Overview
- Illustrates the structure, isolation, composition, and the functional reconstitution of the porosomes nanomachine: cells’ secretory portal
- Describes diseases targeting proteasomes, as well as diseases resulting from altered chaperonin, porosome, and ATP synthase
- Provides readers with an overview of the possible mechanisms involved in the assembly of cellular nanomachines
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Table of contents (8 chapters)
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Front Matter
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Back Matter
Keywords
About this book
In this book, the major paradigm-shifting discoveries made in the past century on key cellular nanomachines are described in great detail: their complex yet precise and elegant design and function, as well as the diseases linked to their dysfunction and the therapeutic approaches to overcome them. The major focus of this book is the “porosome” nanomachine, the universal secretory portal in cells. This is an ideal book for students, researchers, and professionals in the fields of nanoscience and nanotechnology.
Authors and Affiliations
About the author
Bhanu P. Jena is George E. Palade University Professor & Distinguished Professor of Physiology at Wayne State University School of Medicine, and Director of the NanoBioScience Institute. In 1996 while an Assistant Professor at Yale University School of Medicine, he discovered the ‘porosome’, a new cellular nanomachine that serves as the secretory portal in cells. Prof. Jena is the recipient of numerous awards and honours, among them six honorary doctorates, the Aaron Klug Award, Palade Gold Medal, and AAAS Fellow. He received his Ph.D. from Iowa State University followed by postdoctoral training as a Swebilius Fellow at Yale University.
Bibliographic Information
Book Title: Cellular Nanomachines
Book Subtitle: From Discovery to Structure-Function and Therapeutic Applications
Authors: Bhanu P. Jena
DOI: https://doi.org/10.1007/978-3-030-44496-9
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2020
Hardcover ISBN: 978-3-030-44495-2Published: 30 April 2020
Softcover ISBN: 978-3-030-44498-3Published: 30 April 2021
eBook ISBN: 978-3-030-44496-9Published: 29 April 2020
Edition Number: 1
Number of Pages: XVIII, 109
Number of Illustrations: 1 b/w illustrations, 40 illustrations in colour
Topics: Cell Biology, Protein Science, Biological Microscopy, Animal Biochemistry, Biological and Medical Physics, Biophysics