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Optogenetics

Light-Sensing Proteins and Their Applications in Neuroscience and Beyond

  • Book
  • © 2021

Overview

Editors:
  1. Hiromu Yawo

    1. The Institute for Solid State Physics, The University of Tokyo, Kashiwa, Japan

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  2. Hideki Kandori

    1. OptoBioTechnology Research Center, Nagoya Institute of Technology, Nagoya, Japan

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  3. Amane Koizumi

    1. National Institutes of Natural Sciences, Tokyo, Japan

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  4. Ryoichiro Kageyama

    1. Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan

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  • Reviews all aspects of optogenetics
  • Explains applications in neuroscience and medicine
  • Examines emerging directions in the field

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1293)

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Table of contents (45 chapters)

  1. Front Matter

    Pages i-xii
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  3. Light-Sensitive Signaling Molecules

    1. Front Matter

      Pages 127-127
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    2. Photoactivated Adenylyl Cyclases: Fundamental Properties and Applications

      • Mineo Iseki, Sam-Yong Park
      Pages 129-139

    3. Optogenetic Potentials of Diverse Animal Opsins: Parapinopsin, Peropsin, LWS Bistable Opsin

      • Mitsumasa Koyanagi, Tomoka Saito, Seiji Wada, Takashi Nagata, Emi Kawano-Yamashita, Akihisa Terakita
      Pages 141-151

    4. Molecular Properties and Optogenetic Applications of Enzymerhodopsins

      • Satoshi P. Tsunoda, Masahiro Sugiura, Hideki Kandori
      Pages 153-165

    5. Phytochromes and Cyanobacteriochromes: Photoreceptor Molecules Incorporating a Linear Tetrapyrrole Chromophore

      • Keiji Fushimi, Rei Narikawa
      Pages 167-187

    6. Photoreaction Mechanisms of Flavoprotein Photoreceptors and Their Applications

      • Tatsuya Iwata, Shinji Masuda
      Pages 189-206

  4. Optogenetics in Biological Systems

    1. Front Matter

      Pages 207-207
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    2. Genetically Encoded Voltage Indicators

      • Irene Mollinedo-Gajate, Chenchen Song, Thomas Knöpfel
      Pages 209-224

    3. Visualization and Manipulation of Intracellular Signaling

      • Yuhei Goto, Yohei Kondo, Kazuhiro Aoki
      Pages 225-234

    4. Light Control of Gene Expression Dynamics

      • Akihiro Isomura
      Pages 235-246

    5. Functional Modulation of Receptor Proteins on Cellular Interface with Optogenetic System

      • Mizuki Endo, Takeaki Ozawa
      Pages 247-263

    6. Genetically Encoded Photosensitizer for Destruction of Protein or Cell Function

      • Yemima Dani Riani, Tomoki Matsuda, Takeharu Nagai
      Pages 265-279
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Keywords

About this book

This book, now in a thoroughly revised second edition, offers a comprehensive review of the rapidly growing field of optogenetics, in which light-sensing proteins are genetically engineered into cells in order to acquire information on cellular physiology in optical form or to enable control of specific network in the brain upon activation by light. Light-sensing proteins of various living organisms are now available to be exogenously expressed in neurons and other target cells both in vivo and in vitro. Cellular functions can thus be manipulated or probed by light. The new edition documents fully the extensive progress since publication of the first edition to provide an up-to-date overview of the physical, chemical, and biological properties of light-sensing proteins and their application in biological systems, particularly in neuroscience but also in medicine and the optical sciences. Underlying principles are explained and detailed information provided on a wide rangeof optogenetic tools for the observation and control of cellular signaling and physiology, gene targeting technologies, and optical methods for biological applications. In presenting the current status of optogenetics and emerging directions, this milestone publication will be a “must read” for all involved in research in any way related to optogenetics.

Editors and Affiliations

  • The Institute for Solid State Physics, The University of Tokyo, Kashiwa, Japan

    Hiromu Yawo

  • OptoBioTechnology Research Center, Nagoya Institute of Technology, Nagoya, Japan

    Hideki Kandori

  • National Institutes of Natural Sciences, Tokyo, Japan

    Amane Koizumi

  • Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan

    Ryoichiro Kageyama

About the editors

Hiromu Yawo MD PhD

Tohoku University
 
Hideki Kandori PhD
Nagoya Institute of Technology
 
Amane Koizumi PhD
National Institutes of Natural Sciences
 
Ryoichiro Kageyama PhD
Kyoto University, Institute for Frontier Life and Medical Sciences

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