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Springer Theses

A Novel Heme-Thiolate Peroxygenase AaeAPO and Its Implications for C-H Activation Chemistry

Autoren: Wang, Xiaoshi

Vorschau
  • Nominated as an outstanding Ph.D. thesis by Princeton University, USA
  • Represents significant scientific advance in the field of heme-thiolate enzymes
  • Provides clear and colorful illustrations with original research data
  • Give complete and detailed enzymatic function studies and mechanistic frameworks
Weitere Vorteile

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eBook 79,72 €
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  • ISBN 978-3-319-03236-8
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Hardcover 117,69 €
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  • ISBN 978-3-319-03235-1
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  • Gewöhnlich versandfertig in 3-5 Werktagen.
Softcover 99,98 €
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  • ISBN 978-3-319-35428-6
  • Kostenfreier Versand für Individualkunden weltweit
  • Gewöhnlich versandfertig in 3-5 Werktagen.
Über dieses Buch

In this thesis, Xiaoshi Wang investigates the function and mechanism of a newly discovered heme-thiolate peroxygenase, AaeAPO. This enzyme class comes from Agrocybe aegerita and is used in the conversion of inert hydrocarbons to alcohols. Xiaoshi's work focuses on an extracellular P450 enzyme which is not limited in its stability and lack of solubility and therefore is relevant for widespread industrial use. The author demonstrates that the peroxygenase catalyzes a wide range of reactions. In some cases the author even describes very difficult transformations in molecules that are highly inert. Her detailed investigations provide a mechanistic framework for how the peroxygenase catalyzes such a large number of reactions. A major highlight of this thesis is the identification of key short-lived intermediates in the catalytic cycle of the peroxygenase, using rapid kinetic and spectroscopic methods, as well as the elucidation of the thermodynamic properties of these high-energy intermediates. This work adds new insight into an important class of enzymes.

Über den Autor

Xiaoshi Wang received her B.Sc. in chemistry from Nanjing University, China in 2007. She obtained her Ph.D. in chemistry from Chemistry Department of Princeton University in August 2013. Her major research project in Prof. John T. Groves group is function and mechanistic investigation on C-H oxygenation reactions catalyzed by heme-thiolate enzymes. Subsequently, she became a post-doc fellow working with Prof. Benjamin Garcia at Perelman School of Medicine, University of Pennsylvania, focusing on studying chromatin protein PTMs during epigenetic processes.

Inhaltsverzeichnis (7 Kapitel)

Inhaltsverzeichnis (7 Kapitel)

Dieses Buch kaufen

eBook 79,72 €
Preis für Deutschland (Brutto)
  • ISBN 978-3-319-03236-8
  • Versehen mit digitalem Wasserzeichen, DRM-frei
  • Erhältliche Formate: EPUB, PDF
  • eBooks sind auf allen Endgeräten nutzbar
  • Sofortiger eBook Download nach Kauf
Hardcover 117,69 €
Preis für Deutschland (Brutto)
  • ISBN 978-3-319-03235-1
  • Kostenfreier Versand für Individualkunden weltweit
  • Gewöhnlich versandfertig in 3-5 Werktagen.
Softcover 99,98 €
Preis für Deutschland (Brutto)
  • ISBN 978-3-319-35428-6
  • Kostenfreier Versand für Individualkunden weltweit
  • Gewöhnlich versandfertig in 3-5 Werktagen.
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Bibliografische Information

Bibliographic Information
Buchtitel
A Novel Heme-Thiolate Peroxygenase AaeAPO and Its Implications for C-H Activation Chemistry
Autoren
Titel der Buchreihe
Springer Theses
Copyright
2016
Verlag
Springer International Publishing
Copyright Inhaber
Springer International Publishing Switzerland
eBook ISBN
978-3-319-03236-8
DOI
10.1007/978-3-319-03236-8
Hardcover ISBN
978-3-319-03235-1
Softcover ISBN
978-3-319-35428-6
Buchreihen ISSN
2190-5053
Auflage
1
Seitenzahl
XXXII, 130
Themen