Advances in Anatomy, Embryology and Cell Biology

Neuroanatomy and Pathology of Sporadic Parkinson's Disease

Autoren: Braak, Heiko, Del Tredici, Kelly

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Über dieses Buch

The proteinopathy sporadic Parkinson’s disease (sPD) is the second most frequent degenerative disorder of the human nervous system after Alzheimer’s disease. The a -synuclein inclusion body pathology (Lewy pathology) associated with sPD is distributed throughout the central, peripheral, and enteric nervous systems. The resulting nonrandom neuronal dysfunction and, in some regions, neuronal loss is reflected by a distinctive topographic distribution pattern of the Lewy pathology that, in the brain, has been staged. Except for olfactory structures and spinal cord constituents of the pain system, sensory components of the nervous system remain uninvolved or virtually intact. The most disease-related damage revolves around motor areas – particularly around superordinate centers of the limbic and visceromotor systems as well as portions of the somatomotor system. Vulnerable regions are interconnected anatomically and susceptible nerve cell types are not neurotransmitter-dependent.

Not all clinical symptoms emerging in the course of sPD can be explained by a lack of dopamine in the nigrostriatal system. These include autonomic dysfunction, pain, hyp- or anosmia, excessive daytime sleepiness, REM sleep behavioral disorder, depression, anxiety, cognitive decline, and dementia. Against the background of the normal morphology and anatomy, the authors analyze the pathoanatomy of sPD in the nervous system at various neuropathological stages and summarize the potential functional consequences of the lesions.

Inhaltsverzeichnis (10 Kapitel)

Inhaltsverzeichnis (10 Kapitel)

Dieses Buch kaufen

eBook 117,69 €
Preis für Deutschland (Brutto)
  • ISBN 978-3-540-79850-7
  • Versehen mit digitalem Wasserzeichen, DRM-frei
  • Erhältliche Formate: PDF
  • eBooks sind auf allen Endgeräten nutzbar
  • Sofortiger eBook Download nach Kauf
Softcover 149,79 €
Preis für Deutschland (Brutto)
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Bibliografische Information

Bibliographic Information
Buchtitel
Neuroanatomy and Pathology of Sporadic Parkinson's Disease
Autoren
Titel der Buchreihe
Advances in Anatomy, Embryology and Cell Biology
Buchreihen Band
201
Copyright
2009
Verlag
Springer-Verlag Berlin Heidelberg
Copyright Inhaber
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-79850-7
DOI
10.1007/978-3-540-79850-7
Softcover ISBN
978-3-540-79849-1
Buchreihen ISSN
0301-5556
Auflage
1
Seitenzahl
VII, 119
Anzahl der Bilder
29 Abbildungen in Farbe
Themen