Skip to main content
  • Book
  • © 2021

Middle Molecular Strategy

Flow Synthesis to Functional Molecules

  • Explains how to design and synthesize bioactive and functional middle-size molecules
  • Describes the synthesis of structurally complex middle-size molecules
  • Shows how to utilize recently developed methods based on flow chemistry

Buy it now

Buying options

eBook USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

This is a preview of subscription content, log in via an institution to check for access.

Table of contents (19 chapters)

  1. Front Matter

    Pages i-x
  2. Bio-functional Middle Molecules

    1. Front Matter

      Pages 1-1
    2. Conjugation Strategies for Development of Bioactive Middle Molecules

      • Yoshiyuki Manabe, Atushi Shimoyama, Kazuya Kabayama, Koichi Fukase
      Pages 3-20
    3. Mid-Sized Macrocyclic Peptides as a New Drug Modality

      • Yuki Goto, Masanobu Nagano, Hiroaki Suga
      Pages 97-107
  3. Synthetic Advances in Complex Middle Molecules

    1. Front Matter

      Pages 109-109
    2. Convergent Total Synthesis of (+)-Cotylenin A

      • Masahiro Uwamori, Ryunosuke Osada, Ryoji Sugiyama, Kotaro Nagatani, Masahisa Nakada
      Pages 111-126
    3. Electrochemical Synthesis of Oligosaccharides as Middle-Sized Molecules

      • Md. Azadur Rahman, Kumpei Yano, Sujit Manmode, Yuta Isoda, Norihiko Sasaki, Toshiyuki Itoh et al.
      Pages 127-137
  4. Synthetic Advances in Aromatic Middle Molecules

    1. Front Matter

      Pages 187-187
    2. Reaction Field for a Lewis Acid with a Tunable Factor for Selective Organic Synthesis

      • Akihito Konishi, Yoshihiro Nishimoto, Makoto Yasuda
      Pages 225-260
  5. Synthetic Advances in Flow Chemistry for Middle Molecules

    1. Front Matter

      Pages 261-261
    2. Organozinc Reagent in Flow Chemistry

      • Seijiro Matsubara
      Pages 263-273
    3. Development and Integration of New Green Reactions

      • Takashi Ohshima, Hiroyuki Morimoto, Tetsuya Kadota
      Pages 275-295

About this book

This book highlights recently discovered aspects of “middle-size molecules,” focusing on (1) their unique bio-functions on the basis of derivatives and conjugates of natural products, saccharides, peptides, and nucleotides; (2) the synthesis of structurally complex natural products; (3) special synthetic methods for π-conjugated functional molecules; and (4) novel synthetic methods using flow chemistry. Given its scope, the book is of interest to industrial researchers and graduate students in the fields of organic chemistry, medicinal chemistry, and materials science. 

Editors and Affiliations

  • Graduate School of Science, Osaka University, Toyanaka, Osaka, Japan

    Koichi Fukase

  • Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan

    Takayuki Doi

About the editors

Koichi Fukase graduated from the Department of Chemistry, Osaka University, in 1982 and received his Ph.D. from Osaka University (under Prof. Tetsuo Shiba) in 1987. After spending 1 year as a JSPS Postdoctoral Fellow (under Prof. Shiba), he was appointed as Assistant Professor (1988–1996) at the Department of Chemistry, School of Science, Osaka University (under Prof. Shoichi Kusumoto). In 1994, he joined Prof. W. Clark Still’s group at Columbia University as a Ministry of Education Research Fellow. After returning to Osaka in 1995, he was promoted to Lecturer (1996) and Associate Professor (1998) and became Full Professor at the Department of Chemistry, Graduate School of Science, Osaka University, in 2004. He received the Chemical Society of Japan Award for Creative Work in 2011. His research interests include carbohydrate chemistry and glycobiology, synthetic organic chemistry, bio-imaging, and innate immunity.

Takayuki Doi received his Ph.D. from Tokyo Techin 1991 (under Prof. Takashi Takahashi). After a postdoctoral scientist position under Prof. Gilbert Stork at Columbia University, he joined Tokyo Tech as Assistant Professor in 1993 and became Associate Professor in 2001. He was promoted to Full Professor at the Graduate School of Pharmaceutical Sciences, Tohoku University, in 2008 and joined the Graduate School of Life Sciences in 2018. He received the Progress Award in Synthetic Organic Chemistry, Japan in 2000, and the Pharmaceutical Society of Japan Award for Divisional Scientific Promotions in 2013.

Bibliographic Information

  • Book Title: Middle Molecular Strategy

  • Book Subtitle: Flow Synthesis to Functional Molecules

  • Editors: Koichi Fukase, Takayuki Doi

  • DOI: https://doi.org/10.1007/978-981-16-2458-2

  • Publisher: Springer Singapore

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2021

  • Hardcover ISBN: 978-981-16-2457-5Published: 14 July 2021

  • Softcover ISBN: 978-981-16-2460-5Published: 15 July 2022

  • eBook ISBN: 978-981-16-2458-2Published: 13 July 2021

  • Edition Number: 1

  • Number of Pages: X, 357

  • Number of Illustrations: 180 b/w illustrations, 101 illustrations in colour

  • Topics: Bioorganic Chemistry, Medicinal Chemistry, Pharmaceutical Sciences/Technology, Pharmacy

Buy it now

Buying options

eBook USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access