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Quantitative Mathematical Models in Radiation Biology

Proceedings of the Symposium at Schloss Rauisch-Holzhausen, FRG, July 1987

  • Conference proceedings
  • © 1988

Overview

Editors:
  1. Jürgen Kiefer

    1. Strahlenzentrum der Justus-Liebig-Universität, Gießen, Germany

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Table of contents (17 papers)

  1. Front Matter

    Pages I-VIII
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  2. Prelude: Why and to What End Mathematical Models in Radiation Biology

    • J. Kiefer
    Pages 1-2

  3. Models of Cellular Radiation Action — An Overview

    • K. J. Weber
    Pages 3-27

  4. Finestructures of Energy Deposition — Introductory Remarks

    • Jürgen Kiefer, Michael Kost
    Pages 29-39

  5. Analytics Required by the Multiple Nature of Radiation Effects in Cells

    • E. L. Powers
    Pages 41-48

  6. Problems in Theoretical Track Structure Research for Heavy Charged Particles

    • Herwig G. Paretzke
    Pages 49-56

  7. Radiobiological Modeling Based On Track Structure

    • Robert Katz
    Pages 57-83

  8. The Role of Energy Distributions of Charged Particles in the Mutagenic Radiation Action

    • S. Kozubek, E. A. Krasavin, K. G. Amirtayev, B. Tokarova, L. P. Chernenko, M. Bonev
    Pages 85-95

  9. Relative Biological Effectiveness: Review of a Model

    • K. Günther, W. Schulz
    Pages 97-110

  10. Saturation in Dual Radiation Action

    • H. H. Rossi, M. Zaider
    Pages 111-118

  11. Hit-Size Effectiveness Approach in Biophysical Modeling

    • Matesh N. Varma, Victor P. Bond
    Pages 119-124

  12. Interpreting Survival Observations Using Phenomenological Models

    • J. M. Nelson, L. A. Braby, N. F. Metting, W. C. Roesch
    Pages 125-134

  13. Cluster Theory of the Effects of Ionizing Radiations

    • C. A. Tobias, E. Goodwin, E. A. Blakely
    Pages 135-136

  14. The Lethal and Potentially Lethal Model — A Review and Recent Development

    • Stanley B. Curtis
    Pages 137-146

  15. DNA Double-Strand Breaks and their Relation to Cytoxicity

    • K. H. Chadwick, H. P. Leenhouts, E. Wijngaard, M. J. Sijsma
    Pages 147-158

  16. The pairwise lesion interaction model

    • Dietrich Harder
    Pages 159-170

  17. A Repair Fixation Model Based on Classical Enzyme Kinetics

    • Jürgen Kiefer
    Pages 171-179

  18. Formal, Empirical and Mechanistic Equations in Cellular Radiation Biology

    • Robert H. Haynes
    Pages 181-199

  19. Back Matter

    Pages 200-200
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Keywords

About this book

Radiation is the one agent among all environmental factors which may damage biological systems that is not only easily quantifiable but can also be measured with unsurpassed resolution. Its primary effects on atoms and molecules are well understood, and the secondary processes can be followed by sophisticated experimental techniques. The quantum nature of interactions and the importance of stochastic variations call for an exact mathematical description. This task is by no means simple, and presents a challenge both to the experimentalist and to the theoretician. It is hoped that a generally acceptable formalism will help to quantify radiation responses, both in radiation protection and radiation therapy, and make it possible to move from a purely empirical approach with all its fallacies to real understanding.

Editors and Affiliations

  • Strahlenzentrum der Justus-Liebig-Universität, Gießen, Germany

    Jürgen Kiefer

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