Tissue Engineering and Regeneration
cover

Vascularization for Tissue Engineering and Regenerative Medicine

Herausgeber: Holnthoner, W., Banfi, A., Kirkpatrick, J., Redl, H. (Eds.)

  • Discusses both fundamental and cutting-edge research
  • Includes contributions from the TERMIS community
  • Written by international experts in the field
Weitere Vorteile

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Über dieses Buch

This reference work presents the basic principles of angiogenesis induction, including the roles of signaling factors such as hypoxia-inducible factors, biophysical stimulation and angiogenic cells. The book also covers lymphogenesis induction. Both the established fundamentals in the field as well as new trends in the vascularization of engineered tissues are discussed. These include pre-vascularization strategies using preparation of channeled scaffolds and preparation of decellularized blood vessel trees, approaches to inducing formation of microvasculature and approaches to inducing the growth of vascular networks. The authors expand on these concepts with current studies of dual-level approaches to engineer vascularized tissue composites. The book concludes with a discussion of current clinical approaches and the use of vascular grafts in the context of providing clinical practice with new tissue engineering strategies.

Über die Autor*innen

Wolfgang Holnthoner obtained both his M.Sc. in 180 microbiology and genetics and his Ph.D. in molecular 181 biology from the University of Vienna, Austria. For 182 more than 20 years he has been working on endothelial 183 cells, both from blood and lymphatic vessel origin. After 184 his postdoctoral training with Kari Alitalo at the Uni185 versity of Helsinki, Finland, where he has been explor186 ing signal transduction in lymphatic endothelial cells, 187 he started at the Ludwig-Boltzmann-Institute for 188 Experimental and Clinical Traumatology to work on 189 strategies for pre-vascularization of tissue-engineered 190 constructs. He is interested in the basic functions of 191 endothelial cells in vasculogenesis, angiogenesis, and 192 lymphangiogenesis. His group’s primary focus is the 193 regeneration/engineering of microvascular structures. 194 To this aim, he employs co-culturing primary endothe195 lial cells with supporting cell types to achieve functional xiii 196 oxygen and nutrient support of tissues. Dr. Holnthoner 197 uses the physiological and biocompatible scaffold fibrin 198 to provide cells the necessary 3D environment for 199 microvascularization. In addition, his research involves 200 the integration of lymphatic vessels, since they are the 201 ones that transport the interstitial fluid in tissues back to 202 the blood circulation, and without them, human life 203 would be inconceivable. Moreover, he strives to explore 204 the emerging role of extracellular vesicles (EV) in 205 intercellular communication. These efforts contribute 206 to the development of therapies aimed for regeneration 207 208 of diseased tissues.

Andrea Banfi directs the Cell and Gene Therapy research group at the University Hospital of Basel, Switzerland. He previously worked in Genova (Italy) and Stanford (CA, USA). His research focuses on: 1) understanding the basic principles governing the growth of blood vessels, particularly the molecular crosstalk between endothelium, mural cells and inflammatory monocytes, in order to identify druggable targets for therapeutic vascular growth; and 2) translating these concepts into novel regenerative medicine approaches, particularly to generate vascularized tissue-engineered grafts and to treat ischemic diseases.

James Kirkpatrick has a triple doctorate in science 211 and medicine (M.D., Ph.D., D.Sc.) from the Queen’s 212 University of Belfast (N. Ireland) and was chairman and 213 professor of pathology at the University Medical Center 214 of the Johannes Gutenberg University (JGU) in Mainz 215 from 1993 to 2015. His prior academic appointments 216 were in pathology at the University of Ulm (1980– 217 1985), Manchester University, UK (1985–1987), and 218 RWTH (University of Technology), Aachen (1987– 219 1993). He is a fellow of the Royal College of Patholo220 gists (FRCPath), London (since 1997), and has honorary 221 and visiting professorships in Sweden, China, Singa222 pore, and Cuba. Currently, he is distinguished visiting 223 fellow at the University of Cambridge, UK, and distin224 guished professor at the Johann Wolfgang Goethe Uni225 versity in Frankfurt, where his current research is being 226 carried out. 227 His principal research interests are in life science 228 aspects of biomaterials in tissue engineering and regen229 erative medicine, with special focus on human 230 co-culture systems to study vascularization. A special 231 methodological emphasis in his research over the past 232 30 years has been the development of in vitro cellular 233 systems which have complexity well beyond the simple 234 monocellular system. Thus, how non-vascular cells con235 tribute to the proliferation, differentiation, and architec236 tural organization of microvessel-like structures has 237 been a particular focus. For example, his group has 238 pioneered studies which show that cellular crosstalk xiv About the Editors 239 between osteoblasts or fibroblasts and endothelial cells 240 direct microvessel formation on open porous 3D scaf241 folds of all material classes (metals, ceramics, and poly242 mers). Kirkpatrick’s research activity has been 243 supported over many years by the German Research 244 Foundation (DFG), the Federal Ministry of Education 245 & Research (BMBF), The German-Israeli Foundation 246 247 (GIF), and the European Commission (EC).

Heinz Redl Ludwig Boltzmann Institute for Clinical 250 and Experimental Traumatology. 251 Heinz Redl has a background in biochemistry, with 252 almost 40 years’ experience in trauma and regenerative 253 medicine research. He was the director of the Ludwig 254 Boltzmann Institute of Experimental and Clinical 255 Traumatology within the main trauma research center 256 of AUVA (1998–2019), representing seven trauma and 257 four rehabilitation centers, and holds the position of 258 associate professor at the Technical University Vienna, 259 Institute for Chemical Engineering, plus adjunct profes260 sor at the University of Texas Medical Branch at Gal261 veston and at the Medical University of Vienna. He 262 recently started a new project “Senescence and Healing 263 of Wounds.” Prof. Redl coordinates the Austrian Cluster 264 for Tissue Regeneration since 2006, which includes 265 28 work groups from academia with multiple research 266 targets and 12 spin-off groups. To further enhance 267 industry cooperation, he founded in 1998 the company 268 Trauma Care Consult, which is specialized on preclini269 cal research and assists products registration at FDA and 270 EMA. In 2014, he co-founded the spin-off company 271 Liporegena and in 2017 MorphoMed. Prof. Redl orga272 nized many conferences in the field of regenerative 273 medicine such as the World Congress for Tissue Engi274 neering and Regenerative Medicine (TERMIS 2012) 275 and many annual workshops (Winterschool Radstadt 2^40 years) and developer of surgical devices 285 in current clinical use and has many collaboration pro286 jects with major industry partners.

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  • Dieser Titel kann aktuell nicht über den Webshop vorbestellt werden. Bitte wenden Sie sich an unseren Kundenservice per E-Mail (Customerservice@springernature.com) oder per Telefon (+49 6221 3450), um den Titel vorzubestellen.
  • Erscheinungstermin: 13. Juni 2021
  • ISBN 978-3-319-54585-1
  • Kostenfreier Versand für Individualkunden weltweit
  • Institutionelle Kunden wenden sich bitte an ihren Kundenbetreuer
  • Bitte beachten Sie, dass folgende Coronavirus Versandbeschränkungen bestehen
eReference 427,99 €
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Bibliografische Information

Bibliographic Information
Buchtitel
Vascularization for Tissue Engineering and Regenerative Medicine
Herausgeber
  • Wolfgang Holnthoner
  • Andrea Banfi
  • James Kirkpatrick
  • Heinz Redl
Titel der Buchreihe
Tissue Engineering and Regeneration
Copyright
2021
Verlag
Springer International Publishing
Copyright Inhaber
Springer Nature Switzerland AG
Druckausgabe + eBook ISBN
978-3-319-54585-1
eReference ISBN
978-3-319-54586-8
Druckausgabe ISBN
978-3-319-54584-4
Buchreihen ISSN
2731-0558
Auflage
1
Seitenzahl
XXI, 555
Anzahl der Bilder
6 schwarz-weiß Abbildungen, 86 Abbildungen in Farbe
Themen