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Epigenetics and Proteomics of Leukemia

A Synergy of Experimental Biology and Computational Informatics

  • Compiles the latest research on the study of epigenetics and proteomics of leukemia

  • Introduces computational methods to evaluate and analyze changes in proteome and chromatin remodeling

  • Demonstrates synergy of biological methods with computational informatics for leukemia research

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-lix
  2. Epigenetics in Leukemia

    1. Front Matter

      Pages 1-1
    2. Epigenetic and Genetic Alterations in Leukemia

      • Rūta Navakauskienė, Dalius Navakauskas, Veronika Borutinskaitė, Dalius Matuzevičius
      Pages 3-23
    3. Epigenetic Modifiers and Their Inhibitors in Leukemia Treatment

      • Rūta Navakauskienė, Dalius Navakauskas, Veronika Borutinskaitė, Dalius Matuzevičius
      Pages 25-66
    4. Chromatin Remodeling During Leukemia Cell Proliferation and Differentiation

      • Rūta Navakauskienė, Dalius Navakauskas, Veronika Borutinskaitė, Dalius Matuzevičius
      Pages 67-122
  3. Proteomics in Leukemia

    1. Front Matter

      Pages 123-123
    2. Proteome in Leukemic vs. Differentiated Leukemia Cells

      • Rūta Navakauskienė, Dalius Navakauskas, Veronika Borutinskaitė, Dalius Matuzevičius
      Pages 125-163
    3. Protein Phosphorylation in Leukemia

      • Rūta Navakauskienė, Dalius Navakauskas, Veronika Borutinskaitė, Dalius Matuzevičius
      Pages 165-194
    4. Computational Methods for Proteome Analysis

      • Rūta Navakauskienė, Dalius Navakauskas, Veronika Borutinskaitė, Dalius Matuzevičius
      Pages 195-282
  4. Protein Localization in Leukemia

    1. Front Matter

      Pages 283-283
    2. Protein Translocation into the Nucleus during Leukemia Cell Differentiation

      • Rūta Navakauskienė, Dalius Navakauskas, Veronika Borutinskaitė, Dalius Matuzevičius
      Pages 285-297
    3. Protein Visualization in Leukemia Cells

      • Rūta Navakauskienė, Dalius Navakauskas, Veronika Borutinskaitė, Dalius Matuzevičius
      Pages 299-314
    4. Computational Methods for Protein Localization Analysis

      • Rūta Navakauskienė, Dalius Navakauskas, Veronika Borutinskaitė, Dalius Matuzevičius
      Pages 315-344
  5. Back Matter

    Pages 345-406

About this book

This book reviews the current state of epigenetics and proteomics of leukemia and introduces the methods that are important to process and evaluate these factors in leukemia. In particular, epigenetic modifiers and their inhibitors in leukemia treatment as well as approaches to the epigenetic treatment of leukemia are covered. Various computational methods for proteome analysis are also described in detail, including 2DE fractionation and visualization, proteomic data processing, image acquisition and data anlaysis, and more. Protein localization in leukemia is also covered, in addition to the future of leukemia therapy.

Epigenetics and Proteomics of Leukemia is an ideal book for advanced biomedical scientists and students, medical doctors and students, bioinformatics and health informatics researchers, computational biologists, structural biologists, systems biologists, and bioengineers.

Authors and Affiliations

  • Department of Molecular Cell Biology Institute of Biochemistry Life Sciences Center, Vilnius University, Vilnius, Lithuania

    R¯uta Navakauskien˙e, Veronika Borutinskait˙e

  • Department of Electronic Systems Faculty of Electronics, Vilnius Gediminas Technical University, Vilnius, Lithuania

    Dalius Navakauskas, Dalius Matuzevi˘cius

About the authors

Rūta NAVAKAUSKIENĖ, Dr. Prof.
Department of Molecular Cell Biology, Institute of Biochemistry, Life Sciences Center, Vilnius University, Sauletekio av. 7, LT-10257 Vilnius, Lithuania


Dalius NAVAKAUSKAS, Dr. Prof.
Department of Electronic Systems, Faculty of Electronics, Vilnius Gediminas Technical University, Naugarduko st. 41-426, LT-03227 Vilnius, Lithuania


Veronika BORUTINSKAITĖ, Dr.
Department of Molecular Cell Biology, Institute of Biochemistry, Life Sciences Center, Vilnius University, Sauletekio av. 7, LT-10257 Vilnius, Lithuania


Dalius MATUZEVIČIUS, Dr. Assoc. Prof.
Department of Electronic Systems, Faculty of Electronics, Vilnius Gediminas Technical University, Naugarduko st. 41-413, LT-03227 Vilnius, Lithuania

Bibliographic Information

Buy it now

Buying options

eBook USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 189.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access