Nanoscale Insights into Ion-Beam Cancer Therapy

1. Front Matter

   Pages i-xx

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2. Multiscale Physics of Ion-Beam Cancer Therapy

   • Eugene Surdutovich, Andrey V. Solov’yov

   Pages 1-60

3. Propagation of Swift Protons in Liquid Water and Generation of Secondary Electrons in Biomaterials

   • Pablo de Vera, Rafael Garcia-Molina, Isabel Abril

   Pages 61-98

4. Monte Carlo-Based Modeling of Secondary Particle Tracks Generated by Intermediate- and Low-Energy Protons in Water

   • Alexey Verkhovtsev, Pedro Arce, Antonio Muñoz, Francisco Blanco, Gustavo García

   Pages 99-119

5. Ion Collisions with Biomolecules and Biomolecular Clusters

   • Patrick Rousseau, Bernd A. Huber

   Pages 121-157

6. Dissociative Electron Attachment to Biomolecules

   • Ilko Bald, Roman Čurík, Janina Kopyra, Michal Tarana

   Pages 159-207

7. Photoprocesses with Biomolecules in the Gas Phase

   • Paola Bolognesi, Lorenzo Avaldi

   Pages 209-235

8. Irradiation-Induced Processes with Atomic Clusters and Nanoparticles

   • Alexey Verkhovtsev, Andrei V. Korol, Andrey V. Solov’yov

   Pages 237-276

9. On the Quantum Description of Irradiation Dynamics in Systems of Biological Relevance

   • P. M. Dinh, L. Bouëssel du Bourg, C.-Z. Gao, Bin Gu, L. Lacombe, M. McAllister et al.

   Pages 277-309

10. Multiscale Modelling of Molecular Processes for Biomedical and Nanotechnology Applications with MBN Explorer

    • Andrey V. Solov’yov

    Pages 311-337

11. Thermo-Mechanical Damage of Biomolecules Under Ion-Beam Radiation

    • Pablo de Vera, Nigel J. Mason, Eugene Surdutovich, Andrey V. Solov’yov

    Pages 339-357

12. Predictive Assessment of Biological Damage Due to Ion Beams

    • Alexey Verkhovtsev, Eugene Surdutovich, Andrey V. Solov’yov

    Pages 359-377

13. New Research in Ionizing Radiation and Nanoparticles: The ARGENT Project

    • M. Bolsa Ferruz, V. Ivošev, K. Haume, L. Ellis-Gibbings, A. Traore, V. Thakare et al.

    Pages 379-434

14. Biophysics Modeling to Optimize Ion Beam Cancer Therapy

    • Michaël Beuve

    Pages 435-465

15. Treatment Planning Systems and Hadron Therapy Practice in France

    • Ludovic De Marzi, Annalisa Patriarca, Alejandro Mazal, Jean-Louis Habrand

    Pages 467-494

16. Back Matter

    Pages 495-498

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This book provides a unique and comprehensive overview of state-of-the-art understanding of the molecular and nano-scale processes that play significant roles in ion-beam cancer therapy. It covers experimental design and methodology, and reviews the theoretical understanding of the processes involved. It offers the reader an opportunity to learn from a coherent approach about the physics, chemistry and biology relevant to ion-beam cancer therapy, a growing field of important medical application worldwide.

The book describes phenomena occurring on different time and energy scales relevant to the radiation damage of biological targets and ion-beam cancer therapy from the molecular (nano) scale up to the macroscopic level. It illustrates how ion-beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal tissue whilst maximizing cell-killing within the tumour, offering a significant development incancer therapy. The full potential of such therapy can only be realized by better understanding the physical, chemical and biological mechanisms, on a range of time and space scales that lead to cell death under ion irradiation. This book describes how, using a multiscale approach, experimental and theoretical expertise available can lead to greater insight at the nanoscopic and molecular level into radiation damage of biological targets induced by ion impact.

The book is intended for advanced students and specialists in the areas of physics, chemistry, biology and medicine related to ion-beam therapy, radiation protection, biophysics, radiation nanophysics and chemistry, atomic and molecular physics, condensed matter physics, and the physics of interaction of charged particles with matter. One of the most important features of the book is the inclusive multiscale approach to the understanding of complex and highly interdisciplinary processes behind ion-beam cancer therapy, which stretches from the atomistic level up to the biological scale and is demonstrated to be in excellent agreement with experimental observations.

• COST Action Nano-IBCT
• Collisions and DNA double strand breaks
• Dissociative electron attachment process
• Heavy ion therapy
• Ion-beam cancer therapy
• Irradiation of biological targets with ions
• Multiscale approach to ion-beam cancer therapy
• Proton-beam cancer therapy
• Radiation damage in biological systems
• Radiation dosimetry
• Radiation nanochemistry
• Radiobiological effects with nanoparticles

• Frankfurter Innovationszentrum Biotechnologie, MBN Research Center , Frankfurt, Germany

  Andrey V. Solov’yov

Professor Andrey Solov'yov is Editor-in-Chief of EPJD Atomic, Molecular, Optical and Plasma Physics from January 2015. He is Scientific and Executive Director of the MBN Research Center, Frankfurt am Main, Professor at the Peter the Great Saint-Petersburg Polytechnic University and the Leading Research Fellow at the A.F. Ioffe Physical-Technical Institute, Russian Academy of Sciences, Correspondent Member of European Academy of Sciences, Arts and Literature, Coordinator of several large European Projects in the interdisciplinary fields of Physics, Chemistry, Biology and Material Science, author / co-author of large number of research articles in high impact journals and books.

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