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Heat Shock Factor

  • Book
  • © 2016

Overview

Editors:
  1. Akira Nakai

    1. Department of Biochemistry & Molecular Biology, Yamaguchi University School of Medicine, Ube, Japan

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  • Provides detailed descriptions of HSF biology and physiology, as well as diseases related to its function.

  • Includes numerous schematic diagrams and tables to facilitate readers’ systematic understanding.

  • Offers basic, understandable information for undergraduate students.

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-viii
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  2. The Basis of HSF Biology

    1. Front Matter

      Pages 1-1
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    2. Proteostasis and Adaptation to High Temperature Stress

      • Akira Nakai
      Pages 3-29

    3. Structure and Function of the HSF Family Members

      • Ryosuke Takii, Mitsuaki Fujimoto
      Pages 31-50

    4. Regulation of HSF Activation and Repression

      • Eiichi Takaki, Akira Nakai
      Pages 51-72

    5. Transcriptional Regulation by HSF

      • Mitsuaki Fujimoto
      Pages 73-89

  3. Physiological Roles of HSF

    1. Front Matter

      Pages 91-91
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    2. HSF1 Regulation in Aging and Its Role in Longevity

      • Netta Shemesh, Anat Ben-Zvi
      Pages 93-113

    3. HSF Modulates Neural Development Under Normal and Stress Conditions

      • Seiji Ishii, Kazue Hashimoto-Torii
      Pages 115-129

    4. HSF Maintains Sensory Organs

      • Kazuma Sugahara, Ke Tan, Akira Nakai, Hiroshi Yamashita
      Pages 131-146

    5. HSF Is Required for Gametogenesis

      • Koji Shiraishi
      Pages 147-164

    6. HSF Regulates Immune and Inflammatory Response

      • Sachiye Inouye
      Pages 165-196

    7. Heat Shock Factors Modulate Circadian Rhythms

      • Tsuyoshi Hirota, Yoshitaka Fukada
      Pages 197-209

  4. Diseases Associated with HSF Function

    1. Front Matter

      Pages 211-211
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    2. HSF Inhibits the Progression of Age-Related Neurodegenerative Diseases

      • Naohide Kondo, Masahisa Katsuno, Yuichi Riku, Gen Sobue
      Pages 213-242

    3. HSF and Heart Diseases

      • Jie Yuan, Yunzeng Zou
      Pages 243-259

    4. HSF Supports Cancer

      • Makoto Chuma
      Pages 261-275

    5. HSF1 Activation by Small Chemical Compounds for the Treatment of Neurodegenerative Diseases

      • Nobuhiro Fujikake, Toshihide Takeuchi, Yoshitaka Nagai
      Pages 277-292

  5. Back Matter

    Pages 293-301
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Keywords

About this book

This book presents a large amount of information related to the heat shock response and heat shock factor (HSF), describes core observations about molecular mechanisms and pathophysiological roles, and provides fundamental concepts on the basis of information from diverse aspects. This adaptive response to high temperature or protein misfolding is a fundamental mechanism to maintain the capacity of protein homeostasis, or proteostasis, and is evolutionally conserved among all living organisms, including bacteria and humans, on the earth. Furthermore, physiological and pathological roles of HSF have been extensively studied in fruit fly, worm, and mouse models. It has been revealed that HSF plays roles in development of the brain, reproductive and sensory organs, and in ageing, inflammation, and circadian rhythm. Analysis of the mechanisms have uncovered that HSF exerts a wide range of effects on gene expression and epigenetic status on the whole genome. Moreover, loss or gain of HSF function is also closely related to protein-misfolding diseases including neurodegenerative diseases, psychiatric diseases, heart diseases, and cancers. Therefore, HSF is now thought to be a promising therapeutic target for treatment of these refractory diseases.
For undergraduate students, this is a highly understandable source of information on heart shock response and HSF, covering the basis of HSF biology, the physiological role of HSF, and disease associated with HSF function. This book not only serves as a guide to the heat shock response and HSF for students and young researchers in other fields, but also is a cornerstone for future work in the field related to the heat shock response and HSF.


Editors and Affiliations

  • Department of Biochemistry & Molecular Biology, Yamaguchi University School of Medicine, Ube, Japan

    Akira Nakai

About the editor


Bibliographic Information

  • Book Title: Heat Shock Factor

  • Editors: Akira Nakai

  • DOI: https://doi.org/10.1007/978-4-431-55852-1

  • Publisher: Springer Tokyo

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Japan 2016

  • Hardcover ISBN: 978-4-431-55850-7Published: 19 January 2016

  • Softcover ISBN: 978-4-431-56711-0Published: 31 March 2018

  • eBook ISBN: 978-4-431-55852-1Published: 06 January 2016

  • Edition Number: 1

  • Number of Pages: VIII, 301

  • Number of Illustrations: 59 b/w illustrations, 14 illustrations in colour

  • Topics: Cell Biology, Protein Science, Human Physiology, Animal Biochemistry

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