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Cerebrospinal Fluid Biomarkers

  • Book
  • © 2021

Overview

Editors:
  1. Charlotte E. Teunissen

    1. Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam University Medical Centre, Vrije Universiteit, Amsterdam, The Netherlands

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  2. Henrik Zetterberg

    1. Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothernburg, Mölndal, Sweden

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Neuromethods (NM, volume 168)

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Table of contents (13 protocols)

  1. Front Matter

    Pages i-xii
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  2. CSF Cells: Cell Count, Cytomorphology, Cytology, and Immunophenotyping

    • Sigurd D. Süssmuth, Hayrettin Tumani
    Pages 1-16

  3. Nephelometry and Turbidimetry: Methods to Quantify Albumin and Immunoglobulins Concentrations in Clinical Neurochemistry

    • Piotr Lewczuk
    Pages 17-27

  4. Oligoclonal Bands: Isoelectric Focusing and Immunoblotting, and Determination of κ Free Light Chains in the Cerebrospinal Fluid

    • Harald Hegen, Florian Deisenhammer
    Pages 29-54

  5. Abeta CSF LC-MS

    • Josef Pannee, Kaj Blennow, Henrik Zetterberg
    Pages 55-69

  6. Immunoassay and Mass Spectrometry Methods for Tau Protein Quantification in the Cerebrospinal Fluid

    • Christophe Hirtz, Jérôme Vialaret, Constance Delaby, Aleksandra Maleska Maceski, Cyndi Catteau, Nelly Ginestet et al.
    Pages 71-85

  7. CSF RT-QuIC and the Diagnosis of Creutzfeldt–Jakob Disease

    • Alison J. E. Green, Neil I. McKenzie
    Pages 87-127

  8. Lumbar Puncture: Consensus Guidelines

    • Pim Fijneman, Sebastiaan Engelborghs
    Pages 129-135

  9. Pre-Analytical Processing and Biobanking Protocol for CSF Samples

    • Charlotte E. Teunissen, Eline Willemse
    Pages 137-145

  10. Communicating Complex Results of Cerebrospinal Fluid Analysis

    • Axel Regeniter, Werner H. Siede
    Pages 147-162

  11. Method and Clinical Validation of Biomarkers for Neurodegenerative Diseases

    • Ulf Andreasson, Kaj Blennow, Henrik Zetterberg
    Pages 163-173

  12. Sample Preparation for Proteomic Analysis of Cerebrospinal Fluid

    • Johan Gobom
    Pages 175-180

  13. Brain Biomarkers: Follow-Up of RNA Expression Discovery Approach: CSF Assays for Neurogranin, SNAP-25, and VILIP-1

    • Elizabeth M. Herries, Nancy Brada, Courtney L. Sutphen, Anne M. Fagan, Jack H. Ladenson
    Pages 181-221

  14. Quantification of the Neurofilament Light Chain Protein by Single Molecule Array (Simoa) Assay

    • Christian Barro, Sarah Storz, Svenya Gröbke, Zuzanna Michalak, Jens Kuhle
    Pages 223-233

  15. Back Matter

    Pages 235-236
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Keywords

About this book

This volume covers the latest methods used in clinical neurochemistry laboratories for both clinical practice and research. Chapters in this book discuss topics such as techniques for cerebrospinal fluid (CSF) collection, pre-analytical processing, and basic CSF analysis; an examination of biomarkers including ELISA and automated immunochemical assays for amyloid and tau markers for Alzheimer’s disease; the analysis of neurofilaments by digital ELISA; and an example of successful novel immunoassay development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. 

Cutting-edge and thorough, Cerebrospinal Fluid Biomarkers is a valuable resource for clinicians and researchers to use in CSF labs and CSF courses.

Editors and Affiliations

  • Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam University Medical Centre, Vrije Universiteit, Amsterdam, The Netherlands

    Charlotte E. Teunissen

  • Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothernburg, Mölndal, Sweden

    Henrik Zetterberg

Bibliographic Information

  • Book Title: Cerebrospinal Fluid Biomarkers

  • Editors: Charlotte E. Teunissen, Henrik Zetterberg

  • Series Title: Neuromethods

  • DOI: https://doi.org/10.1007/978-1-0716-1319-1

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2021

  • Hardcover ISBN: 978-1-0716-1318-4Published: 05 May 2021

  • Softcover ISBN: 978-1-0716-1321-4Published: 05 May 2022

  • eBook ISBN: 978-1-0716-1319-1Published: 04 May 2021

  • Series ISSN: 0893-2336

  • Series E-ISSN: 1940-6045

  • Edition Number: 1

  • Number of Pages: XII, 236

  • Number of Illustrations: 33 b/w illustrations, 34 illustrations in colour

  • Topics: Neurosciences

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