-1

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2019

  • Hardcover ISBN: 978-3-030-19514-4Published: 27 August 2019

  • Softcover ISBN: 978-3-030-19517-5Published: 27 August 2020

  • eBook ISBN: 978-3-030-19515-1Published: 13 August 2019

  • Series ISSN: 2627-535X

  • Series E-ISSN: 2627-5341

  • Edition Number: 1

  • Number of Pages: XI, 827

  • Number of Illustrations: 19 b/w illustrations, 77 illustrations in colour

  • Topics: Neurosciences, Neurology

Buy it now

Buying options

eBook USD 229.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 299.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 299.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access