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  • Textbook
  • © 2021

Cancer Biology: How Science Works

  • Includes a large figure to text ratio

  • Based of 15 years teaching experience on the topic

  • Provides in a condensed form an overview on the present understanding of cancer biology

  • Combines basic biology with clinical examples and hands-on care

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xvii
  2. Introduction to Cancer

    • Carsten Carlberg, Eunike Velleuer
    Pages 1-16
  3. Oncogenes and Signal Transduction

    • Carsten Carlberg, Eunike Velleuer
    Pages 17-28
  4. Tumor Suppressor Genes and Cell Fate Control

    • Carsten Carlberg, Eunike Velleuer
    Pages 29-40
  5. Multi-step Tumorigenesis and Genome Instability

    • Carsten Carlberg, Eunike Velleuer
    Pages 41-53
  6. Cancer Genomics

    • Carsten Carlberg, Eunike Velleuer
    Pages 55-66
  7. Cancer Epigenomics

    • Carsten Carlberg, Eunike Velleuer
    Pages 67-85
  8. Aging and Cancer

    • Carsten Carlberg, Eunike Velleuer
    Pages 87-99
  9. Tumor Microenvironment

    • Carsten Carlberg, Eunike Velleuer
    Pages 101-114
  10. Metastasis and Cachexia

    • Carsten Carlberg, Eunike Velleuer
    Pages 115-128
  11. Cancer Immunity

    • Carsten Carlberg, Eunike Velleuer
    Pages 129-146
  12. Architecture of Cancer Therapies

    • Carsten Carlberg, Eunike Velleuer
    Pages 147-161
  13. Back Matter

    Pages 163-167

About this book

Cancer is a collection of diseases that can affect basically every organ of our body, all of which have in common uncontrolled cellular growth. The cells forming our body have the potential to grow in the context of wound healing or for the constant replacement of cells in our blood, skin or intestine. Behind every newly diagnosed malignant tumor in adulthood there is an individual history of probably 20 or more years of tumorigenesis. Therefore, malignant tumor formation often takes time making cancer in most cases to an aging-related disease that we seem not to be able to evade. However, tumorigenesis is dependent on multiple environmental influences, many of which we have under control by lifestyle decisions, such as retaining from smoking, selecting healthy food and being physically active. Thus, cancer preventive interventions are the most effective way to fight against cancer. 

This textbook wants not only to describe basic mechanisms leading to cancer but also to provide the readers with a more holistic view including cancer surveaillance mechanisms of the immune system. We will place these insights in the context of the personal consequences of everyone’s lifestyle decisions. The content of the book is linked to the lecture course in “Cancer Biology”, which is given by Prof. Carlberg since 2005 at the University of Eastern Finland in Kuopio. Moreover, biological processes explained in this book will be set into a clinical context using the experience of Dr. Velleuer in the daily care in oncology. This book also relates to the textbooks “Mechanisms of Gene Regulation: How Science Works” (ISBN 978-3-030-52321-3), “Human Epigenetics: How Science Works” (ISBN 978-3-030-22907-8) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4), the studying of which may be interesting to readers who like to get more detailed information.

Authors and Affiliations

  • Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland

    Carsten Carlberg

  • Department for Pediatric Hemato-Oncology, Children’s Hospital, Krefeld, Germany

    Eunike Velleuer

About the authors

Carsten Carlberg graduated 1989 with a PhD in biochemistry at the Free University Berlin (Germany). After positions as postdoc at Roche (Basel, Switzerland), group leader at the University of Geneva (Switzerland) and docent at the University of DĂĽsseldorf (Germany) he is since 2000 full professor of biochemistry at the University of Eastern Finland in Kuopio (Finland). His work focuses on mechanisms of gene regulation by nuclear hormones, in particular on vitamin D. At present Prof. Carlberg focuses projects on epigenome-wide effects of vitamin D on the human immune system in the context of cancer.
 
Eunike Velleuer graduated 2006 as MD at the University of Düsseldorf (Germany) and specialized in 2016 in pediatric hemato-oncology. At present, she serves as senior physician at the Children’s Hospital Neuwerk in Mönchengladbach (Germany) as well as a research associate at the University of Düsseldorf. Her special clinical focus is the cancer predisposition syndrome Fanconi anemia. Herein, her research interest is early detection and prevention of oral squamous cell carcinoma and identifying patients with Fanconi anemia at risk. Furthermore, she is interested in increasing patient’s resilience and find alternative ways for long-lasting empowerment.
 



Bibliographic Information

  • Book Title: Cancer Biology: How Science Works

  • Authors: Carsten Carlberg, Eunike Velleuer

  • DOI: https://doi.org/10.1007/978-3-030-75699-4

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021

  • Softcover ISBN: 978-3-030-75698-7Published: 06 July 2021

  • eBook ISBN: 978-3-030-75699-4Published: 05 July 2021

  • Edition Number: 1

  • Number of Pages: XVII, 167

  • Number of Illustrations: 1 b/w illustrations, 71 illustrations in colour

  • Topics: Cancer Research, Genetics and Genomics, Biochemistry, general

Buy it now

Buying options

eBook USD 54.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access