Skip to main content
SpringerLink
Log in

Tumor Suppressor Par-4

Role in Cancer and Other Diseases

  • Book
  • © 2021

Overview

Editors:
  1. Vivek M. Rangnekar

    1. Assoc Dir, Markey Cancer Center, Univ of Kentucky, Lexington, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides researchers and clinicians with new insights into potential drug discovery and development for various cancers and other human diseases

  • Describes the role of Par-4 in diverse diseases and their treatment

  • Highlights novel facets of Par-4 and its role in future clinical trials

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (22 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Role of Par-4 in EMT

    • Mir Mohd Faheem, Archana Katoch, Anindya Goswami
    Pages 1-23

  3. Prostate Apoptosis Response-4 in Inflammation

    • Nadia El-Guendy
    Pages 25-40

  4. Par-4 in Chemoresistant Ovarian and Endometrial Cancers

    • François Fabi, Pascal Adam, Eric Asselin
    Pages 41-58

  5. Regulation and Role of Par-4 in Gastrointestinal Tumors

    • Rosalyn B. Irby, Christina Leah B. Kline, Arun K. Sharma
    Pages 59-68

  6. Role of Par-4 in Radiation Sensitivity of Cancer

    • Seema Gupta, Amogh Narendra, Satvik Lolla, Muskan Qureshi, Muhammad Hamza Qureshi, Mansoor M. Ahmed
    Pages 69-76

  7. Prostate Apoptosis Response-4: a Therapeutic Target for Malignant Gliomas

    • Jeevan Ghosalkar, Vinay Sonawane, Mohsina Khan, Kalpana Joshi, Padma Shastry
    Pages 77-111

  8. Involvement of Par-4 in Breast Cancer

    • Simone Aparecida de Bessa-Garcia, Maria Aparecida Nagai
    Pages 113-131

  9. Role of Par-4 in B-Cell Hematological Malignancies

    • Sunil K. Noothi, Mary K. McKenna, Sara S. Alhakeem, James P. Collard, J. T. Greene, Natarajan Muthusamy et al.
    Pages 133-148

  10. The Par-4 Tumor Suppressor Protein in TCL1-Induced Leukemogenesis

    • Joseph T. Greene, Mary K. McKenna, Subbarao Bondada, Natarajan Muthusamy
    Pages 149-159

  11. Potential of PAR-4 as a Therapeutic Target for Pancreatic Cancer

    • Md. Hafiz Uddin, Asfar S. Azmi, Ramzi M. Mohammad
    Pages 161-170

  12. Developing Quinoline-based Secretagogues for Prostate Apoptosis Response-4 Protein (Par-4) as Potential Antineoplastic Agents

    • Vitaliy M. Sviripa, Ravshan Burikhanov, Chunming Liu, David S. Watt
    Pages 171-189

  13. Recombinant Production and Characterization of Par-4/SAC

    • Fang Zheng, Chang-Guo Zhan
    Pages 191-201

  14. Role of PAR-4 in Ceramide-Inducible Effects in Neurodegeneration

    • Ahmed Elsherbini, Erhard Bieberich
    Pages 203-214

  15. Par-4 in Neuronal Death and Survival in Alzheimer’s Disease and Other Neurogenerative Diseases

    • Qing Guo, Jun Xie, Chelsea J. Guo
    Pages 215-245

  16. Par-4-Dependent Apoptosis of Pancreatic Islet β Cells in Type 2 Diabetes

    • Qi Nan Wu, Ling Zhang, Bing Chen
    Pages 247-253

  17. Role of PRKC Apoptosis WT1 Regulator in Ocular Development and Diseases

    • Tahseen Ahmed, Tuneer Ranjan Mallick, Michael A. Walter, Moulinath Acharya
    Pages 255-267

  18. Par-4 in Apoptosis during Human Salivary Gland Development and Tumorigenesis

    • Cláudia Malheiros Coutinho-Camillo, Ágatha Nagli de Mello Gomes, Fernanda de Paula, Maria Aparecida Nagai, Silvia Vanessa Lourenço
    Pages 269-279

  19. Roles for Par-4 in Kidney Pathophysiology

    • Lu Ren, Shaolin Shi
    Pages 281-288

  20. Lessons from Mouse Models

    • Nathalia Araujo, Nikhil Hebbar, Vivek M. Rangnekar
    Pages 289-301
Back to top

Keywords

About this book

Par-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. On the other hand, endogenous Par-4 sensitizes cells to the action of a broad range of apoptotic inducers acting via the extrinsic and intrinsic pathways. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in cancer and other diseases, such as Alzheimer’s and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials.


This second, companion volume will provide a comprehensive overview of Par-4’s role in cancer and other diseases. Chapters are written by leading researchers, and will be useful for a broad audience across the scientific community, particularly students and trainees, who are the next generation of scientists and clinicians to participate in new studies and discoveries on Par-4.

Editors and Affiliations

  • Assoc Dir, Markey Cancer Center, Univ of Kentucky, Lexington, USA

    Vivek M. Rangnekar

About the editor

​Vivek M. Rangnekar, Ph.D. is Professor and Alfred Cohen Chair in Oncology Research in the Department of Radiation Medicine and Associate Director of the Markey Cancer Center at the University of Kentucky. His laboratory studies the molecular cross-talk between oncogenes and tumor suppressor genes in an effort to tilt the balance in favor of tumor suppressor function. Dr. Rangnekar originally identified and discovered the tumor suppressor protein Par-4/PAWR in 1993.

Bibliographic Information

  • Book Title: Tumor Suppressor Par-4

  • Book Subtitle: Role in Cancer and Other Diseases

  • Editors: Vivek M. Rangnekar

  • DOI: https://doi.org/10.1007/978-3-030-80558-6

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-80557-9Published: 21 December 2021

  • eBook ISBN: 978-3-030-80558-6Published: 01 January 2022

  • Edition Number: 1

  • Number of Pages: X, 331

  • Number of Illustrations: 28 b/w illustrations, 93 illustrations in colour

  • Topics: Cancer Research, Oncology

Publish with us

Policies and ethics

Back to top

Search

Navigation