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Frontiers in Protein Structure, Function, and Dynamics

Herausgeber: Singh, Dev Bukhsh, Tripathi, Timir (Eds.)

Vorschau
  • Presents methods to determine protein stability 
  • Emphasizes the role of protein misfolding in neurodegenerative diseases
  • Reviews methods to determine three-dimensional structure of the protein and to understand protein-protein interaction
Weitere Vorteile

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  • ISBN 978-981-15-5530-5
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Über dieses Buch

This book discusses a broad range of basic and advanced topics in the field of protein structure, function, folding, flexibility, and dynamics. Starting with a basic introduction to protein purification, estimation, storage, and its effect on the protein structure, function, and dynamics, it also discusses various experimental and computational structure determination approaches; the importance of molecular interactions and water in protein stability, folding and dynamics; kinetic and thermodynamic parameters associated with protein-ligand binding; single molecule techniques and their applications in studying protein folding and aggregation; protein quality control; the role of amino acid sequence in protein aggregation; muscarinic acetylcholine receptors, antimuscarinic drugs, and their clinical significances.

Further, the book explains the current understanding on the therapeutic importance of the enzyme dopamine beta hydroxylase; structural dynamics and motions in molecular motors; role of cathepsins in controlling degradation of extracellular matrix during disease states; and the important structure-function relationship of iron-binding proteins, ferritins. Overall, the book is an important guide and a comprehensive resource for understanding protein structure, function, dynamics, and interaction.

Über die Autor*innen

Dr. Dev Bukhsh Singh is an Assistant Professor at the Department of Biotechnology, Chhatrapati Shahu Ji Maharaj University, India. He received his Ph.D. in Biotechnology from Gautam Buddha University, India, after completing his B.Sc. and M.Sc. degrees at the University of Allahabad, Prayagraj, and M.Tech. in Bioinformatics at the Indian Institute of Information Technology, Prayagraj, India. He has been actively involved in teaching and research since 2009, particularly in the areas of molecular modeling, chemoinformatics, inhibitor/drug design, and in silico evaluation. He has authored many research and review articles and book chapters in the fields of medicinal research, molecular modeling, drug design, and systems biology. He is a member of various national and international academic and research organizations, and has served as a referee for several international journals published by Springer, Bentham Science, and Taylor & Francis. 

Dr. Timir Tripathi is a Senior Assistant Professor at the Department of Biochemistry, North-Eastern Hill University, Shillong, India. He obtained his Ph.D. degree from the Central Drug Research Institute, Lucknow in 2010. He was a visiting faculty at ICGEB, New Delhi, India (2011), and KhonKaen University, Thailand (2015). His research interests are focused on understanding the structure-function-folding-misfolding-aggregation-flexibility-dynamics relations in proteins. He has done pioneering work on the protein-substrate interaction & dynamics, and understanding the roles of non-catalytic domains in regulating the catalytic activity of key drug target proteins. His work has provided a platform for the development of novel therapeutic strategies. He has received various awards including the Dr. D.M. Bose Award (2008), DST Fast Track Young Scientist Project Award (2012), DBT Overseas Associateship Award (2012), BRSI- Malviya Memorial Award (2017), ICMR- Shakuntala Amir Chand Prize (2018), and ISCB-Young Scientist Award (2019). In 2019, he was elected as a member of the National Academy of Sciences, India (NASI) and the Royal Society of Biology (RSB), London. He has published more than 70 research papers, reviews, commentaries and viewpoint articles in highly respected international journals. He has handled ten research grants as PI from various national and international funding agencies including the DBT, DST, SERB, UGC, ICMR, Russian Foundation for Basic Research, and Israel Science Foundation. He serves on the editorial boards of several journals including Scientific Reports (Nature Publishing Group) and Plos One. He is a Management Council Member of the Biotech Research Society of India (BRSI), and of the Bioinformatics and Drug Discovery Society (BIDDS), India.

Inhaltsverzeichnis (18 Kapitel)

Inhaltsverzeichnis (18 Kapitel)
  • Protein Purification, Estimation, Storage, and Effect on Structure–Function–Dynamics

    Seiten 1-22

    Kumar, Awanish

  • Experimental and Computational Methods to Determine Protein Structure and Stability

    Seiten 23-55

    Mutharasappan, Nachiappan (et al.)

  • Wet-Lab Approaches to Determine Three-Dimensional Structures of Proteins

    Seiten 57-70

    Pandey, Rajan Kumar (et al.)

  • Use of Group-Specific Reagents in Active Site Functional Group Elucidation I: Cys, Ser, Tyr, and Trp Residues

    Seiten 71-94

    Ambasht, Pravin Kumar

  • Use of Group-Specific Reagents in Active Site Functional Group Elucidation II: Asp, Glu, Arg, Lys, and His Residues

    Seiten 95-117

    Ambasht, Pravin Kumar

Dieses Buch kaufen

eBook 117,69 €
Preis für Deutschland (Brutto)
  • ISBN 978-981-15-5530-5
  • Versehen mit digitalem Wasserzeichen, DRM-frei
  • Erhältliche Formate: PDF, EPUB
  • eBooks sind auf allen Endgeräten nutzbar
  • Sofortiger eBook Download nach Kauf
Hardcover 160,49 €
Preis für Deutschland (Brutto)
  • ISBN 978-981-15-5529-9
  • Kostenfreier Versand für Individualkunden weltweit
  • Kostenloser Sofortzugriff, sofern verfügbar* auf die eBook-Version bei jeder Buchbestellung
  • Gewöhnlich versandfertig in 3-5 Werktagen.
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Bibliografische Information

Bibliographic Information
Buchtitel
Frontiers in Protein Structure, Function, and Dynamics
Herausgeber
  • Dev Bukhsh Singh
  • Timir Tripathi
Copyright
2020
Verlag
Springer Singapore
Copyright Inhaber
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-15-5530-5
DOI
10.1007/978-981-15-5530-5
Hardcover ISBN
978-981-15-5529-9
Auflage
1
Seitenzahl
XII, 452
Anzahl der Bilder
17 schwarz-weiß Abbildungen, 54 Abbildungen in Farbe
Themen

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