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Antioxidants and Cardiovascular Disease

  • Book
  • © 2000

Overview

Editors:
  1. Jean-Claude Tardif

    1. Montreal Heart Institute, Research Center and Department of Medicine, Faculty of Medicine, University of Montreal, Montreal, Canada

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  2. Martial G. Bourassa

    1. Montreal Heart Institute, Research Center and Department of Medicine, Faculty of Medicine, University of Montreal, Montreal, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 233)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xii
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  2. Lipoproteins and Oxidation: Clinical Aspects of Lipoprotein Metabolism and Oxidation

    • H. Robert Superko
    Pages 1-18

  3. Pathogenesis of Atherosclerosis

    • Richard Gallo, Valentin Fuster
    Pages 19-46

  4. The Antioxidant Hypothesis

    • Marc Forgione, Joseph Loscalzo
    Pages 47-56

  5. Reactive Oxygen Species as Mediators of Signal Transduction in Cardiovascular Disease

    • Jun-ichi Abe, Bradford C. Berk
    Pages 57-70

  6. Pharmaceutical Compounds with Antioxidant Activity

    • Aalt Bast, Guido R. M. M. Haenen
    Pages 71-83

  7. Nutrition and Antioxidants

    • Paolo Rubba, Mario Mancini
    Pages 85-100

  8. Antioxidants and Vascular Disease: Animal Studies

    • John F. Keaney Jr.
    Pages 101-116

  9. Antioxidants and Endothelial Function: Human Studies

    • Christian Binggeli, Isabella Sudano, Georg Noll, Thomas F. Lüscher
    Pages 117-134

  10. Antioxidant Vitamins and Cardiovascular Disease: Evidence from Observational Epidemiologic Studies and Randomized Trials

    • William G. Christen, Charles H. Hennekens
    Pages 135-144

  11. A Rationale for Antioxidant Use in Cardiovascular Disease

    • R. Preston Mason
    Pages 145-159

  12. Antioxidants and Restenosis: Animal Studies

    • Antoine Lafont, François Vinchon, Faouzi Addad, Eric Durand
    Pages 161-174

  13. Antioxidants and Restenosis — Human Studies

    • Jean-Claude Tardif, Jean Grégoire, Martial G. Bourassa
    Pages 175-191

  14. Role of Oxidative Stress, Cytokines, and Apoptosis in Myocardial Dysfunction

    • Douglas B. Sawyer, Wilson S. Colucci
    Pages 193-209

  15. Oxidative Stress and Use of Antioxidants in Patients with Congestive Heart Failure

    • Michel White, Jean-Claude Tardif, Martial G. Bourassa
    Pages 211-224

  16. Use of Antioxidants in Cardiovascular Medicine

    • Jawahar L. Mehta, Dayuan Li, Jason Mehta
    Pages 225-238

  17. Back Matter

    Pages 239-258
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Keywords

About this book

Generation of oxidants or reactive oxygen species is a natural process of human biology. Mitochondrial respiration, phagocytic activity and cyclooxygenase activation are all essential processes of life, which also generate oxidative species. In humans, chronic oxidative stress often coupled with deficiency of antioxidant defenses is associated with the aging process and can lead to the development of disorders such as cancer and arterial disease. Major cardiovascular conditions in which oxidative damage has been strongly implicated include atherosclerosis, myocardial ischemia and reperfusion, coronary restenosis and congestive heart failure. Compelling evidence points to oxidative stress as an important trigger in the complex chain of events leading to atherosclerosis. The expression of chemotactic factors and adhesion molecules is modified by oxidative stress. Exposure to superoxide ions activates the NF-kappa B regulatory complex and triggers the transcription of several atherosclerosis­ related genes. These events lead to the accumulation of macrophages in the arterial wall. Macrophages avidly incorporate oxidized low-density lipoproteins (LDL) to form foam cells. The activity of matrix metalloproteinases is also regulated by oxidative stress. This activity appears to be closely coupled with smooth muscle cell activation and migration. Matrix metalloproteinases have also been implicated in the pathophysiology of plaque rupture. Antioxidant supplementation including vitamin E decreases susceptibility ofLDL to oxidation and retards the progression of atherosclerosis in animal models.

Editors and Affiliations

  • Montreal Heart Institute, Research Center and Department of Medicine, Faculty of Medicine, University of Montreal, Montreal, Canada

    Jean-Claude Tardif, Martial G. Bourassa

Bibliographic Information

  • Book Title: Antioxidants and Cardiovascular Disease

  • Editors: Jean-Claude Tardif, Martial G. Bourassa

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-94-011-4375-2

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media Dordrecht 2000

  • Softcover ISBN: 978-94-010-5881-0Published: 14 October 2012

  • eBook ISBN: 978-94-011-4375-2Published: 06 December 2012

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: XII, 258

  • Topics: Cardiology, Biochemistry, general, Nutrition, Epidemiology

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