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Drug Discovery and Development

From Targets and Molecules to Medicines

  • Book
  • © 2021

Overview

Editors:
  1. Ramarao Poduri

    1. Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, India

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  • Explains the various phases of drug discovery and development
  • Simplifies the complex process of drug discovery and development
  • Establishes a connect between academia and industry

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-viii
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  2. Historical Perspective of Drug Discovery and Development

    • Ramarao Poduri
    Pages 1-10

  3. Natural Products: Drug Discovery and Development

    • Inder Pal Singh, Furkan Ahmad, Debanjan Chatterjee, Ruchi Bajpai, Neha Sengar
    Pages 11-65

  4. The Concept of Receptor and Molecule Interaction in Drug Discovery and Development

    • Ramarao Poduri, Gowraganahalli Jagadeesh
    Pages 67-102

  5. Dynamic Axial Chirality in Drug Design and Discovery: Introduction to Atropisomerism, Classification, Significance, Recent Trends and Challenges

    • Gaurav Joshi, Manpreet Kaur, Raj Kumar
    Pages 103-124

  6. Biased Agonism: Renewing GPCR’s Targetability for the Drug Discovery

    • Ravinder Reddy Gaddam, Ajit Vikram
    Pages 125-136

  7. Computer-Aided Drug Design

    • Prasad V. Bharatam
    Pages 137-210

  8. Pharmacological Screening: Drug Discovery

    • Kumar V. S. Nemmani
    Pages 211-233

  9. Drug Target Identification and Validation

    • Srinivas Gullapalli
    Pages 235-249

  10. Genetics and Drug Discovery

    • Aruna Poduri, Amit Khanna
    Pages 251-266

  11. Discovery and Development of Stem Cells for Therapeutic Applications

    • Arun H. S. Kumar
    Pages 267-296

  12. Pharmacokinetics: Theory and Application in Drug Discovery and Development

    • Pradeep Sharma, Nikunjkumar Patel, Bhagwat Prasad, Manthena V. S. Varma
    Pages 297-355

  13. Regulatory Toxicology Testing of Pharmaceuticals

    • Venkatesha Udupa, K. S. Rao
    Pages 357-392

  14. Nanomedicine: Implications of Nanotoxicology

    • Mohd Aslam Saifi, Ramarao Poduri, Chandraiah Godugu
    Pages 393-415

  15. Clinical Research in Pharmaceutical Drug Development

    • Srinivas Ghatta, Michelle Niewood
    Pages 417-434

  16. Pharmacovigilance

    • Pramil Tiwari, Prity Rani Deshwal
    Pages 435-449

  17. Regulatory Process for New Drug Approval in India

    • K. Bangarurajan
    Pages 451-463

  18. Pharmaceutical Industry, Academia, Regulatory Authorities and End User Collaboration in Successful Drug Discovery and Development

    • Ramarao Poduri
    Pages 465-471

  19. Statistics in Pharmacology and Toxicology

    • Mohammad Atiar Rahman, Karl Lin
    Pages 473-522
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Keywords

About this book

This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing.

Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.



Editors and Affiliations

  • Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, India

    Ramarao Poduri

About the editor

Dr. Ramarao Poduri, M Pharm, PhD, is currently working as Dean of Academic Affairs, Dean of the School of Basic and Applied Sciences, and a Professor at the Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, India. Dr. Poduri graduated from the Banaras Hindu University of India and completed his postdoctoral research at the University of Illinois, Chicago and Harvard Medical School, Boston. With more than 40 years of teaching experience, he has worked at various prestigious institutes, including Banaras Hindu University, NIPER, S.A.S. Nagar and the Central University of Punjab. Dr. Poduri has published more than 140 peer-reviewed research papers and received e.g. the ISCB Award for Excellence (2009), Indian Society of Chemists & Biologists Pharma-Bio Award (2009), and IASTAM Dr. K.M. Parikh Award (2018). 

Bibliographic Information

  • Book Title: Drug Discovery and Development

  • Book Subtitle: From Targets and Molecules to Medicines

  • Editors: Ramarao Poduri

  • DOI: https://doi.org/10.1007/978-981-15-5534-3

  • Publisher: Springer Singapore

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2021

  • Hardcover ISBN: 978-981-15-5533-6Published: 16 February 2021

  • Softcover ISBN: 978-981-15-5536-7Published: 17 February 2022

  • eBook ISBN: 978-981-15-5534-3Published: 15 February 2021

  • Edition Number: 1

  • Number of Pages: VIII, 522

  • Number of Illustrations: 81 b/w illustrations, 46 illustrations in colour

  • Topics: Pharmaceutical Sciences/Technology, Medicinal Chemistry, Pharmacy

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