Preventive and Predictive Genetics: Towards Personalised Medicine

1. Front Matter

   Pages i-xx

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2. Introduction

   • Godfrey Grech, Iris Grossman

   Pages 1-6

3. Preventive and Predictive Genetics: A perspective

   • Godfrey Grech, Christian Scerri, Jeanesse Scerri, Tomris Cesuroglu

   Pages 7-41

4. Roadmap to Drug Development Enabled by Pharmacogenetics

   • James P. Bishop, Sonal B. Halburnt, Patrick A. Akkari, Scott Sundseth, Iris Grossman

   Pages 43-67

5. Pharmacogenetics—Statistical Considerations

   • Aiden Flynn, Craig Ledgerwood, Caroline O’Hare

   Pages 69-89

6. Pharmacokinetics and Pharmacogenetics: Bringing the Magic Bullet Closer to Reality

   • Janet Mifsud, Marc Maliepaard

   Pages 91-107

7. Pharmacogenetics of Adverse Drug Reactions

   • Richard Myles Turner, Munir Pirmohamed

   Pages 109-156

8. Pharmacogenomics for Haemoglobinopathies Therapeutics

   • Aikaterini Gravia, Vasiliki Chondrou, Theodora Katsila, George P. Patrinos

   Pages 157-171

9. Pharmacogenetics of Neurodegenerative Disorders

   • Ramón Cacabelos, Clara Torrellas, Pablo Cacabelos, María J. Villanueva, Sergio Piñeiro, Cristina Solveira

   Pages 173-240

10. Pharmacogenetics of Asthma

    • Anthony G. Fenech, Ian Sayers, Michael A. Portelli

    Pages 241-274

11. Pharmacogenetics and Antineoplastic Therapies

    • Jai N. Patel, Christine M. Walko, Federico Innocenti

    Pages 275-305

12. Pharmacogenetics of Coumarin Anticoagulant Therapy

    • Rianne M.F. van Schie, Talitha I. Verhoef, Anthonius de Boer, Felix J.M. van der Meer, William K. Redekop, Tom Schalekamp et al.

    Pages 307-328

13. Implementation of Genomic Medicine: Tools and Challenges

    • Godfrey Grech, Ron van Schaik, Joseph Borg

    Pages 329-347

14. Ethical Considerations in the Genomic Era

    • Bridget Ellul

    Pages 349-375

15. Back Matter

    Pages 377-378

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Pharmacogenomics supports personalized medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalized medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data.  Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions.

• Biomarkers
• Drug development
• Drug metabolism
• Personalised Medicine
• Pharmacogenetics / Pharmacogenomics
• Systems Biology
• antibacterial drug resistance

• Pathology Department, University of Malta, Msida, Malta

  Godfrey Grech

• IsraGene, Yakir, Israel

  Iris Grossman

Policies and ethics