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Role of Signaling Pathways in Brain Tumorigenesis

  • Book
  • © 2023

Overview

Authors:
  1. Mehdi Hayat Shahi

    1. Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim University, Aligarh, India

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  • This book illustrates the details of origin of brain tumors and mechanism of progression

  • It represents a comprehensive overview of the role of various cell signaling pathways in brain tumour development

  • It illustrates the mechanism of pathway activation to tumor growth and therapeutic approach for brain tumor treatment

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Part I

    1. Front Matter

      Pages 1-1
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    2. Introduction to Cell Signaling Pathways and Brain Tumors

      • Mehdi Hayat Shahi
      Pages 3-12

  4. Part III

    1. Front Matter

      Pages 69-69
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    2. NANOG Stem Cell Marker and Its Role in Brain Tumor Development

      • Mehdi Hayat Shahi
      Pages 71-82

    3. Stem Cell Factor Sox2 and Brain Tumor Development

      • Mehdi Hayat Shahi
      Pages 83-92

    4. Role of Neurotrophins in Brain Tumor Development

      • Mehdi Hayat Shahi
      Pages 93-103

    5. Role of NF-kB in Brain Tumor Development

      • Mehdi Hayat Shahi
      Pages 105-112

  5. Part IV

    1. Front Matter

      Pages 113-113
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    2. Role of Myc in Brain Tumor Development

      • Mehdi Hayat Shahi
      Pages 115-127

    3. Role of p53 in Medulloblastoma Development

      • Mehdi Hayat Shahi
      Pages 129-141

    4. Role of TP53 Gene in Glioma

      • Mehdi Hayat Shahi
      Pages 143-153

    5. Role of HIF-1 in Brain Tumor Development

      • Mehdi Hayat Shahi
      Pages 155-166

  6. Part V

    1. Front Matter

      Pages 167-167
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    2. EGFR and Its Role in Glioma Development

      • Mehdi Hayat Shahi
      Pages 169-180
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Keywords

About this book

This book provides acomprehensive overview of cell signalling pathways and morphogens in the genesis of brain tumours. It also explains the role of brain tumour stem cells in the brain tumour progression. It also elucidates the novel early biomarkers that can be utilized to diagnose brain tumours. It presents the basic developmental pathways and morphogens, including retinoic acid and TGF-b that promote brain tumorigenesis. The chapters illustrate the role of stem cells and stem cells mediated cell signalling pathways including, Sonic hedgehog, Notch, Wnt in the brain tumour growth. The chapters also emphasize the role of transcription factors, mainlyNanog, Sox, BMI1, HIF1 and Pax6 in the brain tumouriogensis. It highlights the role of NF-kb, Myc and neurotrophins in the brain tumour development. Finally, the book summarizes the potential early therapeutic targets and targeted drug discovery for brain tumours.  

Authors and Affiliations

  • Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim University, Aligarh, India

    Mehdi Hayat Shahi

About the author

Dr. Mehdi Hayat Shahi is an Assistant Professor at the Interdisciplinary Brain Research Centre, Aligarh Muslim University, Aligarh. Before joining AMU, he was a postdoctoral fellow at University of California, Davis, USA from 2010-2014. He was also an instructor at the University California Davis besides his postdoctoral research. From 2009-2010, he worked as a postdoctoral research fellow at Uppsala University, Uppsala, Sweden. His current research interests are focused on molecular neuro-oncology. Towards this pursuit, he is exploring the early stem cell biomarkers that can be utilized for the early diagnosis of brain tumours and other neurodegenerative diseases. He has been honored with many prestigious awards notably, Farah Deeba Award from the Indian Academy of Biomedical Sciences for an outstanding researcher in biomedical sciences, Outstanding Scientist Award for Neuro-oncology research from the Venus International Foundation. He has also served as a referee for the number of international journals, including, PLoS One and Tumour Biology. He has 12 years of research experience in molecular brain tumour biology and 4 years of teaching experience.

He has published more than 21 research articles in the peer-reviewed international journals and co-authored two book chapters. He has served as a Co-chair of the Post-doctoral Scholar Association, University of California, USA, from 2013-2014. He is a member of many International Scientific Societies and Organizations importantly International Society for Neurochemistry, Indian Academy of Neurosciences, Indian Association for Cancer Research, and Indian Academy of Biomedical Sciences.

Bibliographic Information

  • Book Title: Role of Signaling Pathways in Brain Tumorigenesis

  • Authors: Mehdi Hayat Shahi

  • DOI: https://doi.org/10.1007/978-981-15-8473-2

  • Publisher: Springer Singapore

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2023

  • Hardcover ISBN: 978-981-15-8472-5Published: 21 November 2023

  • Softcover ISBN: 978-981-15-8475-6Due: 05 December 2024

  • eBook ISBN: 978-981-15-8473-2Published: 20 November 2023

  • Edition Number: 1

  • Number of Pages: XIII, 218

  • Number of Illustrations: 1 b/w illustrations

  • Topics: Cancer Research, Neurobiology, Gene Expression, Cytokines and Growth Factors

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