Drug-Induced Oral Complications

1. Front Matter

   Pages i-vii

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2. Adverse Drug Reactions, Iatrogenic Diseases, Drug Safety, and Pharmacovigilance: Importance and Interest for Patients and Their Physicians

   • Jean-Louis Montastruc, Haleh Bagheri, Genevieve Durrieu, Isabelle Lacroix, François Montastruc

   Pages 1-6

3. Drug-Induced Gingival Overgrowth

   • Léa Bontemps, Frédérick Gaultier, Fani Anagnostou, Anne-laure Ejeil, Sophie-Myriam Dridi

   Pages 7-24

4. Drug-Induced Oral Mucosal Pigmentation

   • Henri Tenenbaum, Catherine Petit, Olivier Huck

   Pages 25-33

5. Drug-Induced Oral Ulcers

   • Sara Laurencin-Dalicieux, Sarah Cousty

   Pages 35-41

6. Drug-Induced Oral Lichenoid Reaction

   • Jean-Christophe Fricain

   Pages 43-50

7. Medication-Related Osteonecrosis of the Jaws

   • Leonor Costa Mendes, Bruno Courtois

   Pages 51-59

8. Drug-Induced Oral Bleeding

   • Cedric Mauprivez, Sébastien Laurence

   Pages 61-73

9. Drug-Induced Taste Disorders

   • Vianney Descroix

   Pages 75-79

10. Drug-Induced Salivary Gland Disturbances

    • Sara Laurencin-Dalicieux, Bruno Souche, Sarah Cousty

    Pages 81-89

11. Drug-Induced Oral Infections

    • Sylvie Boisramé, Anne-Gaëlle Chaux-Bodard

    Pages 91-100

12. Drug-Induced Facial Diseases

    • Marie Masson, Carle Paul

    Pages 101-119

13. Conclusion: Drug-Induced Oral Complications

    • Sarah Cousty, Sara Laurencin-Dalicieux

    Pages 121-122

14. Back Matter

    Pages 123-125

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This book provides detailed information on the prevalence and manifestations of the most important oral complications associated with different drug treatments, focusing especially on recently developed therapies. Among the diverse adverse drug reactions covered are gingival overgrowth, ulcerations, lichenoid reactions, pigmentation, and bullous reactions. The potential direct toxic effects on bone of drugs that prevent bone mass loss, such as bisphosphonates and denosumab, are fully examined, as is the occurrence of spontaneous oral bleeding in patients receiving antithrombotic therapies. Further chapters focus on drug-induced taste disorders and salivary gland disturbances, including xerostomia, swelling, and hypersalivation. The enhanced risk of oral infections when using chemotherapy and biotherapy is addressed, and the closing chapter examines drug-related perioral and facial complications. This book is a collaborative work that brings together clinicians, surgeons, and specialists in drug safety surveillance. It will be of value for all dental and medical practitioners who encounter these complications in their clinical practice.

• Drug-induced gingival overgrowth
• Oral manifestations of drug allergy
• Drug-induced osseous complications
• Drug-induced oral infections
• Bisphosphonates and denosumab
• Drug-induced oral bleeding

• Oral Surgery Oral Medecine Department, Dental Faculty, Paul Sabatier University, Toulouse, France

  Sarah Cousty

• Periodontology Department, Dental Faculty, Paul Sabatier University, Toulouse, France

  Sara Laurencin-Dalicieux

Sarah Cousty, DDS, PhD, works at the Dental Faculty and the Centre Hospitalier Universitaire de Toulouse (University Hospital), France, where she is a Professor and Senior Lecturer and Hospital Practitioner in Oral Surgery. In 2002, Dr. Cousty gained a Masters Degree in Biological and Medical Sciences and a Degree in Epidemiology (applied to dental research) at Paul Sabatier University in Toulouse. She went on to obtain her DDS at the same university in 2004 (First Class Honors, silver medalist) and completed a PhD in Electrical Engineering, Electrotechnical studies and Telecommunications in 2007. She took up her present position in 2008.

Sara Laurencin-Dalicieux, DDS, PhD, works at the Dental Faculty and the Centre Hospitalier Universitaire de Toulouse (University Hospital), France, where she is a Senior Lecturer and Hospital Practitioner in Periodontology. In 2003, Dr. Laurencin-Dalicieux completed a Masters Degree in Biological and Medical Sciences and her DDS(First Class Honors, bronze medalist) at Paul Sabatier University in Toulouse. She gained a PhD in Biology, Health and Biotechnologies and a Degree in Periodontology from the same university in 2010 and 2011, respectively. She took up her current position in 2013.

Both authors are in currently charge of the multidisciplinary oral mucosa consultation in Toulouse's University Hospital which interracts and finds itself at the crossroad of other medical specialties such as Dermatology, Maxillo-facial Surgery, ENT and Internal Medicine.

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