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Interleukin-10 in Health and Disease

  • Book
  • © 2014

Overview

Editors:
  1. Simon Fillatreau

    1. Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany

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  2. Anne O'Garra

    1. Div. of Immunoregulation, The MRC National Institute for Medical Research, London, United Kingdom

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Presents an in-depth and global analysis of how IL-10 contributes to immunity
  • Offers a set of reviews dedicated to the biology of IL-10
  • Provides a comprehensive overview on one of the most important anti-inflammatory cytokines
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 380)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-viii
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  2. IL-10 in Humans: Lessons from the Gut, IL-10/IL-10 Receptor Deficiencies, and IL-10 Polymorphisms

    • Karin R. Engelhardt, Bodo Grimbacher
    Pages 1-18

  3. Control of Intestinal Inflammation by Interleukin-10

    • Abhisake Kole, Kevin J. Maloy
    Pages 19-38

  4. Tr1 Cells and the Counter-Regulation of Immunity: Natural Mechanisms and Therapeutic Applications

    • Maria Grazia Roncarolo, Silvia Gregori, Rosa Bacchetta, Manuela Battaglia
    Pages 39-68

  5. Interleukin-10-Producing B Cells and the Regulation of Immunity

    • Ellen Hilgenberg, Ping Shen, Van Duc Dang, Stefanie Ries, Imme Sakwa, Simon Fillatreau
    Pages 69-92

  6. Pathogen Manipulation of cIL-10 Signaling Pathways: Opportunities for Vaccine Development?

    • Meghan K. Eberhardt, Peter A. Barry
    Pages 93-128

  7. IL-10: Achieving Balance During Persistent Viral Infection

    • Cherie T. Ng, Michael B. A. Oldstone
    Pages 129-144

  8. The Role of microRNAs in the Control and Mechanism of Action of IL-10

    • Susan R. Quinn, Luke A. O’Neill
    Pages 145-155

  9. The Regulation of IL-10 Expression

    • Leona GabryÅ¡ová, Ashleigh Howes, Margarida Saraiva, Anne O’Garra
    Pages 157-190

  10. The Molecular Basis of IL-10 Function: from Receptor Structure to the Onset of Signaling

    • Mark R. Walter
    Pages 191-212

  11. Role of IL-22 in Microbial Host Defense

    • Celine Eidenschenk, Sascha Rutz, Oliver Liesenfeld, Wenjun Ouyang
    Pages 213-236

  12. Back Matter

    Pages 237-238
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Keywords

About this book

This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date.

Editors and Affiliations

  • Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany

    Simon Fillatreau

  • Div. of Immunoregulation, The MRC National Institute for Medical Research, London, United Kingdom

    Anne O'Garra

Bibliographic Information

  • Book Title: Interleukin-10 in Health and Disease

  • Editors: Simon Fillatreau, Anne O'Garra

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-662-43492-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2014

  • Hardcover ISBN: 978-3-662-43491-8Published: 28 July 2014

  • Softcover ISBN: 978-3-662-52405-3Published: 23 August 2016

  • eBook ISBN: 978-3-662-43492-5Published: 08 July 2014

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: VIII, 238

  • Number of Illustrations: 16 illustrations in colour

  • Topics: Immunology, Cytokines and Growth Factors, Molecular Medicine

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