Introduction to Molecular Vaccinology

1. Front Matter

   Pages i-xix

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2. Vaccine Science

   1. Front Matter

      Pages 1-1

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   2. From Pasteur to Personalized Vaccines

      • Matthias Giese

      Pages 3-24

   3. Basic Vaccine Immunology

      • Matthias Giese

      Pages 25-61

   4. Mucosal Immunity

      • Matthias Giese

      Pages 63-95

   5. Pediatric Immunology

      • Matthias Giese

      Pages 97-110

   6. Elderly Immunology

      • Matthias Giese

      Pages 111-121

3. Vaccine Design

   1. Front Matter

      Pages 123-123

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   2. Antigens and Epitopes

      • Matthias Giese

      Pages 125-143

   3. Adjuvants

      • Matthias Giese

      Pages 145-163

   4. Micro- and Nanotechnology

      • Matthias Giese

      Pages 165-198

   5. Types of Recombinant Vaccines

      • Matthias Giese

      Pages 199-232

   6. Delivery Technologies

      • Matthias Giese

      Pages 233-258

   7. Formulation and Manufacturing

      • Matthias Giese

      Pages 259-291

4. Therapeutical Vaccines

   1. Front Matter

      Pages 293-293

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   2. Cancer Vaccines

      • Matthias Giese

      Pages 295-333

   3. Noninfectious Noncancer (NINC) Vaccines

      • Matthias Giese

      Pages 335-364

5. Back Matter

   Pages 365-373

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This textbook provides an easy-to-understand introduction to the complex topic of vaccine research and development. It gives a comprehensive though clearly arranged insight to the most important aspects of molecular vaccinology, leading from the basics in immunology, to design of vaccines and mode of action of vaccines to the actual formulation, manufacturing and registration of vaccines. The volume is therefore a valuable text about modern vaccinology for graduate students and a basic introduction for newcomers in vaccine design and development.

• Molecular Biology
• Molecular Vaccines
• Immunology
• Vaccine Design
• Prophylaxis and Therapy
• vaccines

• Institute for Molecular Vaccines, Heidelberg, Germany

  Matthias Giese

Matthias Giese has studied Molecular Biology and Biochemistry at the Saarland University/Germany.  He got a first PhD in Immunology in the German Cancer Research Center/ Heidelberg. In 1994, after Matthias Giese has joined the pharmaceutical industry some years ago, his team in Vienna/ Austria started the first European multicenter clinical trial with a personalized genetic engineered anti-melanoma vaccine.  Also Animal Health was interested in his expertise in modern vaccine technologies and so he changed the company and headed from now on a program on innovative vaccine approaches for the next years.  His sabbatical leave from the industry was a return back to the academic roots. At Leipzig University/ Germany Matthias Giese got a major PhD (venia legendi) in Molecular Virology. Currently he is working again for the human pharmaceutical industry and additionally he teaches graduate students as associate professor. His focus is on neoantigenes, therapeutical vaccines, and the interaction with immune checkpoint modifiers as combination therapy. Matthias Giese is author and editor of “Molecular Vaccines – From Prophylaxis to Therapy” and an enthusiastic mountain marathon runner.

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