Overview
- Presents a systematic, textbook-quality treatment of protein misfolding and its central role in neurodegeneration
- Provides a foundation for understanding the multiple causes and progression of familial and sporadic forms of neurodegenerative diseases
- Contains chapters on each of the major disease classes
- Emphasizes the pioneering experimental and computational methods that enable molecular-level explorations and the conceptual breakthroughs they produce
- Describes up-to-date theories on the mechanisms underlying amyloid and toxic-oligomer-driven synaptic impairment, neuronal failure, and death
- Includes summaries of the main points of each chapter, numerous figures, and key references
Part of the book series: Biological and Medical Physics, Biomedical Engineering (BIOMEDICAL)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (11 chapters)
Keywords
- Abeta, Tau
- Alpha-synuclein
- Alpha-synucleinopathies
- Alzheimer’s Disease
- Amyloid Fibrils
- Amyloid Oligomers
- Amyloids
- Amyotrophic Lateral Sclerosis
- Huntington’s Disease
- Intracellular Inclusions
- Neurodegeneration
- Parkinson‘s Disease
- Prions
- Protein Misfolding
- TDP-43
- TDP-43 Proteinopathies
- Tauopathies
- Unstructured Proteins
About this book
This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer’s disease and Parkinson’s disease to Huntington’s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today’s forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.
Reviews
“This text concerns protein conformational aberrations and expression in the following diseases: Alzheimer’s, Parkinson’s, Huntington’s, amyotrophic lateral sclerosis, etc. … The book is primarily for physical chemists and researchers having an interest in the molecular mechanisms of neurological diseases.” (Joseph J. Grenier, Amazon.com, March, 2016)
Authors and Affiliations
About the author
Bibliographic Information
Book Title: Fundamentals of Neurodegeneration and Protein Misfolding Disorders
Authors: Martin Beckerman
Series Title: Biological and Medical Physics, Biomedical Engineering
DOI: https://doi.org/10.1007/978-3-319-22117-5
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2015
Hardcover ISBN: 978-3-319-22116-8Published: 18 November 2015
Softcover ISBN: 978-3-319-34284-9Published: 23 August 2016
eBook ISBN: 978-3-319-22117-5Published: 06 November 2015
Series ISSN: 1618-7210
Series E-ISSN: 2197-5647
Edition Number: 1
Number of Pages: XXII, 378
Topics: Neurosciences, Biological and Medical Physics, Biophysics, Protein Science, Biomedical Engineering and Bioengineering, Neurology, Medicinal Chemistry