Overview
- reviewing the cutting-edge research development linking aluminum neurotoxicity with cognitive impairment and Alzheimer’s disease
- focusing on aluminum levels in brain, region-specific and subcellular distribution, and its relation to neurofibrillary tangles and amyloid beta
- highlighting detailed mechanisms of aluminum in oxidative stress and cell death, especially about apoptosis and necroptosis
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1091)
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Table of contents (10 chapters)
Keywords
About this book
This book reviews the scientific literature and the authors’ own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer’s disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, and its relation to neurofibrillary tangles and amyloid beta. Further, the book stresses the importance of aluminum’s complex speciation chemistry in relation to biology, and details aluminum’s mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metal’s debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed. In closing, the book reviews the neurotoxic effects of aluminum and its important role in the pathogenesis of AD. Given its depth of coverage, the book provides readers with a systematic summary of aluminum neurotoxicity.
Editors and Affiliations
About the editor
Dr. Qiao Niu is a professor and director of the Department of Occupational Health, School of Public Health, Shanxi Medical University. He is also director of the Institute of Preventive Medicine at the same university. Dr. Niu is executive director of the Chinese Society for Toxicology, and of the Labor Health and Occupational Disease Branch of the Chinese Preventive Medicine Association. His research focuses on neurotoxicology, an area in which he has published more than 100 research articles.
Bibliographic Information
Book Title: Neurotoxicity of Aluminum
Editors: Qiao Niu
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-981-13-1370-7
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2018
Softcover ISBN: 978-981-13-4621-7Published: 30 January 2019
eBook ISBN: 978-981-13-1370-7Published: 12 October 2018
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: VII, 191
Number of Illustrations: 12 b/w illustrations, 13 illustrations in colour
Topics: Neurosciences, Pharmacology/Toxicology, Neurobiology